Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules

Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules

The dTAG system is used to rapidly deplete tagged target proteins in vitro and in vivo, but there are context- and protein-specific differences in its effectiveness. Here, the authors develop a second generation dTAG molecule that can degrade previously recalcitrant target proteins in cells and mice...

Full description

Saved in:
Bibliographic Details
Main Authors: Behnam Nabet, Fleur M. Ferguson, Bo Kyung A. Seong, Miljan Kuljanin, Alan L. Leggett, Mikaela L. Mohardt, Amanda Robichaud, Amy S. Conway, Dennis L. Buckley, Joseph D. Mancias, James E. Bradner, Kimberly Stegmaier, Nathanael S. Gray
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Science
Q
Online Access:https://doaj.org/article/459b2972ed404c94bc46191739350a3c
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/459b2972ed404c94bc46191739350a3c

Similar Items