Crystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal fHbp

Factor H binding protein (fHbp) is a meningococcal virulence factor and a component of vaccines against serogroup B Neisseria meningitidis. Here, the authors characterize the vaccine-elicited human antibody Fab 1A12 and present both the free and the fHbp-bound Fab 1A12 crystal structures.

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Autores principales:	Jacinto López-Sagaseta, Peter T. Beernink, Federica Bianchi, Laura Santini, Elisabetta Frigimelica, Alexander H. Lucas, Mariagrazia Pizza, Matthew J. Bottomley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/45a02285ed024573983982388854fecb
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spelling	oai:doaj.org-article:45a02285ed024573983982388854fecb2021-12-02T15:33:55ZCrystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal fHbp10.1038/s41467-018-02827-72041-1723https://doaj.org/article/45a02285ed024573983982388854fecb2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02827-7https://doaj.org/toc/2041-1723Factor H binding protein (fHbp) is a meningococcal virulence factor and a component of vaccines against serogroup B Neisseria meningitidis. Here, the authors characterize the vaccine-elicited human antibody Fab 1A12 and present both the free and the fHbp-bound Fab 1A12 crystal structures.Jacinto López-SagasetaPeter T. BeerninkFederica BianchiLaura SantiniElisabetta FrigimelicaAlexander H. LucasMariagrazia PizzaMatthew J. BottomleyNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jacinto López-Sagaseta Peter T. Beernink Federica Bianchi Laura Santini Elisabetta Frigimelica Alexander H. Lucas Mariagrazia Pizza Matthew J. Bottomley Crystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal fHbp
description	Factor H binding protein (fHbp) is a meningococcal virulence factor and a component of vaccines against serogroup B Neisseria meningitidis. Here, the authors characterize the vaccine-elicited human antibody Fab 1A12 and present both the free and the fHbp-bound Fab 1A12 crystal structures.
format	article
author	Jacinto López-Sagaseta Peter T. Beernink Federica Bianchi Laura Santini Elisabetta Frigimelica Alexander H. Lucas Mariagrazia Pizza Matthew J. Bottomley
author_facet	Jacinto López-Sagaseta Peter T. Beernink Federica Bianchi Laura Santini Elisabetta Frigimelica Alexander H. Lucas Mariagrazia Pizza Matthew J. Bottomley
author_sort	Jacinto López-Sagaseta
title	Crystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal fHbp
title_short	Crystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal fHbp
title_full	Crystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal fHbp
title_fullStr	Crystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal fHbp
title_full_unstemmed	Crystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal fHbp
title_sort	crystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal fhbp
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/45a02285ed024573983982388854fecb
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Crystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal fHbp

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