Pathophysiology of Depression and Novel Sources of Phytochemicals for its Treatment – A Systematic Review

The rising burden of depression, which will soon be the second most common cause of disability in the world, is requesting new ways to treat and prevent it. Due to high number of significant adverse drug reactions of the conventional treatment, the modern pharmaceutical industry is more often turnin...

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Autores principales:	Bakalov D., Hadjiolova R., Pechlivanova D.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2020
Materias:	depression mesembrine type alkaloids narcissus phytomedicine Medicine R
Acceso en línea:	https://doaj.org/article/45a66de35d274fdea88e0031d77e8676
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spelling	oai:doaj.org-article:45a66de35d274fdea88e0031d77e86762021-12-02T17:48:36ZPathophysiology of Depression and Novel Sources of Phytochemicals for its Treatment – A Systematic Review0324-175010.2478/amb-2020-0049https://doaj.org/article/45a66de35d274fdea88e0031d77e86762020-11-01T00:00:00Zhttps://doi.org/10.2478/amb-2020-0049https://doaj.org/toc/0324-1750The rising burden of depression, which will soon be the second most common cause of disability in the world, is requesting new ways to treat and prevent it. Due to high number of significant adverse drug reactions of the conventional treatment, the modern pharmaceutical industry is more often turning their focus to novel plant-based solutions. We performed literature research based on standard literature search engines – PubMed, Google Scholar, Science Direct. A standard set of keywords related to our topic e.g. “Depression”, “Mesembrine type alkaloids”, “Narcissus” was used. The review describes the classical monoamine theory of depression and connects it with the newly found biochemical, genetic and morphological alterations associated with the major depressive disorder. The purpose of this review is to highlight the most important aspects of the pathophysiology of depression and to explore the possibilities to use mesembrine-like alkaloids isolated from Narcissus cv. Hawera in its treatment. We describe their effect on brain biochemistry and possible future investigations.Bakalov D.Hadjiolova R.Pechlivanova D.Sciendoarticledepressionmesembrine type alkaloidsnarcissusphytomedicineMedicineRENActa Medica Bulgarica, Vol 47, Iss 4, Pp 69-74 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	depression mesembrine type alkaloids narcissus phytomedicine Medicine R
spellingShingle	depression mesembrine type alkaloids narcissus phytomedicine Medicine R Bakalov D. Hadjiolova R. Pechlivanova D. Pathophysiology of Depression and Novel Sources of Phytochemicals for its Treatment – A Systematic Review
description	The rising burden of depression, which will soon be the second most common cause of disability in the world, is requesting new ways to treat and prevent it. Due to high number of significant adverse drug reactions of the conventional treatment, the modern pharmaceutical industry is more often turning their focus to novel plant-based solutions. We performed literature research based on standard literature search engines – PubMed, Google Scholar, Science Direct. A standard set of keywords related to our topic e.g. “Depression”, “Mesembrine type alkaloids”, “Narcissus” was used. The review describes the classical monoamine theory of depression and connects it with the newly found biochemical, genetic and morphological alterations associated with the major depressive disorder. The purpose of this review is to highlight the most important aspects of the pathophysiology of depression and to explore the possibilities to use mesembrine-like alkaloids isolated from Narcissus cv. Hawera in its treatment. We describe their effect on brain biochemistry and possible future investigations.
format	article
author	Bakalov D. Hadjiolova R. Pechlivanova D.
author_facet	Bakalov D. Hadjiolova R. Pechlivanova D.
author_sort	Bakalov D.
title	Pathophysiology of Depression and Novel Sources of Phytochemicals for its Treatment – A Systematic Review
title_short	Pathophysiology of Depression and Novel Sources of Phytochemicals for its Treatment – A Systematic Review
title_full	Pathophysiology of Depression and Novel Sources of Phytochemicals for its Treatment – A Systematic Review
title_fullStr	Pathophysiology of Depression and Novel Sources of Phytochemicals for its Treatment – A Systematic Review
title_full_unstemmed	Pathophysiology of Depression and Novel Sources of Phytochemicals for its Treatment – A Systematic Review
title_sort	pathophysiology of depression and novel sources of phytochemicals for its treatment – a systematic review
publisher	Sciendo
publishDate	2020
url	https://doaj.org/article/45a66de35d274fdea88e0031d77e8676
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Pathophysiology of Depression and Novel Sources of Phytochemicals for its Treatment – A Systematic Review

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