Characterization of the oxidative metabolism of erythrocytes in patients with community-acquired pneumonia

Free radical oxidation plays an important role in the development and exacerbation of the pathological process. Oxidative stress causes a disturbance of the rheological properties of red blood cells and modification of their membrane. Activation of processes of peroxidation of lipids disturbs the in...

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Autores principales:	L. A. Demidchik, L. E. Muravlyova, V. B. Molotov-Luchanskiy, R. E. Bakirova, D. A. Kluyev, E. A. Kolesnikova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2016
Materias:	community-acquired pneumonia erythrocytes oxidative stress Science Q
Acceso en línea:	https://doaj.org/article/45aaa387b1f34d2390ec4e0fe1de178e
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spelling	oai:doaj.org-article:45aaa387b1f34d2390ec4e0fe1de178e2021-11-23T06:14:34ZCharacterization of the oxidative metabolism of erythrocytes in patients with community-acquired pneumonia2541-94202587-959610.12737/article_590823a41c1697.33018740https://doaj.org/article/45aaa387b1f34d2390ec4e0fe1de178e2016-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/180https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Free radical oxidation plays an important role in the development and exacerbation of the pathological process. Oxidative stress causes a disturbance of the rheological properties of red blood cells and modification of their membrane. Activation of processes of peroxidation of lipids disturbs the integrity of the erythrocyte membrane. In community-acquired pneumonia the study of oxidative metabolism of red blood cells, especially the oxidative modification of their proteins, dedicated to a limited number of studies. Oxidative modification of hemoglobin dissipate a key role in the development of inflammation induced by hypoxia. The aim of the research was to study indicators of oxidative stress, the content of oxidized modified proteins in the red blood cells and the permeability of their membranes to low-molecular-weight hydrophilic substances in patients with community-acquired pneumonia. The object of the study were the erythrocytes of blood of 33 patients with community-acquired pneumonia and 19 practically healthy persons of young and middle age from 27 to 42 years. Evidence of oxidative processes in red blood cells was a significant increase of the oxidized-modified proteins (carbonyl derivatives) in erythrocytes. The increase in the content of membrane-bound hemoglobin may also be due to the high level of lipid peroxidation in erythrocyte membranes. The results of the study showed the presence of intracellular oxidative stress in erythrocytes of patients with community-acquired pneumonia, which leads to damage to their membranes and release of hemoglobin into the blood plasma.L. A. DemidchikL. E. MuravlyovaV. B. Molotov-LuchanskiyR. E. BakirovaD. A. KluyevE. A. KolesnikovaScientific Сentre for Family Health and Human Reproduction Problemsarticlecommunity-acquired pneumoniaerythrocytesoxidative stressScienceQRUActa Biomedica Scientifica, Vol 1, Iss 3(2), Pp 26-28 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	community-acquired pneumonia erythrocytes oxidative stress Science Q
spellingShingle	community-acquired pneumonia erythrocytes oxidative stress Science Q L. A. Demidchik L. E. Muravlyova V. B. Molotov-Luchanskiy R. E. Bakirova D. A. Kluyev E. A. Kolesnikova Characterization of the oxidative metabolism of erythrocytes in patients with community-acquired pneumonia
description	Free radical oxidation plays an important role in the development and exacerbation of the pathological process. Oxidative stress causes a disturbance of the rheological properties of red blood cells and modification of their membrane. Activation of processes of peroxidation of lipids disturbs the integrity of the erythrocyte membrane. In community-acquired pneumonia the study of oxidative metabolism of red blood cells, especially the oxidative modification of their proteins, dedicated to a limited number of studies. Oxidative modification of hemoglobin dissipate a key role in the development of inflammation induced by hypoxia. The aim of the research was to study indicators of oxidative stress, the content of oxidized modified proteins in the red blood cells and the permeability of their membranes to low-molecular-weight hydrophilic substances in patients with community-acquired pneumonia. The object of the study were the erythrocytes of blood of 33 patients with community-acquired pneumonia and 19 practically healthy persons of young and middle age from 27 to 42 years. Evidence of oxidative processes in red blood cells was a significant increase of the oxidized-modified proteins (carbonyl derivatives) in erythrocytes. The increase in the content of membrane-bound hemoglobin may also be due to the high level of lipid peroxidation in erythrocyte membranes. The results of the study showed the presence of intracellular oxidative stress in erythrocytes of patients with community-acquired pneumonia, which leads to damage to their membranes and release of hemoglobin into the blood plasma.
format	article
author	L. A. Demidchik L. E. Muravlyova V. B. Molotov-Luchanskiy R. E. Bakirova D. A. Kluyev E. A. Kolesnikova
author_facet	L. A. Demidchik L. E. Muravlyova V. B. Molotov-Luchanskiy R. E. Bakirova D. A. Kluyev E. A. Kolesnikova
author_sort	L. A. Demidchik
title	Characterization of the oxidative metabolism of erythrocytes in patients with community-acquired pneumonia
title_short	Characterization of the oxidative metabolism of erythrocytes in patients with community-acquired pneumonia
title_full	Characterization of the oxidative metabolism of erythrocytes in patients with community-acquired pneumonia
title_fullStr	Characterization of the oxidative metabolism of erythrocytes in patients with community-acquired pneumonia
title_full_unstemmed	Characterization of the oxidative metabolism of erythrocytes in patients with community-acquired pneumonia
title_sort	characterization of the oxidative metabolism of erythrocytes in patients with community-acquired pneumonia
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2016
url	https://doaj.org/article/45aaa387b1f34d2390ec4e0fe1de178e
work_keys_str_mv	AT lademidchik characterizationoftheoxidativemetabolismoferythrocytesinpatientswithcommunityacquiredpneumonia AT lemuravlyova characterizationoftheoxidativemetabolismoferythrocytesinpatientswithcommunityacquiredpneumonia AT vbmolotovluchanskiy characterizationoftheoxidativemetabolismoferythrocytesinpatientswithcommunityacquiredpneumonia AT rebakirova characterizationoftheoxidativemetabolismoferythrocytesinpatientswithcommunityacquiredpneumonia AT dakluyev characterizationoftheoxidativemetabolismoferythrocytesinpatientswithcommunityacquiredpneumonia AT eakolesnikova characterizationoftheoxidativemetabolismoferythrocytesinpatientswithcommunityacquiredpneumonia
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Characterization of the oxidative metabolism of erythrocytes in patients with community-acquired pneumonia

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