A comparison between the efficacy of OCPLD with or without GnRH agonist on ovarian response in patients with PCOs

Background and Objective: Polycystic ovary syndrome (PCOs) has been studied for years but the most intriguing issue of PCOs that is causal factors affecting on ovarian function are still unknown. Neuroendocrine drug therapies, which affect on ovarian and adrenal function, are currently used for trea...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	A Ghasemi Nejad, L Mohammad Davoudi
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2003
Materias:	polycystic ovary syndrome oral contraceptive hirsutism Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/45ab14062a634ed2a160f03e6fe803ac
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:45ab14062a634ed2a160f03e6fe803ac
record_format	dspace
spelling	oai:doaj.org-article:45ab14062a634ed2a160f03e6fe803ac2021-11-10T09:18:00ZA comparison between the efficacy of OCPLD with or without GnRH agonist on ovarian response in patients with PCOs1561-41072251-7170https://doaj.org/article/45ab14062a634ed2a160f03e6fe803ac2003-01-01T00:00:00Zhttp://jbums.org/article-1-2793-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170Background and Objective: Polycystic ovary syndrome (PCOs) has been studied for years but the most intriguing issue of PCOs that is causal factors affecting on ovarian function are still unknown. Neuroendocrine drug therapies, which affect on ovarian and adrenal function, are currently used for treating patients with PCOs. Methods: This controlled clinical trial was done on 60 patients with PCOs referred to Mirza Koochak Khan hospital in Tehran during 2000-2001. Hormonal tests and the degree of hirsutism (Freeman-Galloway score) and medium diameter of ovaries were monitored by abdominal sonography at third day of the first menstruation during 6-month treatment. Patients were randomly divided into two groups (Each group 30 persons). First and second groups were treated with OCPLD and OCPLD with GnRH agonist, respectively. Findings: Both therapeutical regimens were effective in reducing androgen levels, Freeman Galloway score and medium ovarian diameters during 6-month treatment. However, this reduction in second group in comparison to first group was significantly more. This reduction of plasma testosterone, androstenedione, LH/FSH, medium diameters of ovaries and hirsutism in second group was significantly more than first group. Conclusion: According to the obtained data, it could be concluded that efficacy of the combined regimen (GnRHagonist+OCPLD) is higher than OCPLD alone in treatment of patients with PCOs.A Ghasemi NejadL Mohammad DavoudiBabol University of Medical Sciencesarticlepolycystic ovary syndromeoral contraceptivehirsutismMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 5, Iss 1, Pp 7-11 (2003)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	polycystic ovary syndrome oral contraceptive hirsutism Medicine R Medicine (General) R5-920
spellingShingle	polycystic ovary syndrome oral contraceptive hirsutism Medicine R Medicine (General) R5-920 A Ghasemi Nejad L Mohammad Davoudi A comparison between the efficacy of OCPLD with or without GnRH agonist on ovarian response in patients with PCOs
description	Background and Objective: Polycystic ovary syndrome (PCOs) has been studied for years but the most intriguing issue of PCOs that is causal factors affecting on ovarian function are still unknown. Neuroendocrine drug therapies, which affect on ovarian and adrenal function, are currently used for treating patients with PCOs. Methods: This controlled clinical trial was done on 60 patients with PCOs referred to Mirza Koochak Khan hospital in Tehran during 2000-2001. Hormonal tests and the degree of hirsutism (Freeman-Galloway score) and medium diameter of ovaries were monitored by abdominal sonography at third day of the first menstruation during 6-month treatment. Patients were randomly divided into two groups (Each group 30 persons). First and second groups were treated with OCPLD and OCPLD with GnRH agonist, respectively. Findings: Both therapeutical regimens were effective in reducing androgen levels, Freeman Galloway score and medium ovarian diameters during 6-month treatment. However, this reduction in second group in comparison to first group was significantly more. This reduction of plasma testosterone, androstenedione, LH/FSH, medium diameters of ovaries and hirsutism in second group was significantly more than first group. Conclusion: According to the obtained data, it could be concluded that efficacy of the combined regimen (GnRHagonist+OCPLD) is higher than OCPLD alone in treatment of patients with PCOs.
format	article
author	A Ghasemi Nejad L Mohammad Davoudi
author_facet	A Ghasemi Nejad L Mohammad Davoudi
author_sort	A Ghasemi Nejad
title	A comparison between the efficacy of OCPLD with or without GnRH agonist on ovarian response in patients with PCOs
title_short	A comparison between the efficacy of OCPLD with or without GnRH agonist on ovarian response in patients with PCOs
title_full	A comparison between the efficacy of OCPLD with or without GnRH agonist on ovarian response in patients with PCOs
title_fullStr	A comparison between the efficacy of OCPLD with or without GnRH agonist on ovarian response in patients with PCOs
title_full_unstemmed	A comparison between the efficacy of OCPLD with or without GnRH agonist on ovarian response in patients with PCOs
title_sort	comparison between the efficacy of ocpld with or without gnrh agonist on ovarian response in patients with pcos
publisher	Babol University of Medical Sciences
publishDate	2003
url	https://doaj.org/article/45ab14062a634ed2a160f03e6fe803ac
work_keys_str_mv	AT aghaseminejad acomparisonbetweentheefficacyofocpldwithorwithoutgnrhagonistonovarianresponseinpatientswithpcos AT lmohammaddavoudi acomparisonbetweentheefficacyofocpldwithorwithoutgnrhagonistonovarianresponseinpatientswithpcos AT aghaseminejad comparisonbetweentheefficacyofocpldwithorwithoutgnrhagonistonovarianresponseinpatientswithpcos AT lmohammaddavoudi comparisonbetweentheefficacyofocpldwithorwithoutgnrhagonistonovarianresponseinpatientswithpcos
_version_	1718440187276558336

A comparison between the efficacy of OCPLD with or without GnRH agonist on ovarian response in patients with PCOs

Ejemplares similares