Neural responses in retrosplenial cortex associated with environmental alterations

Summary: The retrosplenial cortex (RSC) is an area interconnected with regions of the brain that display spatial correlates. Neurons in connected regions may encode an animal’s position in the environment and location or proximity to objects or boundaries. RSC has also been shown to be important for...

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Autores principales:	Lucas C. Carstensen, Andrew S. Alexander, G. William Chapman, Aubrey J. Lee, Michael E. Hasselmo
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Animal physiology Neuroscience Behavioral neuroscience Cellular neuroscience Science Q
Acceso en línea:	https://doaj.org/article/45ab97afbe9d4d44b61aed656da1de4b
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spelling	oai:doaj.org-article:45ab97afbe9d4d44b61aed656da1de4b2021-11-20T05:10:53ZNeural responses in retrosplenial cortex associated with environmental alterations2589-004210.1016/j.isci.2021.103377https://doaj.org/article/45ab97afbe9d4d44b61aed656da1de4b2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221013481https://doaj.org/toc/2589-0042Summary: The retrosplenial cortex (RSC) is an area interconnected with regions of the brain that display spatial correlates. Neurons in connected regions may encode an animal’s position in the environment and location or proximity to objects or boundaries. RSC has also been shown to be important for spatial memory, such as tracking distance from and between landmarks, contextual information, and orientation within an environment. For these reasons, it is important to determine how neurons in RSC represent cues such as objects or boundaries and their relationship to the environment. In the current work, we performed electrophysiological recordings in RSC, whereas rats foraged in arenas that could contain an object or in which the environment was altered. We report RSC neurons display changes in mean firing rate responding to alterations of the environment. These alterations include the arena rotating, changing size or shape, or an object being introduced into the arena.Lucas C. CarstensenAndrew S. AlexanderG. William ChapmanAubrey J. LeeMichael E. HasselmoElsevierarticleAnimal physiologyNeuroscienceBehavioral neuroscienceCellular neuroscienceScienceQENiScience, Vol 24, Iss 11, Pp 103377- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Animal physiology Neuroscience Behavioral neuroscience Cellular neuroscience Science Q
spellingShingle	Animal physiology Neuroscience Behavioral neuroscience Cellular neuroscience Science Q Lucas C. Carstensen Andrew S. Alexander G. William Chapman Aubrey J. Lee Michael E. Hasselmo Neural responses in retrosplenial cortex associated with environmental alterations
description	Summary: The retrosplenial cortex (RSC) is an area interconnected with regions of the brain that display spatial correlates. Neurons in connected regions may encode an animal’s position in the environment and location or proximity to objects or boundaries. RSC has also been shown to be important for spatial memory, such as tracking distance from and between landmarks, contextual information, and orientation within an environment. For these reasons, it is important to determine how neurons in RSC represent cues such as objects or boundaries and their relationship to the environment. In the current work, we performed electrophysiological recordings in RSC, whereas rats foraged in arenas that could contain an object or in which the environment was altered. We report RSC neurons display changes in mean firing rate responding to alterations of the environment. These alterations include the arena rotating, changing size or shape, or an object being introduced into the arena.
format	article
author	Lucas C. Carstensen Andrew S. Alexander G. William Chapman Aubrey J. Lee Michael E. Hasselmo
author_facet	Lucas C. Carstensen Andrew S. Alexander G. William Chapman Aubrey J. Lee Michael E. Hasselmo
author_sort	Lucas C. Carstensen
title	Neural responses in retrosplenial cortex associated with environmental alterations
title_short	Neural responses in retrosplenial cortex associated with environmental alterations
title_full	Neural responses in retrosplenial cortex associated with environmental alterations
title_fullStr	Neural responses in retrosplenial cortex associated with environmental alterations
title_full_unstemmed	Neural responses in retrosplenial cortex associated with environmental alterations
title_sort	neural responses in retrosplenial cortex associated with environmental alterations
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/45ab97afbe9d4d44b61aed656da1de4b
work_keys_str_mv	AT lucasccarstensen neuralresponsesinretrosplenialcortexassociatedwithenvironmentalalterations AT andrewsalexander neuralresponsesinretrosplenialcortexassociatedwithenvironmentalalterations AT gwilliamchapman neuralresponsesinretrosplenialcortexassociatedwithenvironmentalalterations AT aubreyjlee neuralresponsesinretrosplenialcortexassociatedwithenvironmentalalterations AT michaelehasselmo neuralresponsesinretrosplenialcortexassociatedwithenvironmentalalterations
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Neural responses in retrosplenial cortex associated with environmental alterations

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