Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias

Acute myeloid leukaemia (AML) affects people of all ages. Here, the authors model AML in vivo and demonstrate that the age of the cell of origin impacts leukaemia development and the genetic signature where adult cells of origin give rise exclusively to AML and young cells of origin give rise to mye...

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Autores principales:	Shahzya Chaudhury, Caitríona O’Connor, Ana Cañete, Joana Bittencourt-Silvestre, Evgenia Sarrou, Áine Prendergast, Jarny Choi, Pamela Johnston, Christine A. Wells, Brenda Gibson, Karen Keeshan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/45ac5ba4169748aa87db7465b7797c49
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spelling	oai:doaj.org-article:45ac5ba4169748aa87db7465b7797c492021-12-02T14:41:17ZAge-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias10.1038/s41467-018-07584-12041-1723https://doaj.org/article/45ac5ba4169748aa87db7465b7797c492018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07584-1https://doaj.org/toc/2041-1723Acute myeloid leukaemia (AML) affects people of all ages. Here, the authors model AML in vivo and demonstrate that the age of the cell of origin impacts leukaemia development and the genetic signature where adult cells of origin give rise exclusively to AML and young cells of origin give rise to myeloid, lymphoid or mixed phenotype acute leukaemia.Shahzya ChaudhuryCaitríona O’ConnorAna CañeteJoana Bittencourt-SilvestreEvgenia SarrouÁine PrendergastJarny ChoiPamela JohnstonChristine A. WellsBrenda GibsonKaren KeeshanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shahzya Chaudhury Caitríona O’Connor Ana Cañete Joana Bittencourt-Silvestre Evgenia Sarrou Áine Prendergast Jarny Choi Pamela Johnston Christine A. Wells Brenda Gibson Karen Keeshan Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias
description	Acute myeloid leukaemia (AML) affects people of all ages. Here, the authors model AML in vivo and demonstrate that the age of the cell of origin impacts leukaemia development and the genetic signature where adult cells of origin give rise exclusively to AML and young cells of origin give rise to myeloid, lymphoid or mixed phenotype acute leukaemia.
format	article
author	Shahzya Chaudhury Caitríona O’Connor Ana Cañete Joana Bittencourt-Silvestre Evgenia Sarrou Áine Prendergast Jarny Choi Pamela Johnston Christine A. Wells Brenda Gibson Karen Keeshan
author_facet	Shahzya Chaudhury Caitríona O’Connor Ana Cañete Joana Bittencourt-Silvestre Evgenia Sarrou Áine Prendergast Jarny Choi Pamela Johnston Christine A. Wells Brenda Gibson Karen Keeshan
author_sort	Shahzya Chaudhury
title	Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias
title_short	Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias
title_full	Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias
title_fullStr	Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias
title_full_unstemmed	Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias
title_sort	age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/45ac5ba4169748aa87db7465b7797c49
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Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias

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