Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias

Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias

Acute myeloid leukaemia (AML) affects people of all ages. Here, the authors model AML in vivo and demonstrate that the age of the cell of origin impacts leukaemia development and the genetic signature where adult cells of origin give rise exclusively to AML and young cells of origin give rise to mye...

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Autores principales: Shahzya Chaudhury, Caitríona O’Connor, Ana Cañete, Joana Bittencourt-Silvestre, Evgenia Sarrou, Áine Prendergast, Jarny Choi, Pamela Johnston, Christine A. Wells, Brenda Gibson, Karen Keeshan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/45ac5ba4169748aa87db7465b7797c49
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