Genetic contribution to lipid levels in early life based on 158 loci validated in adults: the FAMILY study

Abstract The contribution of polymorphisms associated with adult lipids in early life is unknown. We studied 158 adult lipid polymorphisms in 1440 participants (544 children, 544 mothers and 324 fathers) of the Family Atherosclerosis Monitoring In early life (FAMILY) birth cohort. Total cholesterol...

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Autores principales:	Shanice Christie, Sébastien Robiou-du-Pont, Sonia S. Anand, Katherine M. Morrison, Sarah D. McDonald, Guillaume Paré, Stephanie A. Atkinson, Koon K. Teo, David Meyre
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/45aec85873a44be3a58c313e12bb37cc
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spelling	oai:doaj.org-article:45aec85873a44be3a58c313e12bb37cc2021-12-02T16:07:01ZGenetic contribution to lipid levels in early life based on 158 loci validated in adults: the FAMILY study10.1038/s41598-017-00102-12045-2322https://doaj.org/article/45aec85873a44be3a58c313e12bb37cc2017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00102-1https://doaj.org/toc/2045-2322Abstract The contribution of polymorphisms associated with adult lipids in early life is unknown. We studied 158 adult lipid polymorphisms in 1440 participants (544 children, 544 mothers and 324 fathers) of the Family Atherosclerosis Monitoring In early life (FAMILY) birth cohort. Total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG) measurements were collected at birth, 3 and 5 years of age. Polymorphisms were genotyped using the Illumina Cardio-Metabochip array. Genotype scores (GS) were calculated for TC, HDL-C, LDL-C and TG. Linear and mixed-effects regressions adjusted for sex, age and population stratification were performed. The GS was associated with LDL-C level at 3 and 5 years (β = 0.017 ± 0.003, P = 2.9 × 10−8; β = 0.020 ± 0.003, P = 5.7 × 10−9) and from birth to 5 years (β = 0.013 ± 0.003, P = 2.6 × 10−7). The GS was associated with TC level at 3 and 5 years (β = 0.009 ± 0.002, P = 9.1 × 10−7; β = 0.009 ± 0.002, P = 7.7 × 10−6). CETP rs3764261 was associated with the HDL-C level from birth to 5 years (β = 0.064 ± 0.014, P = 7.4 × 10−6). AMPD3 rs2923084 was associated with the HDL-C level at 5 years (β = 0.096 ± 0.024, P = 9.7 × 10−5). Known loci associated with blood lipids in adults are associated with TC, LDL-C and HDL-C, but not TG in early life. Genetically predisposed children may benefit from early lipid lowering preventative strategies.Shanice ChristieSébastien Robiou-du-PontSonia S. AnandKatherine M. MorrisonSarah D. McDonaldGuillaume ParéStephanie A. AtkinsonKoon K. TeoDavid MeyreNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shanice Christie Sébastien Robiou-du-Pont Sonia S. Anand Katherine M. Morrison Sarah D. McDonald Guillaume Paré Stephanie A. Atkinson Koon K. Teo David Meyre Genetic contribution to lipid levels in early life based on 158 loci validated in adults: the FAMILY study
description	Abstract The contribution of polymorphisms associated with adult lipids in early life is unknown. We studied 158 adult lipid polymorphisms in 1440 participants (544 children, 544 mothers and 324 fathers) of the Family Atherosclerosis Monitoring In early life (FAMILY) birth cohort. Total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG) measurements were collected at birth, 3 and 5 years of age. Polymorphisms were genotyped using the Illumina Cardio-Metabochip array. Genotype scores (GS) were calculated for TC, HDL-C, LDL-C and TG. Linear and mixed-effects regressions adjusted for sex, age and population stratification were performed. The GS was associated with LDL-C level at 3 and 5 years (β = 0.017 ± 0.003, P = 2.9 × 10−8; β = 0.020 ± 0.003, P = 5.7 × 10−9) and from birth to 5 years (β = 0.013 ± 0.003, P = 2.6 × 10−7). The GS was associated with TC level at 3 and 5 years (β = 0.009 ± 0.002, P = 9.1 × 10−7; β = 0.009 ± 0.002, P = 7.7 × 10−6). CETP rs3764261 was associated with the HDL-C level from birth to 5 years (β = 0.064 ± 0.014, P = 7.4 × 10−6). AMPD3 rs2923084 was associated with the HDL-C level at 5 years (β = 0.096 ± 0.024, P = 9.7 × 10−5). Known loci associated with blood lipids in adults are associated with TC, LDL-C and HDL-C, but not TG in early life. Genetically predisposed children may benefit from early lipid lowering preventative strategies.
format	article
author	Shanice Christie Sébastien Robiou-du-Pont Sonia S. Anand Katherine M. Morrison Sarah D. McDonald Guillaume Paré Stephanie A. Atkinson Koon K. Teo David Meyre
author_facet	Shanice Christie Sébastien Robiou-du-Pont Sonia S. Anand Katherine M. Morrison Sarah D. McDonald Guillaume Paré Stephanie A. Atkinson Koon K. Teo David Meyre
author_sort	Shanice Christie
title	Genetic contribution to lipid levels in early life based on 158 loci validated in adults: the FAMILY study
title_short	Genetic contribution to lipid levels in early life based on 158 loci validated in adults: the FAMILY study
title_full	Genetic contribution to lipid levels in early life based on 158 loci validated in adults: the FAMILY study
title_fullStr	Genetic contribution to lipid levels in early life based on 158 loci validated in adults: the FAMILY study
title_full_unstemmed	Genetic contribution to lipid levels in early life based on 158 loci validated in adults: the FAMILY study
title_sort	genetic contribution to lipid levels in early life based on 158 loci validated in adults: the family study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/45aec85873a44be3a58c313e12bb37cc
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Genetic contribution to lipid levels in early life based on 158 loci validated in adults: the FAMILY study

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