RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair

Antigen receptor diversity relies on careful DNA cleavage and repair. Here the authors identify a functional interplay between RAG2 and XLF during V(D)J recombination, revealing an important role for the RAG complex in repairing induced DNA double-strand breaks and maintaining genome integrity.

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Autores principales:	Chloé Lescale, Vincent Abramowski, Marie Bedora-Faure, Valentine Murigneux, Gabriella Vera, David B. Roth, Patrick Revy, Jean-Pierre de Villartay, Ludovic Deriano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/45b3d85d8e094ec8ba4c1f14631de376
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spelling	oai:doaj.org-article:45b3d85d8e094ec8ba4c1f14631de3762021-12-02T15:35:46ZRAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair10.1038/ncomms105292041-1723https://doaj.org/article/45b3d85d8e094ec8ba4c1f14631de3762016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10529https://doaj.org/toc/2041-1723Antigen receptor diversity relies on careful DNA cleavage and repair. Here the authors identify a functional interplay between RAG2 and XLF during V(D)J recombination, revealing an important role for the RAG complex in repairing induced DNA double-strand breaks and maintaining genome integrity.Chloé LescaleVincent AbramowskiMarie Bedora-FaureValentine MurigneuxGabriella VeraDavid B. RothPatrick RevyJean-Pierre de VillartayLudovic DerianoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chloé Lescale Vincent Abramowski Marie Bedora-Faure Valentine Murigneux Gabriella Vera David B. Roth Patrick Revy Jean-Pierre de Villartay Ludovic Deriano RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair
description	Antigen receptor diversity relies on careful DNA cleavage and repair. Here the authors identify a functional interplay between RAG2 and XLF during V(D)J recombination, revealing an important role for the RAG complex in repairing induced DNA double-strand breaks and maintaining genome integrity.
format	article
author	Chloé Lescale Vincent Abramowski Marie Bedora-Faure Valentine Murigneux Gabriella Vera David B. Roth Patrick Revy Jean-Pierre de Villartay Ludovic Deriano
author_facet	Chloé Lescale Vincent Abramowski Marie Bedora-Faure Valentine Murigneux Gabriella Vera David B. Roth Patrick Revy Jean-Pierre de Villartay Ludovic Deriano
author_sort	Chloé Lescale
title	RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair
title_short	RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair
title_full	RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair
title_fullStr	RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair
title_full_unstemmed	RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair
title_sort	rag2 and xlf/cernunnos interplay reveals a novel role for the rag complex in dna repair
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/45b3d85d8e094ec8ba4c1f14631de376
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RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair

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