RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair

RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair

Antigen receptor diversity relies on careful DNA cleavage and repair. Here the authors identify a functional interplay between RAG2 and XLF during V(D)J recombination, revealing an important role for the RAG complex in repairing induced DNA double-strand breaks and maintaining genome integrity.

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Detalles Bibliográficos
Autores principales: Chloé Lescale, Vincent Abramowski, Marie Bedora-Faure, Valentine Murigneux, Gabriella Vera, David B. Roth, Patrick Revy, Jean-Pierre de Villartay, Ludovic Deriano
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/45b3d85d8e094ec8ba4c1f14631de376
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