The prevalence and related factors of metabolic syndrome in outpatients with first-episode drug-naive major depression comorbid with anxiety
Abstract Metabolic syndrome (MetS) is associated with depression, but its role in major depressive disorder comorbid with anxiety (AMD) is unclear. This study aimed to investigate the prevalence and clinical correlates of MetS in first-episode drug-naive (FEDN) patients with AMD in a Chinese Han pop...
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Nature Portfolio
2021
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oai:doaj.org-article:45b407d966274a698231bc0218835bcc2021-12-02T12:14:56ZThe prevalence and related factors of metabolic syndrome in outpatients with first-episode drug-naive major depression comorbid with anxiety10.1038/s41598-021-81653-22045-2322https://doaj.org/article/45b407d966274a698231bc0218835bcc2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81653-2https://doaj.org/toc/2045-2322Abstract Metabolic syndrome (MetS) is associated with depression, but its role in major depressive disorder comorbid with anxiety (AMD) is unclear. This study aimed to investigate the prevalence and clinical correlates of MetS in first-episode drug-naive (FEDN) patients with AMD in a Chinese Han population. In total, 1380 FEDN outpatients with AMD were recruited in this cross-sectional study. The sociodemographic features, clinical characteristics, history of suicide attempts, thyroid-stimulating hormone (TSH) levels, and MetS parameters of each subject were evaluated. All subjects were rated on the Hamilton Depression Rating Scale (HAM-D), Hamilton Anxiety Rating Scale (HAM-A), and the Positive and Negative Syndrome Scale positive symptom subscale. The prevalence of MetS among AMD patients was 8.04%. Compared to the non-MetS group, age, age of onset, TSH level, HAM-A and HAM-D scores, history of attempted suicide, and comorbid psychiatric symptoms were higher in the MetS group. Those in this group were also more likely to be married, and they had a lower educational level. Furthermore, age, psychiatric symptoms, suicide attempts, and higher TSH levels were independently associated with MetS in AMD patients. This study suggests a lower prevalence of MetS in FEDN patients with AMD in a Chinese Han population. Older age, comorbid psychiatric symptoms, history of attempted suicide, and higher TSH levels are related factors for MetS in AMD patients.Yinghua ZhongManji HuQiang WangZhendong YangNa ZhuFei WangXiyan ZhangChengfang ZhangJie MinHao WangFazhan ChenXudong ZhaoXiangyang ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) |
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Medicine R Science Q Yinghua Zhong Manji Hu Qiang Wang Zhendong Yang Na Zhu Fei Wang Xiyan Zhang Chengfang Zhang Jie Min Hao Wang Fazhan Chen Xudong Zhao Xiangyang Zhang The prevalence and related factors of metabolic syndrome in outpatients with first-episode drug-naive major depression comorbid with anxiety |
| description |
Abstract Metabolic syndrome (MetS) is associated with depression, but its role in major depressive disorder comorbid with anxiety (AMD) is unclear. This study aimed to investigate the prevalence and clinical correlates of MetS in first-episode drug-naive (FEDN) patients with AMD in a Chinese Han population. In total, 1380 FEDN outpatients with AMD were recruited in this cross-sectional study. The sociodemographic features, clinical characteristics, history of suicide attempts, thyroid-stimulating hormone (TSH) levels, and MetS parameters of each subject were evaluated. All subjects were rated on the Hamilton Depression Rating Scale (HAM-D), Hamilton Anxiety Rating Scale (HAM-A), and the Positive and Negative Syndrome Scale positive symptom subscale. The prevalence of MetS among AMD patients was 8.04%. Compared to the non-MetS group, age, age of onset, TSH level, HAM-A and HAM-D scores, history of attempted suicide, and comorbid psychiatric symptoms were higher in the MetS group. Those in this group were also more likely to be married, and they had a lower educational level. Furthermore, age, psychiatric symptoms, suicide attempts, and higher TSH levels were independently associated with MetS in AMD patients. This study suggests a lower prevalence of MetS in FEDN patients with AMD in a Chinese Han population. Older age, comorbid psychiatric symptoms, history of attempted suicide, and higher TSH levels are related factors for MetS in AMD patients. |
| format |
article |
| author |
Yinghua Zhong Manji Hu Qiang Wang Zhendong Yang Na Zhu Fei Wang Xiyan Zhang Chengfang Zhang Jie Min Hao Wang Fazhan Chen Xudong Zhao Xiangyang Zhang |
| author_facet |
Yinghua Zhong Manji Hu Qiang Wang Zhendong Yang Na Zhu Fei Wang Xiyan Zhang Chengfang Zhang Jie Min Hao Wang Fazhan Chen Xudong Zhao Xiangyang Zhang |
| author_sort |
Yinghua Zhong |
| title |
The prevalence and related factors of metabolic syndrome in outpatients with first-episode drug-naive major depression comorbid with anxiety |
| title_short |
The prevalence and related factors of metabolic syndrome in outpatients with first-episode drug-naive major depression comorbid with anxiety |
| title_full |
The prevalence and related factors of metabolic syndrome in outpatients with first-episode drug-naive major depression comorbid with anxiety |
| title_fullStr |
The prevalence and related factors of metabolic syndrome in outpatients with first-episode drug-naive major depression comorbid with anxiety |
| title_full_unstemmed |
The prevalence and related factors of metabolic syndrome in outpatients with first-episode drug-naive major depression comorbid with anxiety |
| title_sort |
prevalence and related factors of metabolic syndrome in outpatients with first-episode drug-naive major depression comorbid with anxiety |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/45b407d966274a698231bc0218835bcc |
| work_keys_str_mv |
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