Interaction of Drugs Used for the Treatment of Cardiovascular Diseases

Combined therapy in cardiology is currently the most recognized method of treatment, especially in patients with hypertension. Approximately in 50 % of patients with hypertension, monotherapy is effective. However to achieve the desired effect in the remaining half of patients, simultaneous administ...

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Autores principales:	Galina N. Kovalskaya, Dina Y. Zhukova, Ekaterina N. Mikhalevich
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2019
Materias:	drug interaction combined therapy cardiovascular disease Science Q
Acceso en línea:	https://doaj.org/article/45b5616d11174f0fb5291a802fda7713
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spelling	oai:doaj.org-article:45b5616d11174f0fb5291a802fda77132021-11-23T06:14:42ZInteraction of Drugs Used for the Treatment of Cardiovascular Diseases2541-94202587-959610.29413/ABS.2019-4.1.6https://doaj.org/article/45b5616d11174f0fb5291a802fda77132019-04-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/1976https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Combined therapy in cardiology is currently the most recognized method of treatment, especially in patients with hypertension. Approximately in 50 % of patients with hypertension, monotherapy is effective. However to achieve the desired effect in the remaining half of patients, simultaneous administration of two and sometimes three drugs is required. Numerous drugs with a fixed combination of two (and even three) antihypertensive drugs, often used in clinical practice, greatly simplify the dosage regimen of drugs and improve patients’ adherence to treatment. Unfortunately, simultaneous prescription of several drugs increases sharply the probability of inter-drug interaction with the increase in the number of prescribed drugs. The result of drug-drug intereaction may be unpredictable. Therefore, the ability to predict the possible adverse reactions in patients with cardiovascular diseases and to prescribe rationally combined pharmacotherapy is a guarantee of highly efficient and safe treatment.Currently, rational combinations of antihypertensive drugs of different groups make hypertension therapy more comfortable and increases patients’ adherence to treatment. The authors present topical combinations of antihypertensive drugs in one drug: angiotensin converting enzyme inhibitor + diuretic, β-adrenoblocker + diuretic; diuretic + angiotensin receptor antagonist; calcium antagonist + angiotensin receptor antagonist; calcium antagonist + β-adrenoblocker, and others.The article presents an overview of both rational (calcium antagonist + diuretic, β-adrenoblocker + diuretic,) and irrational (angiotensin converting enzyme Inhibitor + potassium-sparing diuretic, angiotensin receptor blocker + potassium-sparing diuretic) combinations of antihypertensive drugs. Combinations of some hypotensive and antianginal drugs with drugs of other groups with a high risk of adverse reactions are presented.Galina N. KovalskayaDina Y. ZhukovaEkaterina N. MikhalevichScientific Сentre for Family Health and Human Reproduction Problemsarticledruginteractioncombined therapycardiovascular diseaseScienceQRUActa Biomedica Scientifica, Vol 4, Iss 1, Pp 36-42 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	drug interaction combined therapy cardiovascular disease Science Q
spellingShingle	drug interaction combined therapy cardiovascular disease Science Q Galina N. Kovalskaya Dina Y. Zhukova Ekaterina N. Mikhalevich Interaction of Drugs Used for the Treatment of Cardiovascular Diseases
description	Combined therapy in cardiology is currently the most recognized method of treatment, especially in patients with hypertension. Approximately in 50 % of patients with hypertension, monotherapy is effective. However to achieve the desired effect in the remaining half of patients, simultaneous administration of two and sometimes three drugs is required. Numerous drugs with a fixed combination of two (and even three) antihypertensive drugs, often used in clinical practice, greatly simplify the dosage regimen of drugs and improve patients’ adherence to treatment. Unfortunately, simultaneous prescription of several drugs increases sharply the probability of inter-drug interaction with the increase in the number of prescribed drugs. The result of drug-drug intereaction may be unpredictable. Therefore, the ability to predict the possible adverse reactions in patients with cardiovascular diseases and to prescribe rationally combined pharmacotherapy is a guarantee of highly efficient and safe treatment.Currently, rational combinations of antihypertensive drugs of different groups make hypertension therapy more comfortable and increases patients’ adherence to treatment. The authors present topical combinations of antihypertensive drugs in one drug: angiotensin converting enzyme inhibitor + diuretic, β-adrenoblocker + diuretic; diuretic + angiotensin receptor antagonist; calcium antagonist + angiotensin receptor antagonist; calcium antagonist + β-adrenoblocker, and others.The article presents an overview of both rational (calcium antagonist + diuretic, β-adrenoblocker + diuretic,) and irrational (angiotensin converting enzyme Inhibitor + potassium-sparing diuretic, angiotensin receptor blocker + potassium-sparing diuretic) combinations of antihypertensive drugs. Combinations of some hypotensive and antianginal drugs with drugs of other groups with a high risk of adverse reactions are presented.
format	article
author	Galina N. Kovalskaya Dina Y. Zhukova Ekaterina N. Mikhalevich
author_facet	Galina N. Kovalskaya Dina Y. Zhukova Ekaterina N. Mikhalevich
author_sort	Galina N. Kovalskaya
title	Interaction of Drugs Used for the Treatment of Cardiovascular Diseases
title_short	Interaction of Drugs Used for the Treatment of Cardiovascular Diseases
title_full	Interaction of Drugs Used for the Treatment of Cardiovascular Diseases
title_fullStr	Interaction of Drugs Used for the Treatment of Cardiovascular Diseases
title_full_unstemmed	Interaction of Drugs Used for the Treatment of Cardiovascular Diseases
title_sort	interaction of drugs used for the treatment of cardiovascular diseases
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2019
url	https://doaj.org/article/45b5616d11174f0fb5291a802fda7713
work_keys_str_mv	AT galinankovalskaya interactionofdrugsusedforthetreatmentofcardiovasculardiseases AT dinayzhukova interactionofdrugsusedforthetreatmentofcardiovasculardiseases AT ekaterinanmikhalevich interactionofdrugsusedforthetreatmentofcardiovasculardiseases
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Interaction of Drugs Used for the Treatment of Cardiovascular Diseases

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