Vitamin D status during pregnancy and the risk of subsequent postpartum depression: a case-control study.

Epidemiological studies have provided evidence of an association between vitamin D insufficiency and depression and other mood disorders, and a role for vitamin D in various brain functions has been suggested. We hypothesized that low vitamin D status during pregnancy might increase the risk of post...

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Autores principales:	Nina O Nielsen, Marin Strøm, Heather A Boyd, Elisabeth W Andersen, Jan Wohlfahrt, Marika Lundqvist, Arieh Cohen, David M Hougaard, Mads Melbye
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/45b5cbb276574827a457e60dd2bb7293
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spelling	oai:doaj.org-article:45b5cbb276574827a457e60dd2bb72932021-11-18T08:44:26ZVitamin D status during pregnancy and the risk of subsequent postpartum depression: a case-control study.1932-620310.1371/journal.pone.0080686https://doaj.org/article/45b5cbb276574827a457e60dd2bb72932013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24312237/?tool=EBIhttps://doaj.org/toc/1932-6203Epidemiological studies have provided evidence of an association between vitamin D insufficiency and depression and other mood disorders, and a role for vitamin D in various brain functions has been suggested. We hypothesized that low vitamin D status during pregnancy might increase the risk of postpartum depression (PPD). The objective of the study was thus to determine whether low vitamin D status during pregnancy was associated with postpartum depression. In a case-control study nested in the Danish National Birth Cohort, we measured late pregnancy serum concentrations of 25[OH]D3 in 605 women with PPD and 875 controls. Odds ratios [OR) for PPD were calculated for six levels of 25[OH]D3. Overall, we found no association between vitamin D concentrations and risk of PPD (p = 0.08). Compared with women with vitamin D concentrations between 50 and 79 nmol/L, the adjusted odds ratios for PPD were 1.35 (95% CI: 0.64; 2.85), 0.83 (CI: 0.50; 1.39) and 1.13 (CI: 0.84; 1.51) among women with vitamin D concentrations < 15 nmol/L, 15-24 nmol/L and 25-49 nmol/L, respectively, and 1.53 (CI: 1.04; 2.26) and 1.89 (CI: 1.06; 3.37) among women with vitamin D concentrations of 80-99 nmol/L and ≥ 100 nmol/L, respectively. In an additional analysis among women with sufficient vitamin D (≥ 50 nmol/L), we observed a significant positive association between vitamin D concentrations and PPD. Our results did not support an association between low maternal vitamin D concentrations during pregnancy and risk of PPD. Instead, an increased risk of PPD was found among women with the highest vitamin D concentrations.Nina O NielsenMarin StrømHeather A BoydElisabeth W AndersenJan WohlfahrtMarika LundqvistArieh CohenDavid M HougaardMads MelbyePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e80686 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nina O Nielsen Marin Strøm Heather A Boyd Elisabeth W Andersen Jan Wohlfahrt Marika Lundqvist Arieh Cohen David M Hougaard Mads Melbye Vitamin D status during pregnancy and the risk of subsequent postpartum depression: a case-control study.
description	Epidemiological studies have provided evidence of an association between vitamin D insufficiency and depression and other mood disorders, and a role for vitamin D in various brain functions has been suggested. We hypothesized that low vitamin D status during pregnancy might increase the risk of postpartum depression (PPD). The objective of the study was thus to determine whether low vitamin D status during pregnancy was associated with postpartum depression. In a case-control study nested in the Danish National Birth Cohort, we measured late pregnancy serum concentrations of 25[OH]D3 in 605 women with PPD and 875 controls. Odds ratios [OR) for PPD were calculated for six levels of 25[OH]D3. Overall, we found no association between vitamin D concentrations and risk of PPD (p = 0.08). Compared with women with vitamin D concentrations between 50 and 79 nmol/L, the adjusted odds ratios for PPD were 1.35 (95% CI: 0.64; 2.85), 0.83 (CI: 0.50; 1.39) and 1.13 (CI: 0.84; 1.51) among women with vitamin D concentrations < 15 nmol/L, 15-24 nmol/L and 25-49 nmol/L, respectively, and 1.53 (CI: 1.04; 2.26) and 1.89 (CI: 1.06; 3.37) among women with vitamin D concentrations of 80-99 nmol/L and ≥ 100 nmol/L, respectively. In an additional analysis among women with sufficient vitamin D (≥ 50 nmol/L), we observed a significant positive association between vitamin D concentrations and PPD. Our results did not support an association between low maternal vitamin D concentrations during pregnancy and risk of PPD. Instead, an increased risk of PPD was found among women with the highest vitamin D concentrations.
format	article
author	Nina O Nielsen Marin Strøm Heather A Boyd Elisabeth W Andersen Jan Wohlfahrt Marika Lundqvist Arieh Cohen David M Hougaard Mads Melbye
author_facet	Nina O Nielsen Marin Strøm Heather A Boyd Elisabeth W Andersen Jan Wohlfahrt Marika Lundqvist Arieh Cohen David M Hougaard Mads Melbye
author_sort	Nina O Nielsen
title	Vitamin D status during pregnancy and the risk of subsequent postpartum depression: a case-control study.
title_short	Vitamin D status during pregnancy and the risk of subsequent postpartum depression: a case-control study.
title_full	Vitamin D status during pregnancy and the risk of subsequent postpartum depression: a case-control study.
title_fullStr	Vitamin D status during pregnancy and the risk of subsequent postpartum depression: a case-control study.
title_full_unstemmed	Vitamin D status during pregnancy and the risk of subsequent postpartum depression: a case-control study.
title_sort	vitamin d status during pregnancy and the risk of subsequent postpartum depression: a case-control study.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/45b5cbb276574827a457e60dd2bb7293
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Vitamin D status during pregnancy and the risk of subsequent postpartum depression: a case-control study.

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