<i>Rhaponticum uniflorum</i> and <i>Serratula centauroides</i> Extracts Attenuate Emotional Injury in Acute and Chronic Emotional Stress

In modern life, the use of plant stress-protectors has taken on particular significance due to the wide distribution of neurosis-like and neurotic diseases caused by neuroendocrine-immune system imbalance. Special attention has been paid to the plants containing ecdysteroids, i.e., hormone-like bioa...

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Autores principales:	Larisa N. Shantanova, Daniil N. Olennikov, Irinchey E. Matkhanov, Sergey M. Gulyaev, Anyuta A. Toropova, Irina G. Nikolaeva, Sergey M. Nikolaev
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Rhaponticum uniflorum</i> <i>Serratula centauroides</i> ecdysteroids caffeoylquinic acids emotional stress depression Medicine R Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/45b5ea7220774a3e8069265c5340ed33
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spelling	oai:doaj.org-article:45b5ea7220774a3e8069265c5340ed332021-11-25T18:40:02Z<i>Rhaponticum uniflorum</i> and <i>Serratula centauroides</i> Extracts Attenuate Emotional Injury in Acute and Chronic Emotional Stress10.3390/ph141111861424-8247https://doaj.org/article/45b5ea7220774a3e8069265c5340ed332021-11-01T00:00:00Zhttps://www.mdpi.com/1424-8247/14/11/1186https://doaj.org/toc/1424-8247In modern life, the use of plant stress-protectors has taken on particular significance due to the wide distribution of neurosis-like and neurotic diseases caused by neuroendocrine-immune system imbalance. Special attention has been paid to the plants containing ecdysteroids, i.e., hormone-like bioactive substances with high adaptogenic activity. The article deals with the study of bioactivity of two plant extracts as <i>Rhaponticum uniflorum</i> (L.) DC. and <i>Serratula centauroides</i> L. with a high content of ecdysteroids and phenolic compounds. The models of acute and chronic emotional stress in white rats were used to estimate the stress-protective activity of <i>R. uniflorum</i> and <i>S. centauroides</i> extracts. Both extracts showed the stress-protective effect via inhibiting the development of signs induced by single and long-term effects of stress factors. In acute stress, the development of Selye's triad signs was less pronounced against the background of the plant remedies introduction. In chronic stress, the extracts prevented the development of anxiety-depressive syndrome. Besides, <i>R. uniflorum</i> and <i>S. centauroides</i> extracts banned the development of stress-induced injuries in the brain cortex and had a neuroprotective effect on ischemia against chronic stress. The stress-protective effects of both plant extracts were based on a decrease of hyperactivation of the central stress-promoting systems (sympathoadrenal, hypothalamic-pituitary-adrenal) due to their GABA-mimetic effects. Peripheral mechanisms were connected with the inhibition of free radical oxidation processes and with an increase in the endogenous antioxidant system activity. Thus, <i>R. uniflorum</i> and <i>S. centauroides</i> extracts have a high potential to increase non-specific body resistance against acute and chronic emotional stress effects.Larisa N. ShantanovaDaniil N. OlennikovIrinchey E. MatkhanovSergey M. GulyaevAnyuta A. ToropovaIrina G. NikolaevaSergey M. NikolaevMDPI AGarticle<i>Rhaponticum uniflorum</i><i>Serratula centauroides</i>ecdysteroidscaffeoylquinic acidsemotional stressdepressionMedicineRPharmacy and materia medicaRS1-441ENPharmaceuticals, Vol 14, Iss 1186, p 1186 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Rhaponticum uniflorum</i> <i>Serratula centauroides</i> ecdysteroids caffeoylquinic acids emotional stress depression Medicine R Pharmacy and materia medica RS1-441
spellingShingle	<i>Rhaponticum uniflorum</i> <i>Serratula centauroides</i> ecdysteroids caffeoylquinic acids emotional stress depression Medicine R Pharmacy and materia medica RS1-441 Larisa N. Shantanova Daniil N. Olennikov Irinchey E. Matkhanov Sergey M. Gulyaev Anyuta A. Toropova Irina G. Nikolaeva Sergey M. Nikolaev <i>Rhaponticum uniflorum</i> and <i>Serratula centauroides</i> Extracts Attenuate Emotional Injury in Acute and Chronic Emotional Stress
description	In modern life, the use of plant stress-protectors has taken on particular significance due to the wide distribution of neurosis-like and neurotic diseases caused by neuroendocrine-immune system imbalance. Special attention has been paid to the plants containing ecdysteroids, i.e., hormone-like bioactive substances with high adaptogenic activity. The article deals with the study of bioactivity of two plant extracts as <i>Rhaponticum uniflorum</i> (L.) DC. and <i>Serratula centauroides</i> L. with a high content of ecdysteroids and phenolic compounds. The models of acute and chronic emotional stress in white rats were used to estimate the stress-protective activity of <i>R. uniflorum</i> and <i>S. centauroides</i> extracts. Both extracts showed the stress-protective effect via inhibiting the development of signs induced by single and long-term effects of stress factors. In acute stress, the development of Selye's triad signs was less pronounced against the background of the plant remedies introduction. In chronic stress, the extracts prevented the development of anxiety-depressive syndrome. Besides, <i>R. uniflorum</i> and <i>S. centauroides</i> extracts banned the development of stress-induced injuries in the brain cortex and had a neuroprotective effect on ischemia against chronic stress. The stress-protective effects of both plant extracts were based on a decrease of hyperactivation of the central stress-promoting systems (sympathoadrenal, hypothalamic-pituitary-adrenal) due to their GABA-mimetic effects. Peripheral mechanisms were connected with the inhibition of free radical oxidation processes and with an increase in the endogenous antioxidant system activity. Thus, <i>R. uniflorum</i> and <i>S. centauroides</i> extracts have a high potential to increase non-specific body resistance against acute and chronic emotional stress effects.
format	article
author	Larisa N. Shantanova Daniil N. Olennikov Irinchey E. Matkhanov Sergey M. Gulyaev Anyuta A. Toropova Irina G. Nikolaeva Sergey M. Nikolaev
author_facet	Larisa N. Shantanova Daniil N. Olennikov Irinchey E. Matkhanov Sergey M. Gulyaev Anyuta A. Toropova Irina G. Nikolaeva Sergey M. Nikolaev
author_sort	Larisa N. Shantanova
title	<i>Rhaponticum uniflorum</i> and <i>Serratula centauroides</i> Extracts Attenuate Emotional Injury in Acute and Chronic Emotional Stress
title_short	<i>Rhaponticum uniflorum</i> and <i>Serratula centauroides</i> Extracts Attenuate Emotional Injury in Acute and Chronic Emotional Stress
title_full	<i>Rhaponticum uniflorum</i> and <i>Serratula centauroides</i> Extracts Attenuate Emotional Injury in Acute and Chronic Emotional Stress
title_fullStr	<i>Rhaponticum uniflorum</i> and <i>Serratula centauroides</i> Extracts Attenuate Emotional Injury in Acute and Chronic Emotional Stress
title_full_unstemmed	<i>Rhaponticum uniflorum</i> and <i>Serratula centauroides</i> Extracts Attenuate Emotional Injury in Acute and Chronic Emotional Stress
title_sort	<i>rhaponticum uniflorum</i> and <i>serratula centauroides</i> extracts attenuate emotional injury in acute and chronic emotional stress
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/45b5ea7220774a3e8069265c5340ed33
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<i>Rhaponticum uniflorum</i> and <i>Serratula centauroides</i> Extracts Attenuate Emotional Injury in Acute and Chronic Emotional Stress

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