Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex

Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex

The tripartite multidrug efflux system MexAB-OprM is a major actor in Pseudomonas aeruginosa antibiotic resistance by exporting a large variety of antimicrobial compounds. Here authors present cryo-EM structures of MexB at various stages of the assembly process and provide evidence that MexB activat...

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Autores principales: Marie Glavier, Dhenesh Puvanendran, Dimitri Salvador, Marion Decossas, Gilles Phan, Cyril Garnier, Elisa Frezza, Quentin Cece, Guy Schoehn, Martin Picard, Jean-Christophe Taveau, Laetitia Daury, Isabelle Broutin, Olivier Lambert
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/45b848677d664bb2a4cbada3e29d4ee0
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spelling oai:doaj.org-article:45b848677d664bb2a4cbada3e29d4ee02021-12-02T19:17:00ZAntibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex10.1038/s41467-020-18770-52041-1723https://doaj.org/article/45b848677d664bb2a4cbada3e29d4ee02020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18770-5https://doaj.org/toc/2041-1723The tripartite multidrug efflux system MexAB-OprM is a major actor in Pseudomonas aeruginosa antibiotic resistance by exporting a large variety of antimicrobial compounds. Here authors present cryo-EM structures of MexB at various stages of the assembly process and provide evidence that MexB activation is mediated by OprM and MexA.Marie GlavierDhenesh PuvanendranDimitri SalvadorMarion DecossasGilles PhanCyril GarnierElisa FrezzaQuentin CeceGuy SchoehnMartin PicardJean-Christophe TaveauLaetitia DauryIsabelle BroutinOlivier LambertNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Marie Glavier
Dhenesh Puvanendran
Dimitri Salvador
Marion Decossas
Gilles Phan
Cyril Garnier
Elisa Frezza
Quentin Cece
Guy Schoehn
Martin Picard
Jean-Christophe Taveau
Laetitia Daury
Isabelle Broutin
Olivier Lambert
Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex
description The tripartite multidrug efflux system MexAB-OprM is a major actor in Pseudomonas aeruginosa antibiotic resistance by exporting a large variety of antimicrobial compounds. Here authors present cryo-EM structures of MexB at various stages of the assembly process and provide evidence that MexB activation is mediated by OprM and MexA.
format article
author Marie Glavier
Dhenesh Puvanendran
Dimitri Salvador
Marion Decossas
Gilles Phan
Cyril Garnier
Elisa Frezza
Quentin Cece
Guy Schoehn
Martin Picard
Jean-Christophe Taveau
Laetitia Daury
Isabelle Broutin
Olivier Lambert
author_facet Marie Glavier
Dhenesh Puvanendran
Dimitri Salvador
Marion Decossas
Gilles Phan
Cyril Garnier
Elisa Frezza
Quentin Cece
Guy Schoehn
Martin Picard
Jean-Christophe Taveau
Laetitia Daury
Isabelle Broutin
Olivier Lambert
author_sort Marie Glavier
title Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex
title_short Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex
title_full Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex
title_fullStr Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex
title_full_unstemmed Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex
title_sort antibiotic export by mexb multidrug efflux transporter is allosterically controlled by a mexa-oprm chaperone-like complex
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/45b848677d664bb2a4cbada3e29d4ee0
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