Clinical features and factors associated with outcomes of patients infected with a Novel Influenza A (H7N9) virus: a preliminary study.

<h4>Objective</h4>The present study aimed to analyze clinical features and factors associated with treatment outcomes of H7N9 influenza A virus infection.<h4>Methods</h4>The clinical progress in 18 H7N9-infected patients was monitored and recorded. The clinical features of H7...

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Autores principales:	Xiaorong Chen, Zongguo Yang, Yunfei Lu, Qingnian Xu, Qiang Wang, Liang Chen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/45b98f79cb854a97be58068bd07e554b
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spelling	oai:doaj.org-article:45b98f79cb854a97be58068bd07e554b2021-11-18T08:54:58ZClinical features and factors associated with outcomes of patients infected with a Novel Influenza A (H7N9) virus: a preliminary study.1932-620310.1371/journal.pone.0073362https://doaj.org/article/45b98f79cb854a97be58068bd07e554b2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24069191/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>The present study aimed to analyze clinical features and factors associated with treatment outcomes of H7N9 influenza A virus infection.<h4>Methods</h4>The clinical progress in 18 H7N9-infected patients was monitored and recorded. The clinical features of H7N9 infection were noted and factors associated with treatment outcomes were analyzed by univariate analyses.<h4>Results</h4>The average ages of patients in recovered and critical conditions were 67.0±10.83 years and 72.75±12.0 years, respectively. Renal insufficiency developed more frequently in critically ill patients (P = 0.023). The duration of traditional Chinese medicine (TCM) therapy was longer in recovered patients than in critically ill patients (P = 0.01). Laboratory tests showed that levels of C-reactive protein, serum creatinine, and myoglobin were significantly higher in critically ill patients than in recovered patients (P = 0.011, 0.04, and 0.016, respectively). Meanwhile, levels of all T cell subsets examined including total CD3(+), CD4(+), CD8(+), and CD45(+) T cells were lower in critically ill patients than in recovered patients (P = 0.033, 0.059, 0.015, and 0.039, respectively). Logistic regression analysis demonstrated that C-reactive protein level, myoglobin level and TCM therapy duration were likely associated with treatment outcomes of H7N9 infection (P = 0.032, 0.041 and 0.017, respectively).<h4>Conclusion</h4>Elderly people may have increased risk for H7N9 virus infection. T cell-mediated responses play an important role in defense against the H7N9 virus. C-reactive protein level, myoglobin level and TCM duration may be associated with treatment outcomes of H7N9 infection.Xiaorong ChenZongguo YangYunfei LuQingnian XuQiang WangLiang ChenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e73362 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaorong Chen Zongguo Yang Yunfei Lu Qingnian Xu Qiang Wang Liang Chen Clinical features and factors associated with outcomes of patients infected with a Novel Influenza A (H7N9) virus: a preliminary study.
description	<h4>Objective</h4>The present study aimed to analyze clinical features and factors associated with treatment outcomes of H7N9 influenza A virus infection.<h4>Methods</h4>The clinical progress in 18 H7N9-infected patients was monitored and recorded. The clinical features of H7N9 infection were noted and factors associated with treatment outcomes were analyzed by univariate analyses.<h4>Results</h4>The average ages of patients in recovered and critical conditions were 67.0±10.83 years and 72.75±12.0 years, respectively. Renal insufficiency developed more frequently in critically ill patients (P = 0.023). The duration of traditional Chinese medicine (TCM) therapy was longer in recovered patients than in critically ill patients (P = 0.01). Laboratory tests showed that levels of C-reactive protein, serum creatinine, and myoglobin were significantly higher in critically ill patients than in recovered patients (P = 0.011, 0.04, and 0.016, respectively). Meanwhile, levels of all T cell subsets examined including total CD3(+), CD4(+), CD8(+), and CD45(+) T cells were lower in critically ill patients than in recovered patients (P = 0.033, 0.059, 0.015, and 0.039, respectively). Logistic regression analysis demonstrated that C-reactive protein level, myoglobin level and TCM therapy duration were likely associated with treatment outcomes of H7N9 infection (P = 0.032, 0.041 and 0.017, respectively).<h4>Conclusion</h4>Elderly people may have increased risk for H7N9 virus infection. T cell-mediated responses play an important role in defense against the H7N9 virus. C-reactive protein level, myoglobin level and TCM duration may be associated with treatment outcomes of H7N9 infection.
format	article
author	Xiaorong Chen Zongguo Yang Yunfei Lu Qingnian Xu Qiang Wang Liang Chen
author_facet	Xiaorong Chen Zongguo Yang Yunfei Lu Qingnian Xu Qiang Wang Liang Chen
author_sort	Xiaorong Chen
title	Clinical features and factors associated with outcomes of patients infected with a Novel Influenza A (H7N9) virus: a preliminary study.
title_short	Clinical features and factors associated with outcomes of patients infected with a Novel Influenza A (H7N9) virus: a preliminary study.
title_full	Clinical features and factors associated with outcomes of patients infected with a Novel Influenza A (H7N9) virus: a preliminary study.
title_fullStr	Clinical features and factors associated with outcomes of patients infected with a Novel Influenza A (H7N9) virus: a preliminary study.
title_full_unstemmed	Clinical features and factors associated with outcomes of patients infected with a Novel Influenza A (H7N9) virus: a preliminary study.
title_sort	clinical features and factors associated with outcomes of patients infected with a novel influenza a (h7n9) virus: a preliminary study.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/45b98f79cb854a97be58068bd07e554b
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Clinical features and factors associated with outcomes of patients infected with a Novel Influenza A (H7N9) virus: a preliminary study.

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