Multivalent contacts of the Hsp70 Ssb contribute to its architecture on ribosomes and nascent chain interaction

The correct folding of proteins often requires the intervention molecular chaperones, which can occur co-translationally. Here the authors identify elements of yeast Ssb (Hsp70) that mediate ribosomal binding, and suggest a mechanism that directs efficient interaction of Ssb with the nascent chain.

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Autores principales:	Marie A. Hanebuth, Roman Kityk, Sandra J. Fries, Alok Jain, Allison Kriel, Veronique Albanese, Tancred Frickey, Christine Peter, Matthias P. Mayer, Judith Frydman, Elke Deuerling
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/45bf1ec4fc9046fa86502a2fa61438d3
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spelling	oai:doaj.org-article:45bf1ec4fc9046fa86502a2fa61438d32021-12-02T14:39:34ZMultivalent contacts of the Hsp70 Ssb contribute to its architecture on ribosomes and nascent chain interaction10.1038/ncomms136952041-1723https://doaj.org/article/45bf1ec4fc9046fa86502a2fa61438d32016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13695https://doaj.org/toc/2041-1723The correct folding of proteins often requires the intervention molecular chaperones, which can occur co-translationally. Here the authors identify elements of yeast Ssb (Hsp70) that mediate ribosomal binding, and suggest a mechanism that directs efficient interaction of Ssb with the nascent chain.Marie A. HanebuthRoman KitykSandra J. FriesAlok JainAllison KrielVeronique AlbaneseTancred FrickeyChristine PeterMatthias P. MayerJudith FrydmanElke DeuerlingNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marie A. Hanebuth Roman Kityk Sandra J. Fries Alok Jain Allison Kriel Veronique Albanese Tancred Frickey Christine Peter Matthias P. Mayer Judith Frydman Elke Deuerling Multivalent contacts of the Hsp70 Ssb contribute to its architecture on ribosomes and nascent chain interaction
description	The correct folding of proteins often requires the intervention molecular chaperones, which can occur co-translationally. Here the authors identify elements of yeast Ssb (Hsp70) that mediate ribosomal binding, and suggest a mechanism that directs efficient interaction of Ssb with the nascent chain.
format	article
author	Marie A. Hanebuth Roman Kityk Sandra J. Fries Alok Jain Allison Kriel Veronique Albanese Tancred Frickey Christine Peter Matthias P. Mayer Judith Frydman Elke Deuerling
author_facet	Marie A. Hanebuth Roman Kityk Sandra J. Fries Alok Jain Allison Kriel Veronique Albanese Tancred Frickey Christine Peter Matthias P. Mayer Judith Frydman Elke Deuerling
author_sort	Marie A. Hanebuth
title	Multivalent contacts of the Hsp70 Ssb contribute to its architecture on ribosomes and nascent chain interaction
title_short	Multivalent contacts of the Hsp70 Ssb contribute to its architecture on ribosomes and nascent chain interaction
title_full	Multivalent contacts of the Hsp70 Ssb contribute to its architecture on ribosomes and nascent chain interaction
title_fullStr	Multivalent contacts of the Hsp70 Ssb contribute to its architecture on ribosomes and nascent chain interaction
title_full_unstemmed	Multivalent contacts of the Hsp70 Ssb contribute to its architecture on ribosomes and nascent chain interaction
title_sort	multivalent contacts of the hsp70 ssb contribute to its architecture on ribosomes and nascent chain interaction
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/45bf1ec4fc9046fa86502a2fa61438d3
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Multivalent contacts of the Hsp70 Ssb contribute to its architecture on ribosomes and nascent chain interaction

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