Activation of IL-8 and its participation in cancer in schizophrenia patients: new evidence for the autoimmune hypothesis of schizophrenia

Lvzi Xu,1 Xiao Qi,2 Chi Zhu,3 Lihua Wan1 1Department of Forensic Medicine, Chongqing Medical University, Chongqing, China; 2Department of Rehabilitation, Xinqiao Hospital, Third Military Medical University, Chongqing, China; 3Department of Neurology, Center for Clinical Neuroscience, Daping Hospita...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xu LZ, Qi X, Zhu C, Wan LH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Schizophrenia Cancer Autoimmune disease IL8 GSEA Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/45c3f1b945a14480af852997741d39b3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:45c3f1b945a14480af852997741d39b3
record_format	dspace
spelling	oai:doaj.org-article:45c3f1b945a14480af852997741d39b32021-12-02T07:59:44ZActivation of IL-8 and its participation in cancer in schizophrenia patients: new evidence for the autoimmune hypothesis of schizophrenia1178-2021https://doaj.org/article/45c3f1b945a14480af852997741d39b32018-12-01T00:00:00Zhttps://www.dovepress.com/activation-of-il-8-and-its-participation-in-cancer-in-schizophrenia-pa-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Lvzi Xu,1 Xiao Qi,2 Chi Zhu,3 Lihua Wan1 1Department of Forensic Medicine, Chongqing Medical University, Chongqing, China; 2Department of Rehabilitation, Xinqiao Hospital, Third Military Medical University, Chongqing, China; 3Department of Neurology, Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China Abstract: To investigate the autoimmune mechanisms of schizophrenia, we explored the relationship between schizophrenia and cancer using gene expression data of peripheral blood mononuclear cells from GSE27383 datasets. Gene screening and enrichment analysis using Gene Set Enrichment Analysis were applied to identify possible connections between schizophrenia and cancer. Real-time PCR (quantitative PCR), Western blotting and immunohistochemistry were performed on the brain tissue from both schizophrenia patients and normal controls. The genes for IL-8, as well as PTGS2, TPR, JUN, CXCL1, CXCL3, CXCL5 and PARD3 were highly expressed in schizophrenia patients. Cancer and chemokine signaling pathways were enriched in the schizophrenic group, related to the high expression of IL-8. Increased expression of IL-8 was further confirmed by quantitative PCR, Western blotting and immunohistochemistry results. Our results suggest that IL-8 may participate specifically in the pathophysiological changes that occur in schizophrenia. Additionally, our findings provide novel evidence supporting the autoimmune hypothesis of schizophrenia. Keywords: bioinformatics, multiple primary cancers, autoimmune disease, cancer pathway, GSEAXu LZQi XZhu CWan LHDove Medical PressarticleSchizophreniaCancerAutoimmune diseaseIL8GSEANeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 3393-3403 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Schizophrenia Cancer Autoimmune disease IL8 GSEA Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Schizophrenia Cancer Autoimmune disease IL8 GSEA Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Xu LZ Qi X Zhu C Wan LH Activation of IL-8 and its participation in cancer in schizophrenia patients: new evidence for the autoimmune hypothesis of schizophrenia
description	Lvzi Xu,1 Xiao Qi,2 Chi Zhu,3 Lihua Wan1 1Department of Forensic Medicine, Chongqing Medical University, Chongqing, China; 2Department of Rehabilitation, Xinqiao Hospital, Third Military Medical University, Chongqing, China; 3Department of Neurology, Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China Abstract: To investigate the autoimmune mechanisms of schizophrenia, we explored the relationship between schizophrenia and cancer using gene expression data of peripheral blood mononuclear cells from GSE27383 datasets. Gene screening and enrichment analysis using Gene Set Enrichment Analysis were applied to identify possible connections between schizophrenia and cancer. Real-time PCR (quantitative PCR), Western blotting and immunohistochemistry were performed on the brain tissue from both schizophrenia patients and normal controls. The genes for IL-8, as well as PTGS2, TPR, JUN, CXCL1, CXCL3, CXCL5 and PARD3 were highly expressed in schizophrenia patients. Cancer and chemokine signaling pathways were enriched in the schizophrenic group, related to the high expression of IL-8. Increased expression of IL-8 was further confirmed by quantitative PCR, Western blotting and immunohistochemistry results. Our results suggest that IL-8 may participate specifically in the pathophysiological changes that occur in schizophrenia. Additionally, our findings provide novel evidence supporting the autoimmune hypothesis of schizophrenia. Keywords: bioinformatics, multiple primary cancers, autoimmune disease, cancer pathway, GSEA
format	article
author	Xu LZ Qi X Zhu C Wan LH
author_facet	Xu LZ Qi X Zhu C Wan LH
author_sort	Xu LZ
title	Activation of IL-8 and its participation in cancer in schizophrenia patients: new evidence for the autoimmune hypothesis of schizophrenia
title_short	Activation of IL-8 and its participation in cancer in schizophrenia patients: new evidence for the autoimmune hypothesis of schizophrenia
title_full	Activation of IL-8 and its participation in cancer in schizophrenia patients: new evidence for the autoimmune hypothesis of schizophrenia
title_fullStr	Activation of IL-8 and its participation in cancer in schizophrenia patients: new evidence for the autoimmune hypothesis of schizophrenia
title_full_unstemmed	Activation of IL-8 and its participation in cancer in schizophrenia patients: new evidence for the autoimmune hypothesis of schizophrenia
title_sort	activation of il-8 and its participation in cancer in schizophrenia patients: new evidence for the autoimmune hypothesis of schizophrenia
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/45c3f1b945a14480af852997741d39b3
work_keys_str_mv	AT xulz activationofil8anditsparticipationincancerinschizophreniapatientsnewevidencefortheautoimmunehypothesisofschizophrenia AT qix activationofil8anditsparticipationincancerinschizophreniapatientsnewevidencefortheautoimmunehypothesisofschizophrenia AT zhuc activationofil8anditsparticipationincancerinschizophreniapatientsnewevidencefortheautoimmunehypothesisofschizophrenia AT wanlh activationofil8anditsparticipationincancerinschizophreniapatientsnewevidencefortheautoimmunehypothesisofschizophrenia
_version_	1718398719193251840

Activation of IL-8 and its participation in cancer in schizophrenia patients: new evidence for the autoimmune hypothesis of schizophrenia

Ejemplares similares