FALSE SUGAR SEQUENCE PHENOMENON AND STRUCTURAL ANALYSIS OF α-HEDERIN AND HEDERACOSIDE C THROUGH ELECTROSPRAY IONIZATION AND MULTI-STAGE TANDEM MASS SPECTROMETRY

Saponins are glycosides regularly found in plants, and they are frequently analyzed by means of electrospray ion sources and tandem mass spectrometry (ESI/MSn), not only to obtain an overall molecular weight through the high sensitivity of mass spectrometry, but also to obtain their structural infor...

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Autores principales:	Guillermo MONTOYA, Nora JIMÉNEZ
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2011
Materias:	pérdida de azúcar interno saponinas triterpénicas electrospray sistema de ionización espectrometría de masas Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/45c96b9abf01442e97a8c46797cab29e
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spelling	oai:doaj.org-article:45c96b9abf01442e97a8c46797cab29e2021-12-02T10:56:04ZFALSE SUGAR SEQUENCE PHENOMENON AND STRUCTURAL ANALYSIS OF α-HEDERIN AND HEDERACOSIDE C THROUGH ELECTROSPRAY IONIZATION AND MULTI-STAGE TANDEM MASS SPECTROMETRY0121-4004https://doaj.org/article/45c96b9abf01442e97a8c46797cab29e2011-09-01T00:00:00Zhttp://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0121-40042011000300010&lng=en&tlng=enhttps://doaj.org/toc/0121-4004Saponins are glycosides regularly found in plants, and they are frequently analyzed by means of electrospray ion sources and tandem mass spectrometry (ESI/MSn), not only to obtain an overall molecular weight through the high sensitivity of mass spectrometry, but also to obtain their structural information. The use of modern analytic techniques (such as ESI/MSn) aids the discovery and quality control assessment of new molecules found in botanicals; however, some rearrangements have been described for oligosaccharides that produce an incorrect elucidation of the molecules. For the first time, evidence for an internal sugar loss on the protonated fragmentation of α-hederin has been reported. This phenomenon can be avoided by using alkali metal ion adducts, such as lithium and sodium cations, to confirm the real sugar sequence when a structural identification is performed. In this study, the structural characterization of α-hederin and hederacoside C is conducted by comparing positive and negative modes. Different fragmentation patterns occur, and such patterns are useful in the structural analysis of saponins when they are present on different matrixes.Guillermo MONTOYANora JIMÉNEZUniversidad de Antioquiaarticlepérdida de azúcar internosaponinas triterpénicaselectrospraysistema de ionizaciónespectrometría de masasFood processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 18, Iss 3, Pp 312-318 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	pérdida de azúcar interno saponinas triterpénicas electrospray sistema de ionización espectrometría de masas Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	pérdida de azúcar interno saponinas triterpénicas electrospray sistema de ionización espectrometría de masas Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Guillermo MONTOYA Nora JIMÉNEZ FALSE SUGAR SEQUENCE PHENOMENON AND STRUCTURAL ANALYSIS OF α-HEDERIN AND HEDERACOSIDE C THROUGH ELECTROSPRAY IONIZATION AND MULTI-STAGE TANDEM MASS SPECTROMETRY
description	Saponins are glycosides regularly found in plants, and they are frequently analyzed by means of electrospray ion sources and tandem mass spectrometry (ESI/MSn), not only to obtain an overall molecular weight through the high sensitivity of mass spectrometry, but also to obtain their structural information. The use of modern analytic techniques (such as ESI/MSn) aids the discovery and quality control assessment of new molecules found in botanicals; however, some rearrangements have been described for oligosaccharides that produce an incorrect elucidation of the molecules. For the first time, evidence for an internal sugar loss on the protonated fragmentation of α-hederin has been reported. This phenomenon can be avoided by using alkali metal ion adducts, such as lithium and sodium cations, to confirm the real sugar sequence when a structural identification is performed. In this study, the structural characterization of α-hederin and hederacoside C is conducted by comparing positive and negative modes. Different fragmentation patterns occur, and such patterns are useful in the structural analysis of saponins when they are present on different matrixes.
format	article
author	Guillermo MONTOYA Nora JIMÉNEZ
author_facet	Guillermo MONTOYA Nora JIMÉNEZ
author_sort	Guillermo MONTOYA
title	FALSE SUGAR SEQUENCE PHENOMENON AND STRUCTURAL ANALYSIS OF α-HEDERIN AND HEDERACOSIDE C THROUGH ELECTROSPRAY IONIZATION AND MULTI-STAGE TANDEM MASS SPECTROMETRY
title_short	FALSE SUGAR SEQUENCE PHENOMENON AND STRUCTURAL ANALYSIS OF α-HEDERIN AND HEDERACOSIDE C THROUGH ELECTROSPRAY IONIZATION AND MULTI-STAGE TANDEM MASS SPECTROMETRY
title_full	FALSE SUGAR SEQUENCE PHENOMENON AND STRUCTURAL ANALYSIS OF α-HEDERIN AND HEDERACOSIDE C THROUGH ELECTROSPRAY IONIZATION AND MULTI-STAGE TANDEM MASS SPECTROMETRY
title_fullStr	FALSE SUGAR SEQUENCE PHENOMENON AND STRUCTURAL ANALYSIS OF α-HEDERIN AND HEDERACOSIDE C THROUGH ELECTROSPRAY IONIZATION AND MULTI-STAGE TANDEM MASS SPECTROMETRY
title_full_unstemmed	FALSE SUGAR SEQUENCE PHENOMENON AND STRUCTURAL ANALYSIS OF α-HEDERIN AND HEDERACOSIDE C THROUGH ELECTROSPRAY IONIZATION AND MULTI-STAGE TANDEM MASS SPECTROMETRY
title_sort	false sugar sequence phenomenon and structural analysis of α-hederin and hederacoside c through electrospray ionization and multi-stage tandem mass spectrometry
publisher	Universidad de Antioquia
publishDate	2011
url	https://doaj.org/article/45c96b9abf01442e97a8c46797cab29e
work_keys_str_mv	AT guillermomontoya falsesugarsequencephenomenonandstructuralanalysisofahederinandhederacosidecthroughelectrosprayionizationandmultistagetandemmassspectrometry AT norajimenez falsesugarsequencephenomenonandstructuralanalysisofahederinandhederacosidecthroughelectrosprayionizationandmultistagetandemmassspectrometry
_version_	1718396398823538688

FALSE SUGAR SEQUENCE PHENOMENON AND STRUCTURAL ANALYSIS OF α-HEDERIN AND HEDERACOSIDE C THROUGH ELECTROSPRAY IONIZATION AND MULTI-STAGE TANDEM MASS SPECTROMETRY

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