Combined Angiotensin II Type-1 Receptor Blockade and Superoxide Anion Scavenging Affect the Post-Ischemic Kidney in Hypertensive Rats

Ischemic acute kidney injury is characterized by renal vasoconstriction, filtration failure, tubular obstruction, tubular backleak and overproduction of angiotensin II and reactive oxygen species. Considering this complexity, the aim of our study was to investigate the effects of angiotensin II type...

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Autores principales: Ivanov Milan, Mihailović-Stanojević Nevena, Marković-Lipkovski Jasmina, Jovović Đurđica, Karanović Danijela, Miloradović Zoran, Grujić-Milanović Jelica
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Publicado: Sciendo 2016
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Acceso en línea:https://doaj.org/article/45c96f923889471dac8611a931ed0296
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spelling oai:doaj.org-article:45c96f923889471dac8611a931ed02962021-11-17T21:27:51ZCombined Angiotensin II Type-1 Receptor Blockade and Superoxide Anion Scavenging Affect the Post-Ischemic Kidney in Hypertensive Rats1820-744810.1515/acve-2016-0033https://doaj.org/article/45c96f923889471dac8611a931ed02962016-09-01T00:00:00Zhttps://doi.org/10.1515/acve-2016-0033https://doaj.org/toc/1820-7448Ischemic acute kidney injury is characterized by renal vasoconstriction, filtration failure, tubular obstruction, tubular backleak and overproduction of angiotensin II and reactive oxygen species. Considering this complexity, the aim of our study was to investigate the effects of angiotensin II type-1 receptor blocker - Losartan and superoxide anion scavenger - Tempol, in a combined treatment on acute kidney injury in postischemic hypertensive rats.Ivanov MilanMihailović-Stanojević NevenaMarković-Lipkovski JasminaJovović ĐurđicaKaranović DanijelaMiloradović ZoranGrujić-Milanović JelicaSciendoarticleacute kidney injuryhypertensionlosartanreactive oxygen speciestempolVeterinary medicineSF600-1100ENActa Veterinaria, Vol 66, Iss 3, Pp 392-405 (2016)
institution DOAJ
collection DOAJ
language EN
topic acute kidney injury
hypertension
losartan
reactive oxygen species
tempol
Veterinary medicine
SF600-1100
spellingShingle acute kidney injury
hypertension
losartan
reactive oxygen species
tempol
Veterinary medicine
SF600-1100
Ivanov Milan
Mihailović-Stanojević Nevena
Marković-Lipkovski Jasmina
Jovović Đurđica
Karanović Danijela
Miloradović Zoran
Grujić-Milanović Jelica
Combined Angiotensin II Type-1 Receptor Blockade and Superoxide Anion Scavenging Affect the Post-Ischemic Kidney in Hypertensive Rats
description Ischemic acute kidney injury is characterized by renal vasoconstriction, filtration failure, tubular obstruction, tubular backleak and overproduction of angiotensin II and reactive oxygen species. Considering this complexity, the aim of our study was to investigate the effects of angiotensin II type-1 receptor blocker - Losartan and superoxide anion scavenger - Tempol, in a combined treatment on acute kidney injury in postischemic hypertensive rats.
format article
author Ivanov Milan
Mihailović-Stanojević Nevena
Marković-Lipkovski Jasmina
Jovović Đurđica
Karanović Danijela
Miloradović Zoran
Grujić-Milanović Jelica
author_facet Ivanov Milan
Mihailović-Stanojević Nevena
Marković-Lipkovski Jasmina
Jovović Đurđica
Karanović Danijela
Miloradović Zoran
Grujić-Milanović Jelica
author_sort Ivanov Milan
title Combined Angiotensin II Type-1 Receptor Blockade and Superoxide Anion Scavenging Affect the Post-Ischemic Kidney in Hypertensive Rats
title_short Combined Angiotensin II Type-1 Receptor Blockade and Superoxide Anion Scavenging Affect the Post-Ischemic Kidney in Hypertensive Rats
title_full Combined Angiotensin II Type-1 Receptor Blockade and Superoxide Anion Scavenging Affect the Post-Ischemic Kidney in Hypertensive Rats
title_fullStr Combined Angiotensin II Type-1 Receptor Blockade and Superoxide Anion Scavenging Affect the Post-Ischemic Kidney in Hypertensive Rats
title_full_unstemmed Combined Angiotensin II Type-1 Receptor Blockade and Superoxide Anion Scavenging Affect the Post-Ischemic Kidney in Hypertensive Rats
title_sort combined angiotensin ii type-1 receptor blockade and superoxide anion scavenging affect the post-ischemic kidney in hypertensive rats
publisher Sciendo
publishDate 2016
url https://doaj.org/article/45c96f923889471dac8611a931ed0296
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