Combined Angiotensin II Type-1 Receptor Blockade and Superoxide Anion Scavenging Affect the Post-Ischemic Kidney in Hypertensive Rats
Ischemic acute kidney injury is characterized by renal vasoconstriction, filtration failure, tubular obstruction, tubular backleak and overproduction of angiotensin II and reactive oxygen species. Considering this complexity, the aim of our study was to investigate the effects of angiotensin II type...
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oai:doaj.org-article:45c96f923889471dac8611a931ed02962021-11-17T21:27:51ZCombined Angiotensin II Type-1 Receptor Blockade and Superoxide Anion Scavenging Affect the Post-Ischemic Kidney in Hypertensive Rats1820-744810.1515/acve-2016-0033https://doaj.org/article/45c96f923889471dac8611a931ed02962016-09-01T00:00:00Zhttps://doi.org/10.1515/acve-2016-0033https://doaj.org/toc/1820-7448Ischemic acute kidney injury is characterized by renal vasoconstriction, filtration failure, tubular obstruction, tubular backleak and overproduction of angiotensin II and reactive oxygen species. Considering this complexity, the aim of our study was to investigate the effects of angiotensin II type-1 receptor blocker - Losartan and superoxide anion scavenger - Tempol, in a combined treatment on acute kidney injury in postischemic hypertensive rats.Ivanov MilanMihailović-Stanojević NevenaMarković-Lipkovski JasminaJovović ĐurđicaKaranović DanijelaMiloradović ZoranGrujić-Milanović JelicaSciendoarticleacute kidney injuryhypertensionlosartanreactive oxygen speciestempolVeterinary medicineSF600-1100ENActa Veterinaria, Vol 66, Iss 3, Pp 392-405 (2016) |
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DOAJ |
language |
EN |
topic |
acute kidney injury hypertension losartan reactive oxygen species tempol Veterinary medicine SF600-1100 |
spellingShingle |
acute kidney injury hypertension losartan reactive oxygen species tempol Veterinary medicine SF600-1100 Ivanov Milan Mihailović-Stanojević Nevena Marković-Lipkovski Jasmina Jovović Đurđica Karanović Danijela Miloradović Zoran Grujić-Milanović Jelica Combined Angiotensin II Type-1 Receptor Blockade and Superoxide Anion Scavenging Affect the Post-Ischemic Kidney in Hypertensive Rats |
description |
Ischemic acute kidney injury is characterized by renal vasoconstriction, filtration failure, tubular obstruction, tubular backleak and overproduction of angiotensin II and reactive oxygen species. Considering this complexity, the aim of our study was to investigate the effects of angiotensin II type-1 receptor blocker - Losartan and superoxide anion scavenger - Tempol, in a combined treatment on acute kidney injury in postischemic hypertensive rats. |
format |
article |
author |
Ivanov Milan Mihailović-Stanojević Nevena Marković-Lipkovski Jasmina Jovović Đurđica Karanović Danijela Miloradović Zoran Grujić-Milanović Jelica |
author_facet |
Ivanov Milan Mihailović-Stanojević Nevena Marković-Lipkovski Jasmina Jovović Đurđica Karanović Danijela Miloradović Zoran Grujić-Milanović Jelica |
author_sort |
Ivanov Milan |
title |
Combined Angiotensin II Type-1 Receptor Blockade and Superoxide Anion Scavenging Affect the Post-Ischemic Kidney in Hypertensive Rats |
title_short |
Combined Angiotensin II Type-1 Receptor Blockade and Superoxide Anion Scavenging Affect the Post-Ischemic Kidney in Hypertensive Rats |
title_full |
Combined Angiotensin II Type-1 Receptor Blockade and Superoxide Anion Scavenging Affect the Post-Ischemic Kidney in Hypertensive Rats |
title_fullStr |
Combined Angiotensin II Type-1 Receptor Blockade and Superoxide Anion Scavenging Affect the Post-Ischemic Kidney in Hypertensive Rats |
title_full_unstemmed |
Combined Angiotensin II Type-1 Receptor Blockade and Superoxide Anion Scavenging Affect the Post-Ischemic Kidney in Hypertensive Rats |
title_sort |
combined angiotensin ii type-1 receptor blockade and superoxide anion scavenging affect the post-ischemic kidney in hypertensive rats |
publisher |
Sciendo |
publishDate |
2016 |
url |
https://doaj.org/article/45c96f923889471dac8611a931ed0296 |
work_keys_str_mv |
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