Intracellular mGluR5 plays a critical role in neuropathic pain

mGluR5 has been shown to play a role in chronic pain regulation. Here, the authors use membrane permeable and non-transported, impermeable mGluR5 antagonists to show that spinal analgesic effects in vivoare mediated by intracellular rather than cell surface mGluR5.

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Detalles Bibliográficos
Autores principales:	Kathleen Vincent, Virginia M. Cornea, Yuh-Jiin I. Jong, André Laferrière, Naresh Kumar, Aiste Mickeviciute, Jollee S. T. Fung, Pouya Bandegi, Alfredo Ribeiro-da-Silva, Karen L. O’Malley, Terence J. Coderre
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/45ca321373524d27b5c7dedf94d4f290
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spelling	oai:doaj.org-article:45ca321373524d27b5c7dedf94d4f2902021-12-02T17:31:50ZIntracellular mGluR5 plays a critical role in neuropathic pain10.1038/ncomms106042041-1723https://doaj.org/article/45ca321373524d27b5c7dedf94d4f2902016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10604https://doaj.org/toc/2041-1723mGluR5 has been shown to play a role in chronic pain regulation. Here, the authors use membrane permeable and non-transported, impermeable mGluR5 antagonists to show that spinal analgesic effects in vivoare mediated by intracellular rather than cell surface mGluR5.Kathleen VincentVirginia M. CorneaYuh-Jiin I. JongAndré LaferrièreNaresh KumarAiste MickeviciuteJollee S. T. FungPouya BandegiAlfredo Ribeiro-da-SilvaKaren L. O’MalleyTerence J. CoderreNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kathleen Vincent Virginia M. Cornea Yuh-Jiin I. Jong André Laferrière Naresh Kumar Aiste Mickeviciute Jollee S. T. Fung Pouya Bandegi Alfredo Ribeiro-da-Silva Karen L. O’Malley Terence J. Coderre Intracellular mGluR5 plays a critical role in neuropathic pain
description	mGluR5 has been shown to play a role in chronic pain regulation. Here, the authors use membrane permeable and non-transported, impermeable mGluR5 antagonists to show that spinal analgesic effects in vivoare mediated by intracellular rather than cell surface mGluR5.
format	article
author	Kathleen Vincent Virginia M. Cornea Yuh-Jiin I. Jong André Laferrière Naresh Kumar Aiste Mickeviciute Jollee S. T. Fung Pouya Bandegi Alfredo Ribeiro-da-Silva Karen L. O’Malley Terence J. Coderre
author_facet	Kathleen Vincent Virginia M. Cornea Yuh-Jiin I. Jong André Laferrière Naresh Kumar Aiste Mickeviciute Jollee S. T. Fung Pouya Bandegi Alfredo Ribeiro-da-Silva Karen L. O’Malley Terence J. Coderre
author_sort	Kathleen Vincent
title	Intracellular mGluR5 plays a critical role in neuropathic pain
title_short	Intracellular mGluR5 plays a critical role in neuropathic pain
title_full	Intracellular mGluR5 plays a critical role in neuropathic pain
title_fullStr	Intracellular mGluR5 plays a critical role in neuropathic pain
title_full_unstemmed	Intracellular mGluR5 plays a critical role in neuropathic pain
title_sort	intracellular mglur5 plays a critical role in neuropathic pain
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/45ca321373524d27b5c7dedf94d4f290
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Intracellular mGluR5 plays a critical role in neuropathic pain

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