The autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour

The autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour

In humans, copy-number variants of the CYFIP1 gene have been associated with autism spectrum disorders and schizophrenia. Here, the authors characterize Cyfip1-heterozygous mice, revealing that they display deficits in brain white matter structure and functional connectivity along with abnormal beha...

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Autores principales: Nuria Domínguez-Iturza, Adrian C. Lo, Disha Shah, Marcelo Armendáriz, Anna Vannelli, Valentina Mercaldo, Massimo Trusel, Ka Wan Li, Denise Gastaldo, Ana Rita Santos, Zsuzsanna Callaerts-Vegh, Rudi D’Hooge, Manuel Mameli, Annemie Van der Linden, August B. Smit, Tilmann Achsel, Claudia Bagni
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/45ce8718dbe54af7bd35ef3ffe5acc3a
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Sumario:In humans, copy-number variants of the CYFIP1 gene have been associated with autism spectrum disorders and schizophrenia. Here, the authors characterize Cyfip1-heterozygous mice, revealing that they display deficits in brain white matter structure and functional connectivity along with abnormal behaviours.

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