The autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour

The autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour

In humans, copy-number variants of the CYFIP1 gene have been associated with autism spectrum disorders and schizophrenia. Here, the authors characterize Cyfip1-heterozygous mice, revealing that they display deficits in brain white matter structure and functional connectivity along with abnormal beha...

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Autores principales: Nuria Domínguez-Iturza, Adrian C. Lo, Disha Shah, Marcelo Armendáriz, Anna Vannelli, Valentina Mercaldo, Massimo Trusel, Ka Wan Li, Denise Gastaldo, Ana Rita Santos, Zsuzsanna Callaerts-Vegh, Rudi D’Hooge, Manuel Mameli, Annemie Van der Linden, August B. Smit, Tilmann Achsel, Claudia Bagni
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/45ce8718dbe54af7bd35ef3ffe5acc3a
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spelling oai:doaj.org-article:45ce8718dbe54af7bd35ef3ffe5acc3a2021-12-02T17:01:40ZThe autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour10.1038/s41467-019-11203-y2041-1723https://doaj.org/article/45ce8718dbe54af7bd35ef3ffe5acc3a2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11203-yhttps://doaj.org/toc/2041-1723In humans, copy-number variants of the CYFIP1 gene have been associated with autism spectrum disorders and schizophrenia. Here, the authors characterize Cyfip1-heterozygous mice, revealing that they display deficits in brain white matter structure and functional connectivity along with abnormal behaviours.Nuria Domínguez-IturzaAdrian C. LoDisha ShahMarcelo ArmendárizAnna VannelliValentina MercaldoMassimo TruselKa Wan LiDenise GastaldoAna Rita SantosZsuzsanna Callaerts-VeghRudi D’HoogeManuel MameliAnnemie Van der LindenAugust B. SmitTilmann AchselClaudia BagniNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Nuria Domínguez-Iturza
Adrian C. Lo
Disha Shah
Marcelo Armendáriz
Anna Vannelli
Valentina Mercaldo
Massimo Trusel
Ka Wan Li
Denise Gastaldo
Ana Rita Santos
Zsuzsanna Callaerts-Vegh
Rudi D’Hooge
Manuel Mameli
Annemie Van der Linden
August B. Smit
Tilmann Achsel
Claudia Bagni
The autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour
description In humans, copy-number variants of the CYFIP1 gene have been associated with autism spectrum disorders and schizophrenia. Here, the authors characterize Cyfip1-heterozygous mice, revealing that they display deficits in brain white matter structure and functional connectivity along with abnormal behaviours.
format article
author Nuria Domínguez-Iturza
Adrian C. Lo
Disha Shah
Marcelo Armendáriz
Anna Vannelli
Valentina Mercaldo
Massimo Trusel
Ka Wan Li
Denise Gastaldo
Ana Rita Santos
Zsuzsanna Callaerts-Vegh
Rudi D’Hooge
Manuel Mameli
Annemie Van der Linden
August B. Smit
Tilmann Achsel
Claudia Bagni
author_facet Nuria Domínguez-Iturza
Adrian C. Lo
Disha Shah
Marcelo Armendáriz
Anna Vannelli
Valentina Mercaldo
Massimo Trusel
Ka Wan Li
Denise Gastaldo
Ana Rita Santos
Zsuzsanna Callaerts-Vegh
Rudi D’Hooge
Manuel Mameli
Annemie Van der Linden
August B. Smit
Tilmann Achsel
Claudia Bagni
author_sort Nuria Domínguez-Iturza
title The autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour
title_short The autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour
title_full The autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour
title_fullStr The autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour
title_full_unstemmed The autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour
title_sort autism- and schizophrenia-associated protein cyfip1 regulates bilateral brain connectivity and behaviour
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/45ce8718dbe54af7bd35ef3ffe5acc3a
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