Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels
Vitamin D deficiency is associated with multiple human pathologic conditions. In a genome-wide association study of 79,366 individuals, Jiang et al. replicate four and identify two new genetic loci for serum levels of 25-hydroxyvitamin D and find evidence for a shared genetic basis with autoimmune d...
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Nature Portfolio
2018
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oai:doaj.org-article:45ceebb3cb0e4473b2cfdeb800d4099c2021-12-02T15:34:04ZGenome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels10.1038/s41467-017-02662-22041-1723https://doaj.org/article/45ceebb3cb0e4473b2cfdeb800d4099c2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02662-2https://doaj.org/toc/2041-1723Vitamin D deficiency is associated with multiple human pathologic conditions. In a genome-wide association study of 79,366 individuals, Jiang et al. replicate four and identify two new genetic loci for serum levels of 25-hydroxyvitamin D and find evidence for a shared genetic basis with autoimmune diseases.Xia JiangPaul F. O’ReillyHugues AschardYi-Hsiang HsuJ. Brent RichardsJosée DupuisErik IngelssonDavid KarasikStefan PilzDiane BerryBryan KestenbaumJusheng ZhengJianan LuanEleni SofianopoulouElizabeth A. StreetenDemetrius AlbanesPamela L. LutseyLu YaoWeihong TangMichael J. EconsHenri WallaschofskiHenry VölzkeAng ZhouChris PowerMark I. McCarthyErin D. MichosEric BoerwinkleStephanie J. WeinsteinNeal D. FreedmanWen-Yi HuangNatasja M. Van SchoorNathalie van der VeldeLisette C. P. G. M. de GrootAnke EnnemanL. Adrienne CupplesSarah L. BoothRamachandran S. VasanChing-Ti LiuYanhua ZhouSamuli RipattiClaes OhlssonLiesbeth VandenputMattias LorentzonJohan G. ErikssonM. Kyla SheaDenise K. HoustonStephen B. KritchevskyYongmei LiuKurt K. LohmanLuigi FerrucciMunro PeacockChristian GiegerMarian BeekmanEline SlagboomJoris DeelenDiana van HeemstMarcus E. KleberWinfried MärzIan H. de BoerAlexis C. WoodJerome I. RotterStephen S. RichCassianne Robinson-CohenMartin den HeijerMarjo-Riitta JarvelinAlana CavadinoPeter K. JoshiJames F. WilsonCaroline HaywardLars LindKarl MichaëlssonStella TrompetM. Carola ZillikensAndre G. UitterlindenFernando RivadeneiraLinda BroerLina ZgagaHarry CampbellEvropi TheodoratouSusan M. FarringtonMaria TimofeevaMalcolm G. DunlopAna M. ValdesEmmi TikkanenTerho LehtimäkiLeo-Pekka LyytikäinenMika KähönenOlli T. RaitakariVera MikkiläM. Arfan IkramNaveed SattarJ. Wouter JukemaNicholas J. WarehamClaudia LangenbergNita G. ForouhiThomas E. GundersenKay-Tee KhawAdam S. ButterworthJohn DaneshTimothy SpectorThomas J. WangElina HyppönenPeter KraftDouglas P. KielNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Xia Jiang Paul F. O’Reilly Hugues Aschard Yi-Hsiang Hsu J. Brent Richards Josée Dupuis Erik Ingelsson David Karasik Stefan Pilz Diane Berry Bryan Kestenbaum Jusheng Zheng Jianan Luan Eleni Sofianopoulou Elizabeth A. Streeten Demetrius Albanes Pamela L. Lutsey Lu Yao Weihong Tang Michael J. Econs Henri Wallaschofski Henry Völzke Ang Zhou Chris Power Mark I. McCarthy Erin D. Michos Eric Boerwinkle Stephanie J. Weinstein Neal D. Freedman Wen-Yi Huang Natasja M. Van Schoor Nathalie van der Velde Lisette C. P. G. M. de Groot Anke Enneman L. Adrienne Cupples Sarah L. Booth Ramachandran S. Vasan Ching-Ti Liu Yanhua Zhou Samuli Ripatti Claes Ohlsson Liesbeth Vandenput Mattias Lorentzon Johan G. Eriksson M. Kyla Shea Denise K. Houston Stephen B. Kritchevsky Yongmei Liu Kurt K. Lohman Luigi Ferrucci Munro Peacock Christian Gieger Marian Beekman Eline Slagboom Joris Deelen Diana van Heemst Marcus E. Kleber Winfried März Ian H. de Boer Alexis C. Wood Jerome I. Rotter Stephen S. Rich Cassianne Robinson-Cohen Martin den Heijer Marjo-Riitta Jarvelin Alana Cavadino Peter K. Joshi James F. Wilson Caroline Hayward Lars Lind Karl Michaëlsson Stella Trompet M. Carola Zillikens Andre G. Uitterlinden Fernando Rivadeneira Linda Broer Lina Zgaga Harry Campbell Evropi Theodoratou Susan M. Farrington Maria Timofeeva Malcolm G. Dunlop Ana M. Valdes Emmi Tikkanen Terho Lehtimäki Leo-Pekka Lyytikäinen Mika Kähönen Olli T. Raitakari Vera Mikkilä M. Arfan Ikram Naveed Sattar J. Wouter Jukema Nicholas J. Wareham Claudia Langenberg Nita G. Forouhi Thomas E. Gundersen Kay-Tee Khaw Adam S. Butterworth John Danesh Timothy Spector Thomas J. Wang Elina Hyppönen Peter Kraft Douglas P. Kiel Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels |
| description |
Vitamin D deficiency is associated with multiple human pathologic conditions. In a genome-wide association study of 79,366 individuals, Jiang et al. replicate four and identify two new genetic loci for serum levels of 25-hydroxyvitamin D and find evidence for a shared genetic basis with autoimmune diseases. |
| format |
article |
| author |
Xia Jiang Paul F. O’Reilly Hugues Aschard Yi-Hsiang Hsu J. Brent Richards Josée Dupuis Erik Ingelsson David Karasik Stefan Pilz Diane Berry Bryan Kestenbaum Jusheng Zheng Jianan Luan Eleni Sofianopoulou Elizabeth A. Streeten Demetrius Albanes Pamela L. Lutsey Lu Yao Weihong Tang Michael J. Econs Henri Wallaschofski Henry Völzke Ang Zhou Chris Power Mark I. McCarthy Erin D. Michos Eric Boerwinkle Stephanie J. Weinstein Neal D. Freedman Wen-Yi Huang Natasja M. Van Schoor Nathalie van der Velde Lisette C. P. G. M. de Groot Anke Enneman L. Adrienne Cupples Sarah L. Booth Ramachandran S. Vasan Ching-Ti Liu Yanhua Zhou Samuli Ripatti Claes Ohlsson Liesbeth Vandenput Mattias Lorentzon Johan G. Eriksson M. Kyla Shea Denise K. Houston Stephen B. Kritchevsky Yongmei Liu Kurt K. Lohman Luigi Ferrucci Munro Peacock Christian Gieger Marian Beekman Eline Slagboom Joris Deelen Diana van Heemst Marcus E. Kleber Winfried März Ian H. de Boer Alexis C. Wood Jerome I. Rotter Stephen S. Rich Cassianne Robinson-Cohen Martin den Heijer Marjo-Riitta Jarvelin Alana Cavadino Peter K. Joshi James F. Wilson Caroline Hayward Lars Lind Karl Michaëlsson Stella Trompet M. Carola Zillikens Andre G. Uitterlinden Fernando Rivadeneira Linda Broer Lina Zgaga Harry Campbell Evropi Theodoratou Susan M. Farrington Maria Timofeeva Malcolm G. Dunlop Ana M. Valdes Emmi Tikkanen Terho Lehtimäki Leo-Pekka Lyytikäinen Mika Kähönen Olli T. Raitakari Vera Mikkilä M. Arfan Ikram Naveed Sattar J. Wouter Jukema Nicholas J. Wareham Claudia Langenberg Nita G. Forouhi Thomas E. Gundersen Kay-Tee Khaw Adam S. Butterworth John Danesh Timothy Spector Thomas J. Wang Elina Hyppönen Peter Kraft Douglas P. Kiel |
| author_facet |
Xia Jiang Paul F. O’Reilly Hugues Aschard Yi-Hsiang Hsu J. Brent Richards Josée Dupuis Erik Ingelsson David Karasik Stefan Pilz Diane Berry Bryan Kestenbaum Jusheng Zheng Jianan Luan Eleni Sofianopoulou Elizabeth A. Streeten Demetrius Albanes Pamela L. Lutsey Lu Yao Weihong Tang Michael J. Econs Henri Wallaschofski Henry Völzke Ang Zhou Chris Power Mark I. McCarthy Erin D. Michos Eric Boerwinkle Stephanie J. Weinstein Neal D. Freedman Wen-Yi Huang Natasja M. Van Schoor Nathalie van der Velde Lisette C. P. G. M. de Groot Anke Enneman L. Adrienne Cupples Sarah L. Booth Ramachandran S. Vasan Ching-Ti Liu Yanhua Zhou Samuli Ripatti Claes Ohlsson Liesbeth Vandenput Mattias Lorentzon Johan G. Eriksson M. Kyla Shea Denise K. Houston Stephen B. Kritchevsky Yongmei Liu Kurt K. Lohman Luigi Ferrucci Munro Peacock Christian Gieger Marian Beekman Eline Slagboom Joris Deelen Diana van Heemst Marcus E. Kleber Winfried März Ian H. de Boer Alexis C. Wood Jerome I. Rotter Stephen S. Rich Cassianne Robinson-Cohen Martin den Heijer Marjo-Riitta Jarvelin Alana Cavadino Peter K. Joshi James F. Wilson Caroline Hayward Lars Lind Karl Michaëlsson Stella Trompet M. Carola Zillikens Andre G. Uitterlinden Fernando Rivadeneira Linda Broer Lina Zgaga Harry Campbell Evropi Theodoratou Susan M. Farrington Maria Timofeeva Malcolm G. Dunlop Ana M. Valdes Emmi Tikkanen Terho Lehtimäki Leo-Pekka Lyytikäinen Mika Kähönen Olli T. Raitakari Vera Mikkilä M. Arfan Ikram Naveed Sattar J. Wouter Jukema Nicholas J. Wareham Claudia Langenberg Nita G. Forouhi Thomas E. Gundersen Kay-Tee Khaw Adam S. Butterworth John Danesh Timothy Spector Thomas J. Wang Elina Hyppönen Peter Kraft Douglas P. Kiel |
| author_sort |
Xia Jiang |
| title |
Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels |
| title_short |
Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels |
| title_full |
Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels |
| title_fullStr |
Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels |
| title_full_unstemmed |
Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels |
| title_sort |
genome-wide association study in 79,366 european-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin d levels |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/45ceebb3cb0e4473b2cfdeb800d4099c |
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