Altered connection properties of important network hubs may be neural risk factors for individuals with primary insomnia

Abstract Primary insomnia (PIs) is highly prevalent and can lead to adverse socioeconomic impacts, but the underlying mechanism of its complex brain network impairment remains largely unknown. Functional studies are too few and diverse in methodology, which makes it difficult to glean general conclu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xuming Liu, Jiyong Zheng, Bi-Xia Liu, Xi-Jian Dai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/45cf1a2587aa4255999a0c4c7daafbbf
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:45cf1a2587aa4255999a0c4c7daafbbf
record_format	dspace
spelling	oai:doaj.org-article:45cf1a2587aa4255999a0c4c7daafbbf2021-12-02T15:08:56ZAltered connection properties of important network hubs may be neural risk factors for individuals with primary insomnia10.1038/s41598-018-23699-32045-2322https://doaj.org/article/45cf1a2587aa4255999a0c4c7daafbbf2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-23699-3https://doaj.org/toc/2045-2322Abstract Primary insomnia (PIs) is highly prevalent and can lead to adverse socioeconomic impacts, but the underlying mechanism of its complex brain network impairment remains largely unknown. Functional studies are too few and diverse in methodology, which makes it difficult to glean general conclusions. To answer this question, we first used graph theory-based network analyse, together with seed-based functional connectivity approach, to characterize the topology architecture of whole-brain functional networks associated with PIs. Forty-eight subjects with PIs and 48 age/sex/education-matched good sleepers were recruited. We found PIs is associated with altered connection properties of intra-networks within the executive control network, default mode network and salience network, and inter-network between auditory language comprehension center and executive control network. These complex networks were correlated with negative emotions and insomnia severity in the PIs group. Altered connection properties of these network hubs appeared to be neural risk factors for neuropsychological changes of PIs, and might be used as potential neuroimaging markers to distinguish the PIs from the good sleepers. These findings highlight the role of functional connectivity in the pathophysiology of PIs, and may underlie the neural mechanisms of etiology of PIs.Xuming LiuJiyong ZhengBi-Xia LiuXi-Jian DaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xuming Liu Jiyong Zheng Bi-Xia Liu Xi-Jian Dai Altered connection properties of important network hubs may be neural risk factors for individuals with primary insomnia
description	Abstract Primary insomnia (PIs) is highly prevalent and can lead to adverse socioeconomic impacts, but the underlying mechanism of its complex brain network impairment remains largely unknown. Functional studies are too few and diverse in methodology, which makes it difficult to glean general conclusions. To answer this question, we first used graph theory-based network analyse, together with seed-based functional connectivity approach, to characterize the topology architecture of whole-brain functional networks associated with PIs. Forty-eight subjects with PIs and 48 age/sex/education-matched good sleepers were recruited. We found PIs is associated with altered connection properties of intra-networks within the executive control network, default mode network and salience network, and inter-network between auditory language comprehension center and executive control network. These complex networks were correlated with negative emotions and insomnia severity in the PIs group. Altered connection properties of these network hubs appeared to be neural risk factors for neuropsychological changes of PIs, and might be used as potential neuroimaging markers to distinguish the PIs from the good sleepers. These findings highlight the role of functional connectivity in the pathophysiology of PIs, and may underlie the neural mechanisms of etiology of PIs.
format	article
author	Xuming Liu Jiyong Zheng Bi-Xia Liu Xi-Jian Dai
author_facet	Xuming Liu Jiyong Zheng Bi-Xia Liu Xi-Jian Dai
author_sort	Xuming Liu
title	Altered connection properties of important network hubs may be neural risk factors for individuals with primary insomnia
title_short	Altered connection properties of important network hubs may be neural risk factors for individuals with primary insomnia
title_full	Altered connection properties of important network hubs may be neural risk factors for individuals with primary insomnia
title_fullStr	Altered connection properties of important network hubs may be neural risk factors for individuals with primary insomnia
title_full_unstemmed	Altered connection properties of important network hubs may be neural risk factors for individuals with primary insomnia
title_sort	altered connection properties of important network hubs may be neural risk factors for individuals with primary insomnia
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/45cf1a2587aa4255999a0c4c7daafbbf
work_keys_str_mv	AT xumingliu alteredconnectionpropertiesofimportantnetworkhubsmaybeneuralriskfactorsforindividualswithprimaryinsomnia AT jiyongzheng alteredconnectionpropertiesofimportantnetworkhubsmaybeneuralriskfactorsforindividualswithprimaryinsomnia AT bixialiu alteredconnectionpropertiesofimportantnetworkhubsmaybeneuralriskfactorsforindividualswithprimaryinsomnia AT xijiandai alteredconnectionpropertiesofimportantnetworkhubsmaybeneuralriskfactorsforindividualswithprimaryinsomnia
_version_	1718387933683122176

Altered connection properties of important network hubs may be neural risk factors for individuals with primary insomnia

Ejemplares similares