Optimisation of embryonic and larval ECG measurement in zebrafish for quantifying the effect of QT prolonging drugs.

Effective chemical compound toxicity screening is of paramount importance for safe cardiac drug development. Using mammals in preliminary screening for detection of cardiac dysfunction by electrocardiography (ECG) is costly and requires a large number of animals. Alternatively, zebrafish embryos can...

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Autores principales: Sundeep Singh Dhillon, Eva Dóró, István Magyary, Stuart Egginton, Attila Sík, Ferenc Müller
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/45d5c1deb1fc497ab75c5805542b1a35
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