METTL14 gene polymorphisms decrease Wilms tumor susceptibility in Chinese children

Abstract Background Wilms tumor is a highly heritable malignancy. Aberrant METTL14, a critical component of N6-methyladenosine (m6A) methyltransferase, is involved in carcinogenesis. The association between genetic variants in the METTL14 gene and Wilms tumor susceptibility remains to be fully eluci...

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Autores principales:	Zhenjian Zhuo, Rui-Xi Hua, Huizhu Zhang, Huiran Lin, Wen Fu, Jinhong Zhu, Jiwen Cheng, Jiao Zhang, Suhong Li, Haixia Zhou, Huimin Xia, Guochang Liu, Wei Jia, Jing He
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Wilms tumor Risk METTL14 Polymorphism Case-control study Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/45dc3912cf724c6e9691323b2671ab05
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spelling	oai:doaj.org-article:45dc3912cf724c6e9691323b2671ab052021-12-05T12:19:32ZMETTL14 gene polymorphisms decrease Wilms tumor susceptibility in Chinese children10.1186/s12885-021-09019-51471-2407https://doaj.org/article/45dc3912cf724c6e9691323b2671ab052021-12-01T00:00:00Zhttps://doi.org/10.1186/s12885-021-09019-5https://doaj.org/toc/1471-2407Abstract Background Wilms tumor is a highly heritable malignancy. Aberrant METTL14, a critical component of N6-methyladenosine (m6A) methyltransferase, is involved in carcinogenesis. The association between genetic variants in the METTL14 gene and Wilms tumor susceptibility remains to be fully elucidated. We aimed to assess whether variants within this gene are implicated in Wilms tumor susceptibility. Methods A total of 403 patients and 1198 controls were analyzed. METTL14 genotypes were assessed by TaqMan genotyping assay. Result Among the five SNPs analyzed, rs1064034 T > A and rs298982 G > A exhibited a significant association with decreased susceptibility to Wilms tumor. Moreover, the joint analysis revealed that the combination of five protective genotypes exerted significantly more protective effects against Wilms tumor than 0–4 protective genotypes with an OR of 0.69. The stratified analysis further identified the protective effect of rs1064034 T > A, rs298982 G > A, and combined five protective genotypes in specific subgroups. The above significant associations were further validated by haplotype analysis and false-positive report probability analysis. Preliminary mechanism exploration indicated that rs1064034 T > A and rs298982 G > A are correlated with the expression and splicing event of their surrounding genes. Conclusions Collectively, our results suggest that METTL14 gene SNPs may be genetic modifiers for the development of Wilms tumor.Zhenjian ZhuoRui-Xi HuaHuizhu ZhangHuiran LinWen FuJinhong ZhuJiwen ChengJiao ZhangSuhong LiHaixia ZhouHuimin XiaGuochang LiuWei JiaJing HeBMCarticleWilms tumorRiskMETTL14PolymorphismCase-control studyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBMC Cancer, Vol 21, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Wilms tumor Risk METTL14 Polymorphism Case-control study Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Wilms tumor Risk METTL14 Polymorphism Case-control study Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Zhenjian Zhuo Rui-Xi Hua Huizhu Zhang Huiran Lin Wen Fu Jinhong Zhu Jiwen Cheng Jiao Zhang Suhong Li Haixia Zhou Huimin Xia Guochang Liu Wei Jia Jing He METTL14 gene polymorphisms decrease Wilms tumor susceptibility in Chinese children
description	Abstract Background Wilms tumor is a highly heritable malignancy. Aberrant METTL14, a critical component of N6-methyladenosine (m6A) methyltransferase, is involved in carcinogenesis. The association between genetic variants in the METTL14 gene and Wilms tumor susceptibility remains to be fully elucidated. We aimed to assess whether variants within this gene are implicated in Wilms tumor susceptibility. Methods A total of 403 patients and 1198 controls were analyzed. METTL14 genotypes were assessed by TaqMan genotyping assay. Result Among the five SNPs analyzed, rs1064034 T > A and rs298982 G > A exhibited a significant association with decreased susceptibility to Wilms tumor. Moreover, the joint analysis revealed that the combination of five protective genotypes exerted significantly more protective effects against Wilms tumor than 0–4 protective genotypes with an OR of 0.69. The stratified analysis further identified the protective effect of rs1064034 T > A, rs298982 G > A, and combined five protective genotypes in specific subgroups. The above significant associations were further validated by haplotype analysis and false-positive report probability analysis. Preliminary mechanism exploration indicated that rs1064034 T > A and rs298982 G > A are correlated with the expression and splicing event of their surrounding genes. Conclusions Collectively, our results suggest that METTL14 gene SNPs may be genetic modifiers for the development of Wilms tumor.
format	article
author	Zhenjian Zhuo Rui-Xi Hua Huizhu Zhang Huiran Lin Wen Fu Jinhong Zhu Jiwen Cheng Jiao Zhang Suhong Li Haixia Zhou Huimin Xia Guochang Liu Wei Jia Jing He
author_facet	Zhenjian Zhuo Rui-Xi Hua Huizhu Zhang Huiran Lin Wen Fu Jinhong Zhu Jiwen Cheng Jiao Zhang Suhong Li Haixia Zhou Huimin Xia Guochang Liu Wei Jia Jing He
author_sort	Zhenjian Zhuo
title	METTL14 gene polymorphisms decrease Wilms tumor susceptibility in Chinese children
title_short	METTL14 gene polymorphisms decrease Wilms tumor susceptibility in Chinese children
title_full	METTL14 gene polymorphisms decrease Wilms tumor susceptibility in Chinese children
title_fullStr	METTL14 gene polymorphisms decrease Wilms tumor susceptibility in Chinese children
title_full_unstemmed	METTL14 gene polymorphisms decrease Wilms tumor susceptibility in Chinese children
title_sort	mettl14 gene polymorphisms decrease wilms tumor susceptibility in chinese children
publisher	BMC
publishDate	2021
url	https://doaj.org/article/45dc3912cf724c6e9691323b2671ab05
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METTL14 gene polymorphisms decrease Wilms tumor susceptibility in Chinese children

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