Effects of the <i>Escherichia coli</i> Bacterial Toxin Cytotoxic Necrotizing Factor 1 on Different Human and Animal Cells: A Systematic Review

Cytotoxic necrotizing factor 1 (CNF1) is a bacterial virulence factor, the target of which is represented by Rho GTPases, small proteins involved in a huge number of crucial cellular processes. CNF1, due to its ability to modulate the activity of Rho GTPases, represents a widely used tool to unravel...

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Autores principales:	Francesca Carlini, Zaira Maroccia, Carla Fiorentini, Sara Travaglione, Alessia Fabbri
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Rho GTP-binding proteins cytotoxic necrotizing factor type 1 actin cytoskeleton mitochondria apoptosis primary cell culture Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/45dc3e794d90428ea268b27f1cf68a49
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spelling	oai:doaj.org-article:45dc3e794d90428ea268b27f1cf68a492021-11-25T17:58:19ZEffects of the <i>Escherichia coli</i> Bacterial Toxin Cytotoxic Necrotizing Factor 1 on Different Human and Animal Cells: A Systematic Review10.3390/ijms2222126101422-00671661-6596https://doaj.org/article/45dc3e794d90428ea268b27f1cf68a492021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12610https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Cytotoxic necrotizing factor 1 (CNF1) is a bacterial virulence factor, the target of which is represented by Rho GTPases, small proteins involved in a huge number of crucial cellular processes. CNF1, due to its ability to modulate the activity of Rho GTPases, represents a widely used tool to unravel the role played by these regulatory proteins in different biological processes. In this review, we summarized the data available in the scientific literature concerning the observed in vitro effects induced by CNF1. An article search was performed on electronic bibliographic resources. Screenings were performed of titles, abstracts, and full-texts according to PRISMA guidelines, whereas eligibility criteria were defined for in vitro studies. We identified a total of 299 records by electronic article search and included 76 original peer-reviewed scientific articles reporting morphological or biochemical modifications induced in vitro by soluble CNF1, either recombinant or from pathogenic <i>Escherichia coli</i> extracts highly purified with chromatographic methods. Most of the described CNF1-induced effects on cultured cells are ascribable to the modulating activity of the toxin on Rho GTPases and the consequent effects on actin cytoskeleton organization. All in all, the present review could be a prospectus about the CNF1-induced effects on cultured cells reported so far.Francesca CarliniZaira MarocciaCarla FiorentiniSara TravaglioneAlessia FabbriMDPI AGarticleRho GTP-binding proteinscytotoxic necrotizing factor type 1actin cytoskeletonmitochondriaapoptosisprimary cell cultureBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12610, p 12610 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Rho GTP-binding proteins cytotoxic necrotizing factor type 1 actin cytoskeleton mitochondria apoptosis primary cell culture Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	Rho GTP-binding proteins cytotoxic necrotizing factor type 1 actin cytoskeleton mitochondria apoptosis primary cell culture Biology (General) QH301-705.5 Chemistry QD1-999 Francesca Carlini Zaira Maroccia Carla Fiorentini Sara Travaglione Alessia Fabbri Effects of the <i>Escherichia coli</i> Bacterial Toxin Cytotoxic Necrotizing Factor 1 on Different Human and Animal Cells: A Systematic Review
description	Cytotoxic necrotizing factor 1 (CNF1) is a bacterial virulence factor, the target of which is represented by Rho GTPases, small proteins involved in a huge number of crucial cellular processes. CNF1, due to its ability to modulate the activity of Rho GTPases, represents a widely used tool to unravel the role played by these regulatory proteins in different biological processes. In this review, we summarized the data available in the scientific literature concerning the observed in vitro effects induced by CNF1. An article search was performed on electronic bibliographic resources. Screenings were performed of titles, abstracts, and full-texts according to PRISMA guidelines, whereas eligibility criteria were defined for in vitro studies. We identified a total of 299 records by electronic article search and included 76 original peer-reviewed scientific articles reporting morphological or biochemical modifications induced in vitro by soluble CNF1, either recombinant or from pathogenic <i>Escherichia coli</i> extracts highly purified with chromatographic methods. Most of the described CNF1-induced effects on cultured cells are ascribable to the modulating activity of the toxin on Rho GTPases and the consequent effects on actin cytoskeleton organization. All in all, the present review could be a prospectus about the CNF1-induced effects on cultured cells reported so far.
format	article
author	Francesca Carlini Zaira Maroccia Carla Fiorentini Sara Travaglione Alessia Fabbri
author_facet	Francesca Carlini Zaira Maroccia Carla Fiorentini Sara Travaglione Alessia Fabbri
author_sort	Francesca Carlini
title	Effects of the <i>Escherichia coli</i> Bacterial Toxin Cytotoxic Necrotizing Factor 1 on Different Human and Animal Cells: A Systematic Review
title_short	Effects of the <i>Escherichia coli</i> Bacterial Toxin Cytotoxic Necrotizing Factor 1 on Different Human and Animal Cells: A Systematic Review
title_full	Effects of the <i>Escherichia coli</i> Bacterial Toxin Cytotoxic Necrotizing Factor 1 on Different Human and Animal Cells: A Systematic Review
title_fullStr	Effects of the <i>Escherichia coli</i> Bacterial Toxin Cytotoxic Necrotizing Factor 1 on Different Human and Animal Cells: A Systematic Review
title_full_unstemmed	Effects of the <i>Escherichia coli</i> Bacterial Toxin Cytotoxic Necrotizing Factor 1 on Different Human and Animal Cells: A Systematic Review
title_sort	effects of the <i>escherichia coli</i> bacterial toxin cytotoxic necrotizing factor 1 on different human and animal cells: a systematic review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/45dc3e794d90428ea268b27f1cf68a49
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Effects of the <i>Escherichia coli</i> Bacterial Toxin Cytotoxic Necrotizing Factor 1 on Different Human and Animal Cells: A Systematic Review

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