Unnecessary antibiotic treatment of children hospitalised with respiratory syncytial virus (RSV) bronchiolitis: risk factors and prescription patterns

ABSTRACT: Objectives: Respiratory syncytial virus (RSV) is a leading cause of respiratory tract infections, especially in young children. Antibiotics are often unnecessarily prescribed for the treatment of RSV. Such treatments affect antibiotic resistance in future bacterial infections of treated p...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Uri Obolski, Eias Kassem, Wasef Na'amnih, Shebly Tannous, Viktoria Kagan, Khitam Muhsen
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Antimicrobial resistance Antibiotic misuse Respiratory syncytial virus RSV Children Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/45dd63d34daa4879a478ee2c186ff04f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:45dd63d34daa4879a478ee2c186ff04f
record_format	dspace
spelling	oai:doaj.org-article:45dd63d34daa4879a478ee2c186ff04f2021-11-28T04:32:20ZUnnecessary antibiotic treatment of children hospitalised with respiratory syncytial virus (RSV) bronchiolitis: risk factors and prescription patterns2213-716510.1016/j.jgar.2021.10.015https://doaj.org/article/45dd63d34daa4879a478ee2c186ff04f2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2213716521002320https://doaj.org/toc/2213-7165ABSTRACT: Objectives: Respiratory syncytial virus (RSV) is a leading cause of respiratory tract infections, especially in young children. Antibiotics are often unnecessarily prescribed for the treatment of RSV. Such treatments affect antibiotic resistance in future bacterial infections of treated patients and the general population. This study aimed to understand risk factors for and patterns of unnecessary antibiotic prescription in children with RSV. Methods: In a single-centre, retrospective study in Israel, we obtained data for children aged ≤2 years (n = 1016) hospitalised for RSV bronchiolitis during 2008–2018 and ascertained not to have bacterial co-infections. Antibiotic misuse was defined as prescription of antibiotics during hospitalisation of the study population. Demographic and clinical variables were assessed as predictors of unnecessary antibiotic treatment in a multivariable logistic regression model. Results: The unnecessary antibiotic treatment rate of children infected with RSV and ascertained not to have a bacterial co-infection was estimated at 33.4% (95% CI 30.5–36.4%). An increased likelihood of antibiotic misuse was associated with drawing bacterial cultures and with variables indicative of a severe patient status such as lower oxygen saturation, higher body temperature, tachypnoea and prior recent emergency room visit. Older age and female sex were also associated with an increased likelihood of unnecessary antibiotic treatment. Conclusions: Unnecessary antibiotic treatment in RSV patients was very common and may be largely attributed to physicians’ perception of patients’ severity. Improving prescription guidelines, implementing antibiotic stewardship programmes and utilising decision support systems may help achieve a better balance between prescribing and withholding antibiotic treatment.Uri ObolskiEias KassemWasef Na'amnihShebly TannousViktoria KaganKhitam MuhsenElsevierarticleAntimicrobial resistanceAntibiotic misuseRespiratory syncytial virusRSVChildrenMicrobiologyQR1-502ENJournal of Global Antimicrobial Resistance, Vol 27, Iss , Pp 303-308 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Antimicrobial resistance Antibiotic misuse Respiratory syncytial virus RSV Children Microbiology QR1-502
spellingShingle	Antimicrobial resistance Antibiotic misuse Respiratory syncytial virus RSV Children Microbiology QR1-502 Uri Obolski Eias Kassem Wasef Na'amnih Shebly Tannous Viktoria Kagan Khitam Muhsen Unnecessary antibiotic treatment of children hospitalised with respiratory syncytial virus (RSV) bronchiolitis: risk factors and prescription patterns
description	ABSTRACT: Objectives: Respiratory syncytial virus (RSV) is a leading cause of respiratory tract infections, especially in young children. Antibiotics are often unnecessarily prescribed for the treatment of RSV. Such treatments affect antibiotic resistance in future bacterial infections of treated patients and the general population. This study aimed to understand risk factors for and patterns of unnecessary antibiotic prescription in children with RSV. Methods: In a single-centre, retrospective study in Israel, we obtained data for children aged ≤2 years (n = 1016) hospitalised for RSV bronchiolitis during 2008–2018 and ascertained not to have bacterial co-infections. Antibiotic misuse was defined as prescription of antibiotics during hospitalisation of the study population. Demographic and clinical variables were assessed as predictors of unnecessary antibiotic treatment in a multivariable logistic regression model. Results: The unnecessary antibiotic treatment rate of children infected with RSV and ascertained not to have a bacterial co-infection was estimated at 33.4% (95% CI 30.5–36.4%). An increased likelihood of antibiotic misuse was associated with drawing bacterial cultures and with variables indicative of a severe patient status such as lower oxygen saturation, higher body temperature, tachypnoea and prior recent emergency room visit. Older age and female sex were also associated with an increased likelihood of unnecessary antibiotic treatment. Conclusions: Unnecessary antibiotic treatment in RSV patients was very common and may be largely attributed to physicians’ perception of patients’ severity. Improving prescription guidelines, implementing antibiotic stewardship programmes and utilising decision support systems may help achieve a better balance between prescribing and withholding antibiotic treatment.
format	article
author	Uri Obolski Eias Kassem Wasef Na'amnih Shebly Tannous Viktoria Kagan Khitam Muhsen
author_facet	Uri Obolski Eias Kassem Wasef Na'amnih Shebly Tannous Viktoria Kagan Khitam Muhsen
author_sort	Uri Obolski
title	Unnecessary antibiotic treatment of children hospitalised with respiratory syncytial virus (RSV) bronchiolitis: risk factors and prescription patterns
title_short	Unnecessary antibiotic treatment of children hospitalised with respiratory syncytial virus (RSV) bronchiolitis: risk factors and prescription patterns
title_full	Unnecessary antibiotic treatment of children hospitalised with respiratory syncytial virus (RSV) bronchiolitis: risk factors and prescription patterns
title_fullStr	Unnecessary antibiotic treatment of children hospitalised with respiratory syncytial virus (RSV) bronchiolitis: risk factors and prescription patterns
title_full_unstemmed	Unnecessary antibiotic treatment of children hospitalised with respiratory syncytial virus (RSV) bronchiolitis: risk factors and prescription patterns
title_sort	unnecessary antibiotic treatment of children hospitalised with respiratory syncytial virus (rsv) bronchiolitis: risk factors and prescription patterns
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/45dd63d34daa4879a478ee2c186ff04f
work_keys_str_mv	AT uriobolski unnecessaryantibiotictreatmentofchildrenhospitalisedwithrespiratorysyncytialvirusrsvbronchiolitisriskfactorsandprescriptionpatterns AT eiaskassem unnecessaryantibiotictreatmentofchildrenhospitalisedwithrespiratorysyncytialvirusrsvbronchiolitisriskfactorsandprescriptionpatterns AT wasefnaamnih unnecessaryantibiotictreatmentofchildrenhospitalisedwithrespiratorysyncytialvirusrsvbronchiolitisriskfactorsandprescriptionpatterns AT sheblytannous unnecessaryantibiotictreatmentofchildrenhospitalisedwithrespiratorysyncytialvirusrsvbronchiolitisriskfactorsandprescriptionpatterns AT viktoriakagan unnecessaryantibiotictreatmentofchildrenhospitalisedwithrespiratorysyncytialvirusrsvbronchiolitisriskfactorsandprescriptionpatterns AT khitammuhsen unnecessaryantibiotictreatmentofchildrenhospitalisedwithrespiratorysyncytialvirusrsvbronchiolitisriskfactorsandprescriptionpatterns
_version_	1718408312411652096

Unnecessary antibiotic treatment of children hospitalised with respiratory syncytial virus (RSV) bronchiolitis: risk factors and prescription patterns

Ejemplares similares