Metabolomic biomarkers in serum and urine in women with preeclampsia.

<h4>Objective</h4>To explore the potential of magnetic resonance (MR) metabolomics for study of preeclampsia, for improved phenotyping and elucidating potential clues to etiology and pathogenesis.<h4>Methods</h4>Urine and serum samples from pregnant women with preeclampsia (n...

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Autores principales:	Marie Austdal, Ragnhild Bergene Skråstad, Astrid Solberg Gundersen, Rigmor Austgulen, Ann-Charlotte Iversen, Tone Frost Bathen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/45dfaac38eee425f8498df0bdc7b1b7a
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spelling	oai:doaj.org-article:45dfaac38eee425f8498df0bdc7b1b7a2021-11-18T08:27:52ZMetabolomic biomarkers in serum and urine in women with preeclampsia.1932-620310.1371/journal.pone.0091923https://doaj.org/article/45dfaac38eee425f8498df0bdc7b1b7a2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24637620/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>To explore the potential of magnetic resonance (MR) metabolomics for study of preeclampsia, for improved phenotyping and elucidating potential clues to etiology and pathogenesis.<h4>Methods</h4>Urine and serum samples from pregnant women with preeclampsia (n = 10), normal pregnancies (n = 10) and non-pregnant women (n = 10) matched by age and gestational age were analyzed with MR spectroscopy and subjected to multivariate analysis. Metabolites were then quantified and compared between groups.<h4>Results</h4>Urine and serum samples revealed clear differences between women with preeclampsia and both control groups (normal pregnant and non-pregnant women). Nine urine metabolites were significantly different between preeclampsia and the normal pregnant group. Urine samples from women with early onset preeclampsia clustered together in the multivariate analysis. The preeclampsia serum spectra showed higher levels of low and very-low density lipoproteins and lower levels of high-density lipoproteins when compared to both non-pregnant and normal pregnant women.<h4>Conclusion</h4>The MR determined metabolic profiles in urine and serum from women with preeclampsia are clearly different from normal pregnant women. The observed differences represent a potential to examine mechanisms underlying different preeclampsia phenotypes in urine and serum samples in larger studies. In addition, similarities between preeclampsia and cardiovascular disease in metabolomics are demonstrated.Marie AustdalRagnhild Bergene SkråstadAstrid Solberg GundersenRigmor AustgulenAnn-Charlotte IversenTone Frost BathenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 3, p e91923 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marie Austdal Ragnhild Bergene Skråstad Astrid Solberg Gundersen Rigmor Austgulen Ann-Charlotte Iversen Tone Frost Bathen Metabolomic biomarkers in serum and urine in women with preeclampsia.
description	<h4>Objective</h4>To explore the potential of magnetic resonance (MR) metabolomics for study of preeclampsia, for improved phenotyping and elucidating potential clues to etiology and pathogenesis.<h4>Methods</h4>Urine and serum samples from pregnant women with preeclampsia (n = 10), normal pregnancies (n = 10) and non-pregnant women (n = 10) matched by age and gestational age were analyzed with MR spectroscopy and subjected to multivariate analysis. Metabolites were then quantified and compared between groups.<h4>Results</h4>Urine and serum samples revealed clear differences between women with preeclampsia and both control groups (normal pregnant and non-pregnant women). Nine urine metabolites were significantly different between preeclampsia and the normal pregnant group. Urine samples from women with early onset preeclampsia clustered together in the multivariate analysis. The preeclampsia serum spectra showed higher levels of low and very-low density lipoproteins and lower levels of high-density lipoproteins when compared to both non-pregnant and normal pregnant women.<h4>Conclusion</h4>The MR determined metabolic profiles in urine and serum from women with preeclampsia are clearly different from normal pregnant women. The observed differences represent a potential to examine mechanisms underlying different preeclampsia phenotypes in urine and serum samples in larger studies. In addition, similarities between preeclampsia and cardiovascular disease in metabolomics are demonstrated.
format	article
author	Marie Austdal Ragnhild Bergene Skråstad Astrid Solberg Gundersen Rigmor Austgulen Ann-Charlotte Iversen Tone Frost Bathen
author_facet	Marie Austdal Ragnhild Bergene Skråstad Astrid Solberg Gundersen Rigmor Austgulen Ann-Charlotte Iversen Tone Frost Bathen
author_sort	Marie Austdal
title	Metabolomic biomarkers in serum and urine in women with preeclampsia.
title_short	Metabolomic biomarkers in serum and urine in women with preeclampsia.
title_full	Metabolomic biomarkers in serum and urine in women with preeclampsia.
title_fullStr	Metabolomic biomarkers in serum and urine in women with preeclampsia.
title_full_unstemmed	Metabolomic biomarkers in serum and urine in women with preeclampsia.
title_sort	metabolomic biomarkers in serum and urine in women with preeclampsia.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/45dfaac38eee425f8498df0bdc7b1b7a
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Metabolomic biomarkers in serum and urine in women with preeclampsia.

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