Randomized trial of weight loss on circulating ghrelin levels among breast cancer survivors

Abstract Obesity among breast cancer survivors is associated with increased risk for recurrence and mortality. The hormone ghrelin plays a role in initiating appetite and thus regulating body weight. This study aims to determine the effect of a lifestyle intervention on ghrelin levels in breast canc...

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Autores principales:	Leah Puklin, Brenda Cartmel, Maura Harrigan, Lingeng Lu, Fang-yong Li, Tara Sanft, Melinda L. Irwin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/45e297f893bf4fb1884f210c8624c2af
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spelling	oai:doaj.org-article:45e297f893bf4fb1884f210c8624c2af2021-12-02T16:51:02ZRandomized trial of weight loss on circulating ghrelin levels among breast cancer survivors10.1038/s41523-021-00260-62374-4677https://doaj.org/article/45e297f893bf4fb1884f210c8624c2af2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41523-021-00260-6https://doaj.org/toc/2374-4677Abstract Obesity among breast cancer survivors is associated with increased risk for recurrence and mortality. The hormone ghrelin plays a role in initiating appetite and thus regulating body weight. This study aims to determine the effect of a lifestyle intervention on ghrelin levels in breast cancer survivors with a body mass index (BMI) ≥ 25 kg/m2. The Lifestyle, Exercise, and Nutrition (LEAN) study was a 6-month randomized trial, examining the effectiveness of a weight loss intervention versus usual care in 151 breast cancer survivors with BMI ≥ 25 kg/m2. Ghrelin was measured in fasting baseline and 6-month blood samples. Baseline associations between ghrelin, body composition, and blood biomarkers were examined. Six-month change in ghrelin was compared between study arms. Ghrelin measurements were available for 149 women. At baseline, ghrelin was correlated with age (r = 0.28, p < 0.001) and inversely correlated with weight (r = −0.18, p = 0.03), lean body mass (r = −0.18, p = 0.02), and leptin (r = −0.18, p = 0.03). Over 6 months, ghrelin increased by 144 pg/mL (7.2%) in the intervention and decreased by 466 pg/mL (32.5%) in the usual care (p = 0.07). Among all women, greater weight loss was associated with an increase in ghrelin (p = 0.01). These findings indicate that weight loss, achieved through a lifestyle intervention, is associated with higher ghrelin levels in breast cancer survivors which may be informative for developing sustainable weight loss programming for this population. Future research should investigate the long term impacts of lifestyle interventions on ghrelin levels in the context of weight maintenance and weight regain.Leah PuklinBrenda CartmelMaura HarriganLingeng LuFang-yong LiTara SanftMelinda L. IrwinNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 7, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Leah Puklin Brenda Cartmel Maura Harrigan Lingeng Lu Fang-yong Li Tara Sanft Melinda L. Irwin Randomized trial of weight loss on circulating ghrelin levels among breast cancer survivors
description	Abstract Obesity among breast cancer survivors is associated with increased risk for recurrence and mortality. The hormone ghrelin plays a role in initiating appetite and thus regulating body weight. This study aims to determine the effect of a lifestyle intervention on ghrelin levels in breast cancer survivors with a body mass index (BMI) ≥ 25 kg/m2. The Lifestyle, Exercise, and Nutrition (LEAN) study was a 6-month randomized trial, examining the effectiveness of a weight loss intervention versus usual care in 151 breast cancer survivors with BMI ≥ 25 kg/m2. Ghrelin was measured in fasting baseline and 6-month blood samples. Baseline associations between ghrelin, body composition, and blood biomarkers were examined. Six-month change in ghrelin was compared between study arms. Ghrelin measurements were available for 149 women. At baseline, ghrelin was correlated with age (r = 0.28, p < 0.001) and inversely correlated with weight (r = −0.18, p = 0.03), lean body mass (r = −0.18, p = 0.02), and leptin (r = −0.18, p = 0.03). Over 6 months, ghrelin increased by 144 pg/mL (7.2%) in the intervention and decreased by 466 pg/mL (32.5%) in the usual care (p = 0.07). Among all women, greater weight loss was associated with an increase in ghrelin (p = 0.01). These findings indicate that weight loss, achieved through a lifestyle intervention, is associated with higher ghrelin levels in breast cancer survivors which may be informative for developing sustainable weight loss programming for this population. Future research should investigate the long term impacts of lifestyle interventions on ghrelin levels in the context of weight maintenance and weight regain.
format	article
author	Leah Puklin Brenda Cartmel Maura Harrigan Lingeng Lu Fang-yong Li Tara Sanft Melinda L. Irwin
author_facet	Leah Puklin Brenda Cartmel Maura Harrigan Lingeng Lu Fang-yong Li Tara Sanft Melinda L. Irwin
author_sort	Leah Puklin
title	Randomized trial of weight loss on circulating ghrelin levels among breast cancer survivors
title_short	Randomized trial of weight loss on circulating ghrelin levels among breast cancer survivors
title_full	Randomized trial of weight loss on circulating ghrelin levels among breast cancer survivors
title_fullStr	Randomized trial of weight loss on circulating ghrelin levels among breast cancer survivors
title_full_unstemmed	Randomized trial of weight loss on circulating ghrelin levels among breast cancer survivors
title_sort	randomized trial of weight loss on circulating ghrelin levels among breast cancer survivors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/45e297f893bf4fb1884f210c8624c2af
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Randomized trial of weight loss on circulating ghrelin levels among breast cancer survivors

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