Incomplete influenza A virus genomes occur frequently but are readily complemented during localized viral spread

The genome of influenza is often incomplete in infected cells, but the implications for infection remain unclear. Here, Jacobs et al. show that an average of 3.6 particles is necessary for productive infection and that coinfection supports efficient complementation within a host but not upon transmi...

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Autores principales:	Nathan T. Jacobs, Nina O. Onuoha, Alice Antia, John Steel, Rustom Antia, Anice C. Lowen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/45e9cb4fa49c46708c86f508bd22edcc
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spelling	oai:doaj.org-article:45e9cb4fa49c46708c86f508bd22edcc2021-12-02T14:40:00ZIncomplete influenza A virus genomes occur frequently but are readily complemented during localized viral spread10.1038/s41467-019-11428-x2041-1723https://doaj.org/article/45e9cb4fa49c46708c86f508bd22edcc2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11428-xhttps://doaj.org/toc/2041-1723The genome of influenza is often incomplete in infected cells, but the implications for infection remain unclear. Here, Jacobs et al. show that an average of 3.6 particles is necessary for productive infection and that coinfection supports efficient complementation within a host but not upon transmission to a new host.Nathan T. JacobsNina O. OnuohaAlice AntiaJohn SteelRustom AntiaAnice C. LowenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nathan T. Jacobs Nina O. Onuoha Alice Antia John Steel Rustom Antia Anice C. Lowen Incomplete influenza A virus genomes occur frequently but are readily complemented during localized viral spread
description	The genome of influenza is often incomplete in infected cells, but the implications for infection remain unclear. Here, Jacobs et al. show that an average of 3.6 particles is necessary for productive infection and that coinfection supports efficient complementation within a host but not upon transmission to a new host.
format	article
author	Nathan T. Jacobs Nina O. Onuoha Alice Antia John Steel Rustom Antia Anice C. Lowen
author_facet	Nathan T. Jacobs Nina O. Onuoha Alice Antia John Steel Rustom Antia Anice C. Lowen
author_sort	Nathan T. Jacobs
title	Incomplete influenza A virus genomes occur frequently but are readily complemented during localized viral spread
title_short	Incomplete influenza A virus genomes occur frequently but are readily complemented during localized viral spread
title_full	Incomplete influenza A virus genomes occur frequently but are readily complemented during localized viral spread
title_fullStr	Incomplete influenza A virus genomes occur frequently but are readily complemented during localized viral spread
title_full_unstemmed	Incomplete influenza A virus genomes occur frequently but are readily complemented during localized viral spread
title_sort	incomplete influenza a virus genomes occur frequently but are readily complemented during localized viral spread
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/45e9cb4fa49c46708c86f508bd22edcc
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Incomplete influenza A virus genomes occur frequently but are readily complemented during localized viral spread

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