Serum indices based on creatinine and cystatin C predict mortality in patients with non-dialysis chronic kidney disease

Abstract Serum indices based on creatinine and cystatin C, including creatinine/cystatin C ratio (Cr/CysC), ratio and difference of estimated glomerular filtration rate (eGFR) based on cystatin C and creatinine (eGFRcys/eGFRcre and eGFRDiff), and serum creatinine × eGFRcys, are recently identified s...

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Autores principales:	Yu-Li Lin, I-Chen Chang, Hung-Hsiang Liou, Chih-Hsien Wang, Yu-Hsien Lai, Chiu-Huang Kuo, Bang-Gee Hsu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/45ed05c5108c47b7bb3035211a5626a3
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spelling	oai:doaj.org-article:45ed05c5108c47b7bb3035211a5626a32021-12-02T18:51:52ZSerum indices based on creatinine and cystatin C predict mortality in patients with non-dialysis chronic kidney disease10.1038/s41598-021-96447-92045-2322https://doaj.org/article/45ed05c5108c47b7bb3035211a5626a32021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96447-9https://doaj.org/toc/2045-2322Abstract Serum indices based on creatinine and cystatin C, including creatinine/cystatin C ratio (Cr/CysC), ratio and difference of estimated glomerular filtration rate (eGFR) based on cystatin C and creatinine (eGFRcys/eGFRcre and eGFRDiff), and serum creatinine × eGFRcys, are recently identified serum markers for sarcopenia. We aimed to evaluate the association between these serum indices and mortality in patients with chronic kidney disease (CKD). A single-center retrospective cohort study included 1141 adult patients with stage 1–5 CKD between 2016 and 2018. Basic characteristics, comorbidities, laboratory parameters, and serum creatinine and cystatin C values were obtained. Patients were followed up until death, dialysis, transfer to another hospital, or end of the study. The median age (interquartile range) of our participants was 71 (62–81) years. During a median follow-up of 39 months, 116 (10.2%) patients died. Compared to the survivor group, Cr/CysC, eGFRcys/eGFRcre, eGFRDiff, and Cr × eGFRcys were all lower in the non-survivors (p < 0.001 for all). The receiver operating characteristic curves of serum indices for predicting mortality showed that all four indices had significant discriminative power. Based on the Cox proportional hazard models, lower values of four serum indices, both as continuous and categorical variables, independently predicted mortality. Our findings suggest that low serum indices of Cr/CysC, eGFRcys/eGFRcre, eGFRDiff, and Cr × eGFRcys are independent indicators of mortality in patients with non-dialysis CKD.Yu-Li LinI-Chen ChangHung-Hsiang LiouChih-Hsien WangYu-Hsien LaiChiu-Huang KuoBang-Gee HsuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yu-Li Lin I-Chen Chang Hung-Hsiang Liou Chih-Hsien Wang Yu-Hsien Lai Chiu-Huang Kuo Bang-Gee Hsu Serum indices based on creatinine and cystatin C predict mortality in patients with non-dialysis chronic kidney disease
description	Abstract Serum indices based on creatinine and cystatin C, including creatinine/cystatin C ratio (Cr/CysC), ratio and difference of estimated glomerular filtration rate (eGFR) based on cystatin C and creatinine (eGFRcys/eGFRcre and eGFRDiff), and serum creatinine × eGFRcys, are recently identified serum markers for sarcopenia. We aimed to evaluate the association between these serum indices and mortality in patients with chronic kidney disease (CKD). A single-center retrospective cohort study included 1141 adult patients with stage 1–5 CKD between 2016 and 2018. Basic characteristics, comorbidities, laboratory parameters, and serum creatinine and cystatin C values were obtained. Patients were followed up until death, dialysis, transfer to another hospital, or end of the study. The median age (interquartile range) of our participants was 71 (62–81) years. During a median follow-up of 39 months, 116 (10.2%) patients died. Compared to the survivor group, Cr/CysC, eGFRcys/eGFRcre, eGFRDiff, and Cr × eGFRcys were all lower in the non-survivors (p < 0.001 for all). The receiver operating characteristic curves of serum indices for predicting mortality showed that all four indices had significant discriminative power. Based on the Cox proportional hazard models, lower values of four serum indices, both as continuous and categorical variables, independently predicted mortality. Our findings suggest that low serum indices of Cr/CysC, eGFRcys/eGFRcre, eGFRDiff, and Cr × eGFRcys are independent indicators of mortality in patients with non-dialysis CKD.
format	article
author	Yu-Li Lin I-Chen Chang Hung-Hsiang Liou Chih-Hsien Wang Yu-Hsien Lai Chiu-Huang Kuo Bang-Gee Hsu
author_facet	Yu-Li Lin I-Chen Chang Hung-Hsiang Liou Chih-Hsien Wang Yu-Hsien Lai Chiu-Huang Kuo Bang-Gee Hsu
author_sort	Yu-Li Lin
title	Serum indices based on creatinine and cystatin C predict mortality in patients with non-dialysis chronic kidney disease
title_short	Serum indices based on creatinine and cystatin C predict mortality in patients with non-dialysis chronic kidney disease
title_full	Serum indices based on creatinine and cystatin C predict mortality in patients with non-dialysis chronic kidney disease
title_fullStr	Serum indices based on creatinine and cystatin C predict mortality in patients with non-dialysis chronic kidney disease
title_full_unstemmed	Serum indices based on creatinine and cystatin C predict mortality in patients with non-dialysis chronic kidney disease
title_sort	serum indices based on creatinine and cystatin c predict mortality in patients with non-dialysis chronic kidney disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/45ed05c5108c47b7bb3035211a5626a3
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_version_	1718377381674090496

Serum indices based on creatinine and cystatin C predict mortality in patients with non-dialysis chronic kidney disease

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