Specifically progressive deficits of brain functional marker in amnestic type mild cognitive impairment.

<h4>Background</h4>Deficits of the default mode network (DMN) have been demonstrated in subjects with amnestic type mild cognitive impairment (aMCI) who have a high risk of developing Alzheimer's disease (AD). However, no longitudinal study of this network has been reported in aMCI....

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Autores principales:	Feng Bai, David R Watson, Yongmei Shi, Yi Wang, Chunxian Yue, YuhuanTeng, Di Wu, Yonggui Yuan, Zhijun Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/45ed2472606d41d9a68840bb072ea61f
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spelling	oai:doaj.org-article:45ed2472606d41d9a68840bb072ea61f2021-11-04T06:08:33ZSpecifically progressive deficits of brain functional marker in amnestic type mild cognitive impairment.1932-620310.1371/journal.pone.0024271https://doaj.org/article/45ed2472606d41d9a68840bb072ea61f2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21935394/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Deficits of the default mode network (DMN) have been demonstrated in subjects with amnestic type mild cognitive impairment (aMCI) who have a high risk of developing Alzheimer's disease (AD). However, no longitudinal study of this network has been reported in aMCI. Identifying links between development of DMN and aMCI progression would be of considerable value in understanding brain changes underpinning aMCI and determining risk of conversion to AD.<h4>Methodology/principal findings</h4>Resting-state fMRI was acquired in aMCI subjects (n = 26) and controls (n = 18) at baseline and after approximately 20 months follow up. Independent component analysis was used to isolate the DMN in each participant. Differences in DMN between aMCI and controls were examined at baseline, and subsequent changes between baseline and follow-up were also assessed in the groups. Posterior cingulate cortex/precuneus (PCC/PCu) hyper-functional connectivity was observed at baseline in aMCI subjects, while a substantial decrement of these connections was evident at follow-up in aMCI subjects, compared to matched controls. Specifically, PCC/PCu dysfunction was positively related to the impairments of episodic memory from baseline to follow up in aMCI group.<h4>Conclusions/significance</h4>The patterns of longitudinal deficits of DMN may assist investigators to identify and monitor the development of aMCI.Feng BaiDavid R WatsonYongmei ShiYi WangChunxian YueYuhuanTengDi WuYonggui YuanZhijun ZhangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 9, p e24271 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Feng Bai David R Watson Yongmei Shi Yi Wang Chunxian Yue YuhuanTeng Di Wu Yonggui Yuan Zhijun Zhang Specifically progressive deficits of brain functional marker in amnestic type mild cognitive impairment.
description	<h4>Background</h4>Deficits of the default mode network (DMN) have been demonstrated in subjects with amnestic type mild cognitive impairment (aMCI) who have a high risk of developing Alzheimer's disease (AD). However, no longitudinal study of this network has been reported in aMCI. Identifying links between development of DMN and aMCI progression would be of considerable value in understanding brain changes underpinning aMCI and determining risk of conversion to AD.<h4>Methodology/principal findings</h4>Resting-state fMRI was acquired in aMCI subjects (n = 26) and controls (n = 18) at baseline and after approximately 20 months follow up. Independent component analysis was used to isolate the DMN in each participant. Differences in DMN between aMCI and controls were examined at baseline, and subsequent changes between baseline and follow-up were also assessed in the groups. Posterior cingulate cortex/precuneus (PCC/PCu) hyper-functional connectivity was observed at baseline in aMCI subjects, while a substantial decrement of these connections was evident at follow-up in aMCI subjects, compared to matched controls. Specifically, PCC/PCu dysfunction was positively related to the impairments of episodic memory from baseline to follow up in aMCI group.<h4>Conclusions/significance</h4>The patterns of longitudinal deficits of DMN may assist investigators to identify and monitor the development of aMCI.
format	article
author	Feng Bai David R Watson Yongmei Shi Yi Wang Chunxian Yue YuhuanTeng Di Wu Yonggui Yuan Zhijun Zhang
author_facet	Feng Bai David R Watson Yongmei Shi Yi Wang Chunxian Yue YuhuanTeng Di Wu Yonggui Yuan Zhijun Zhang
author_sort	Feng Bai
title	Specifically progressive deficits of brain functional marker in amnestic type mild cognitive impairment.
title_short	Specifically progressive deficits of brain functional marker in amnestic type mild cognitive impairment.
title_full	Specifically progressive deficits of brain functional marker in amnestic type mild cognitive impairment.
title_fullStr	Specifically progressive deficits of brain functional marker in amnestic type mild cognitive impairment.
title_full_unstemmed	Specifically progressive deficits of brain functional marker in amnestic type mild cognitive impairment.
title_sort	specifically progressive deficits of brain functional marker in amnestic type mild cognitive impairment.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/45ed2472606d41d9a68840bb072ea61f
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Specifically progressive deficits of brain functional marker in amnestic type mild cognitive impairment.

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