Oral Exposure to Tributyltin Induced Behavioral Abnormality and Oxidative Stress in the Eyes and Brains of Juvenile Japanese Medaka (<i>Oryzias latipes</i>)

The widely used compound tributyltin (TBT), which can be continuously detected in aquatic species and seafood, may induce diverse adverse effects on aquatic organisms. However, little is known regarding the mechanistic links between behavioral abnormality and oxidative stress in different fish tissu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yanhong Shi, Chen Chen, Ming Li, Lei Liu, Kejun Dong, Kun Chen, Xuchun Qiu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	tributyltin Japanese medaka behavior oxidative stress ATPase Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/45ed5feb1d3940d89053f21f831d90b3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:45ed5feb1d3940d89053f21f831d90b3
record_format	dspace
spelling	oai:doaj.org-article:45ed5feb1d3940d89053f21f831d90b32021-11-25T16:25:18ZOral Exposure to Tributyltin Induced Behavioral Abnormality and Oxidative Stress in the Eyes and Brains of Juvenile Japanese Medaka (<i>Oryzias latipes</i>)10.3390/antiox101116472076-3921https://doaj.org/article/45ed5feb1d3940d89053f21f831d90b32021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1647https://doaj.org/toc/2076-3921The widely used compound tributyltin (TBT), which can be continuously detected in aquatic species and seafood, may induce diverse adverse effects on aquatic organisms. However, little is known regarding the mechanistic links between behavioral abnormality and oxidative stress in different fish tissues in response to oral TBT exposure. Herein, juvenile Japanese medaka (<i>Oryzias latipes</i>) were orally exposed to TBT at 1 and 10 ng/g-bw/d for four weeks. After exposure, the locomotor activity and social interaction of juvenile medaka were found to be significantly reduced in the 10 ng/g-bw/d TBT-exposed group. Furthermore, the antioxidant biomarkers in different tissues of juvenile medaka showed different levels of sensitivity to TBT exposure. The eye superoxide dismutase (SOD) activities markedly increased in both groups exposed to 1 and 10 ng/g-bw/d TBT, while the eye and brain malondialdehyde (MDA) levels increased in the higher dose group. Furthermore, the eye and brain ATPase activities markedly declined in the 1 ng/g-bw/d TBT-exposed group. A correlation analysis revealed that the decreased locomotor activity and social interaction in medaka were associated with the eye antioxidant enzyme (i.e., SOD and catalase (CAT)) activity and brain oxidative damage level. Thus, our findings suggested that there might be some mechanistic links between the behavioral abnormality induced by TBT exposure and oxidative stress in the eyes and brains of medaka. Thus, our findings indicate that the impacts of oral exposure to TBT should be considered to better assess its risk to the aquatic ecosystem and human health.Yanhong ShiChen ChenMing LiLei LiuKejun DongKun ChenXuchun QiuMDPI AGarticletributyltinJapanese medakabehavioroxidative stressATPaseTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1647, p 1647 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tributyltin Japanese medaka behavior oxidative stress ATPase Therapeutics. Pharmacology RM1-950
spellingShingle	tributyltin Japanese medaka behavior oxidative stress ATPase Therapeutics. Pharmacology RM1-950 Yanhong Shi Chen Chen Ming Li Lei Liu Kejun Dong Kun Chen Xuchun Qiu Oral Exposure to Tributyltin Induced Behavioral Abnormality and Oxidative Stress in the Eyes and Brains of Juvenile Japanese Medaka (<i>Oryzias latipes</i>)
description	The widely used compound tributyltin (TBT), which can be continuously detected in aquatic species and seafood, may induce diverse adverse effects on aquatic organisms. However, little is known regarding the mechanistic links between behavioral abnormality and oxidative stress in different fish tissues in response to oral TBT exposure. Herein, juvenile Japanese medaka (<i>Oryzias latipes</i>) were orally exposed to TBT at 1 and 10 ng/g-bw/d for four weeks. After exposure, the locomotor activity and social interaction of juvenile medaka were found to be significantly reduced in the 10 ng/g-bw/d TBT-exposed group. Furthermore, the antioxidant biomarkers in different tissues of juvenile medaka showed different levels of sensitivity to TBT exposure. The eye superoxide dismutase (SOD) activities markedly increased in both groups exposed to 1 and 10 ng/g-bw/d TBT, while the eye and brain malondialdehyde (MDA) levels increased in the higher dose group. Furthermore, the eye and brain ATPase activities markedly declined in the 1 ng/g-bw/d TBT-exposed group. A correlation analysis revealed that the decreased locomotor activity and social interaction in medaka were associated with the eye antioxidant enzyme (i.e., SOD and catalase (CAT)) activity and brain oxidative damage level. Thus, our findings suggested that there might be some mechanistic links between the behavioral abnormality induced by TBT exposure and oxidative stress in the eyes and brains of medaka. Thus, our findings indicate that the impacts of oral exposure to TBT should be considered to better assess its risk to the aquatic ecosystem and human health.
format	article
author	Yanhong Shi Chen Chen Ming Li Lei Liu Kejun Dong Kun Chen Xuchun Qiu
author_facet	Yanhong Shi Chen Chen Ming Li Lei Liu Kejun Dong Kun Chen Xuchun Qiu
author_sort	Yanhong Shi
title	Oral Exposure to Tributyltin Induced Behavioral Abnormality and Oxidative Stress in the Eyes and Brains of Juvenile Japanese Medaka (<i>Oryzias latipes</i>)
title_short	Oral Exposure to Tributyltin Induced Behavioral Abnormality and Oxidative Stress in the Eyes and Brains of Juvenile Japanese Medaka (<i>Oryzias latipes</i>)
title_full	Oral Exposure to Tributyltin Induced Behavioral Abnormality and Oxidative Stress in the Eyes and Brains of Juvenile Japanese Medaka (<i>Oryzias latipes</i>)
title_fullStr	Oral Exposure to Tributyltin Induced Behavioral Abnormality and Oxidative Stress in the Eyes and Brains of Juvenile Japanese Medaka (<i>Oryzias latipes</i>)
title_full_unstemmed	Oral Exposure to Tributyltin Induced Behavioral Abnormality and Oxidative Stress in the Eyes and Brains of Juvenile Japanese Medaka (<i>Oryzias latipes</i>)
title_sort	oral exposure to tributyltin induced behavioral abnormality and oxidative stress in the eyes and brains of juvenile japanese medaka (<i>oryzias latipes</i>)
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/45ed5feb1d3940d89053f21f831d90b3
work_keys_str_mv	AT yanhongshi oralexposuretotributyltininducedbehavioralabnormalityandoxidativestressintheeyesandbrainsofjuvenilejapanesemedakaioryziaslatipesi AT chenchen oralexposuretotributyltininducedbehavioralabnormalityandoxidativestressintheeyesandbrainsofjuvenilejapanesemedakaioryziaslatipesi AT mingli oralexposuretotributyltininducedbehavioralabnormalityandoxidativestressintheeyesandbrainsofjuvenilejapanesemedakaioryziaslatipesi AT leiliu oralexposuretotributyltininducedbehavioralabnormalityandoxidativestressintheeyesandbrainsofjuvenilejapanesemedakaioryziaslatipesi AT kejundong oralexposuretotributyltininducedbehavioralabnormalityandoxidativestressintheeyesandbrainsofjuvenilejapanesemedakaioryziaslatipesi AT kunchen oralexposuretotributyltininducedbehavioralabnormalityandoxidativestressintheeyesandbrainsofjuvenilejapanesemedakaioryziaslatipesi AT xuchunqiu oralexposuretotributyltininducedbehavioralabnormalityandoxidativestressintheeyesandbrainsofjuvenilejapanesemedakaioryziaslatipesi
_version_	1718413195663638528

Oral Exposure to Tributyltin Induced Behavioral Abnormality and Oxidative Stress in the Eyes and Brains of Juvenile Japanese Medaka (<i>Oryzias latipes</i>)

Ejemplares similares