Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts

Pleiotropic loci and genome-wide genetic correlations have identified shared heritability across some types of cancers. Here, the authors perform genome-wide association studies and characterize pan-cancer heritability and pleiotropy in individuals of European ancestry across 18 cancer types from tw...

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Autores principales:	Sara R. Rashkin, Rebecca E. Graff, Linda Kachuri, Khanh K. Thai, Stacey E. Alexeeff, Maruta A. Blatchins, Taylor B. Cavazos, Douglas A. Corley, Nima C. Emami, Joshua D. Hoffman, Eric Jorgenson, Lawrence H. Kushi, Travis J. Meyers, Stephen K. Van Den Eeden, Elad Ziv, Laurel A. Habel, Thomas J. Hoffmann, Lori C. Sakoda, John S. Witte
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/45eda6708b934235846a8a794af520d2
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spelling	oai:doaj.org-article:45eda6708b934235846a8a794af520d22021-12-02T16:38:50ZPan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts10.1038/s41467-020-18246-62041-1723https://doaj.org/article/45eda6708b934235846a8a794af520d22020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18246-6https://doaj.org/toc/2041-1723Pleiotropic loci and genome-wide genetic correlations have identified shared heritability across some types of cancers. Here, the authors perform genome-wide association studies and characterize pan-cancer heritability and pleiotropy in individuals of European ancestry across 18 cancer types from two large cohorts.Sara R. RashkinRebecca E. GraffLinda KachuriKhanh K. ThaiStacey E. AlexeeffMaruta A. BlatchinsTaylor B. CavazosDouglas A. CorleyNima C. EmamiJoshua D. HoffmanEric JorgensonLawrence H. KushiTravis J. MeyersStephen K. Van Den EedenElad ZivLaurel A. HabelThomas J. HoffmannLori C. SakodaJohn S. WitteNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sara R. Rashkin Rebecca E. Graff Linda Kachuri Khanh K. Thai Stacey E. Alexeeff Maruta A. Blatchins Taylor B. Cavazos Douglas A. Corley Nima C. Emami Joshua D. Hoffman Eric Jorgenson Lawrence H. Kushi Travis J. Meyers Stephen K. Van Den Eeden Elad Ziv Laurel A. Habel Thomas J. Hoffmann Lori C. Sakoda John S. Witte Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts
description	Pleiotropic loci and genome-wide genetic correlations have identified shared heritability across some types of cancers. Here, the authors perform genome-wide association studies and characterize pan-cancer heritability and pleiotropy in individuals of European ancestry across 18 cancer types from two large cohorts.
format	article
author	Sara R. Rashkin Rebecca E. Graff Linda Kachuri Khanh K. Thai Stacey E. Alexeeff Maruta A. Blatchins Taylor B. Cavazos Douglas A. Corley Nima C. Emami Joshua D. Hoffman Eric Jorgenson Lawrence H. Kushi Travis J. Meyers Stephen K. Van Den Eeden Elad Ziv Laurel A. Habel Thomas J. Hoffmann Lori C. Sakoda John S. Witte
author_facet	Sara R. Rashkin Rebecca E. Graff Linda Kachuri Khanh K. Thai Stacey E. Alexeeff Maruta A. Blatchins Taylor B. Cavazos Douglas A. Corley Nima C. Emami Joshua D. Hoffman Eric Jorgenson Lawrence H. Kushi Travis J. Meyers Stephen K. Van Den Eeden Elad Ziv Laurel A. Habel Thomas J. Hoffmann Lori C. Sakoda John S. Witte
author_sort	Sara R. Rashkin
title	Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts
title_short	Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts
title_full	Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts
title_fullStr	Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts
title_full_unstemmed	Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts
title_sort	pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/45eda6708b934235846a8a794af520d2
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Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts

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