Imaging Protocol, Feasibility, and Reproducibility of Cardiovascular Phenotyping in a Large Tri-Ethnic Population-Based Study of Older People: The Southall and Brent Revisited (SABRE) Study
Background: People of South Asian and African Caribbean ethnicities living in UK have a high risk of cardiometabolic disease. Limited data exist regarding detailed cardiometabolic phenotyping in this population. Methods enabling this are widely available, but the practical aspects of undertaking suc...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Frontiers Media S.A.
2020
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/45ee274e872b47508455123024b5e8be |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:45ee274e872b47508455123024b5e8be |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:45ee274e872b47508455123024b5e8be2021-11-04T14:30:47ZImaging Protocol, Feasibility, and Reproducibility of Cardiovascular Phenotyping in a Large Tri-Ethnic Population-Based Study of Older People: The Southall and Brent Revisited (SABRE) Study2297-055X10.3389/fcvm.2020.591946https://doaj.org/article/45ee274e872b47508455123024b5e8be2020-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2020.591946/fullhttps://doaj.org/toc/2297-055XBackground: People of South Asian and African Caribbean ethnicities living in UK have a high risk of cardiometabolic disease. Limited data exist regarding detailed cardiometabolic phenotyping in this population. Methods enabling this are widely available, but the practical aspects of undertaking such studies in large and diverse samples are seldom reported.Methods: The Southall and Brent Revisited (SABRE) study is the UK's largest tri-ethnic longitudinal cohort. Over 1,400 surviving participants (58–85 years) attended the 2nd study visit (2008–2011); during which, comprehensive cardiovascular phenotyping, including 3D-echocardiography [3D-speckle-tracking (3D-STE)], computed tomography, coronary artery calcium scoring, pulse wave velocity, central blood pressure, carotid artery ultrasound, and retinal imaging, were performed. We describe the methods used with the aim of providing a guide to their feasibility and reproducibility in a large tri-ethnic population-based study of older people.Results: Conventional echocardiography and all vascular measurements showed high feasibility (>90% analyzable of clinic attendees), but 3D-echocardiography (3DE) and 3D-STE were less feasible (71% 3DE acquisition feasibility and 38% 3D-STE feasibility of clinic attendees). 3D-STE feasibility differed by ethnicity, being lowest in South Asian participants and highest in African Caribbean participants (p < 0.0001). Similar trends were observed in men (P < 0.0001) and women (P = 0.005); however, in South Asians, there were more women with unreadable 3D-images compared to men (67 vs. 58%). Intra- and inter-observer variabilities were excellent for most of conventional and advanced echocardiographic measures. The test-retest reproducibility was good-excellent and fair-good for conventional and advanced echocardiographic measures, respectively, but lower than when re-reading the same images. All vascular measures demonstrated excellent or fair-good reproducibility.Conclusions: We describe the feasibility and reproducibility of detailed cardiovascular phenotyping in an ethnically diverse population. The data collected will lead to a better understanding of why people of South Asian and African Caribbean ancestry are at elevated risk of cardiometabolic diseases.Lamia Al SaikhanMuath AlobaidaMuath AlobaidaAnish BhuvaNish ChaturvediJohn HeasmanAlun D. HughesSiana JonesSophie EastwoodCharlotte ManistyKatherine MarchArjun K. GhoshArjun K. GhoshArjun K. GhoshJamil MayetAyodipupo OguntadeTherese TillinSuzanne WilliamsAndrew WrightChloe ParkFrontiers Media S.A.articlepopulation-basedcardiovascularimagingechocardiographyvascularfeasibilityDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 7 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
population-based cardiovascular imaging echocardiography vascular feasibility Diseases of the circulatory (Cardiovascular) system RC666-701 |
| spellingShingle |
population-based cardiovascular imaging echocardiography vascular feasibility Diseases of the circulatory (Cardiovascular) system RC666-701 Lamia Al Saikhan Muath Alobaida Muath Alobaida Anish Bhuva Nish Chaturvedi John Heasman Alun D. Hughes Siana Jones Sophie Eastwood Charlotte Manisty Katherine March Arjun K. Ghosh Arjun K. Ghosh Arjun K. Ghosh Jamil Mayet Ayodipupo Oguntade Therese Tillin Suzanne Williams Andrew Wright Chloe Park Imaging Protocol, Feasibility, and Reproducibility of Cardiovascular Phenotyping in a Large Tri-Ethnic Population-Based Study of Older People: The Southall and Brent Revisited (SABRE) Study |
| description |
Background: People of South Asian and African Caribbean ethnicities living in UK have a high risk of cardiometabolic disease. Limited data exist regarding detailed cardiometabolic phenotyping in this population. Methods enabling this are widely available, but the practical aspects of undertaking such studies in large and diverse samples are seldom reported.Methods: The Southall and Brent Revisited (SABRE) study is the UK's largest tri-ethnic longitudinal cohort. Over 1,400 surviving participants (58–85 years) attended the 2nd study visit (2008–2011); during which, comprehensive cardiovascular phenotyping, including 3D-echocardiography [3D-speckle-tracking (3D-STE)], computed tomography, coronary artery calcium scoring, pulse wave velocity, central blood pressure, carotid artery ultrasound, and retinal imaging, were performed. We describe the methods used with the aim of providing a guide to their feasibility and reproducibility in a large tri-ethnic population-based study of older people.Results: Conventional echocardiography and all vascular measurements showed high feasibility (>90% analyzable of clinic attendees), but 3D-echocardiography (3DE) and 3D-STE were less feasible (71% 3DE acquisition feasibility and 38% 3D-STE feasibility of clinic attendees). 3D-STE feasibility differed by ethnicity, being lowest in South Asian participants and highest in African Caribbean participants (p < 0.0001). Similar trends were observed in men (P < 0.0001) and women (P = 0.005); however, in South Asians, there were more women with unreadable 3D-images compared to men (67 vs. 58%). Intra- and inter-observer variabilities were excellent for most of conventional and advanced echocardiographic measures. The test-retest reproducibility was good-excellent and fair-good for conventional and advanced echocardiographic measures, respectively, but lower than when re-reading the same images. All vascular measures demonstrated excellent or fair-good reproducibility.Conclusions: We describe the feasibility and reproducibility of detailed cardiovascular phenotyping in an ethnically diverse population. The data collected will lead to a better understanding of why people of South Asian and African Caribbean ancestry are at elevated risk of cardiometabolic diseases. |
| format |
article |
| author |
Lamia Al Saikhan Muath Alobaida Muath Alobaida Anish Bhuva Nish Chaturvedi John Heasman Alun D. Hughes Siana Jones Sophie Eastwood Charlotte Manisty Katherine March Arjun K. Ghosh Arjun K. Ghosh Arjun K. Ghosh Jamil Mayet Ayodipupo Oguntade Therese Tillin Suzanne Williams Andrew Wright Chloe Park |
| author_facet |
Lamia Al Saikhan Muath Alobaida Muath Alobaida Anish Bhuva Nish Chaturvedi John Heasman Alun D. Hughes Siana Jones Sophie Eastwood Charlotte Manisty Katherine March Arjun K. Ghosh Arjun K. Ghosh Arjun K. Ghosh Jamil Mayet Ayodipupo Oguntade Therese Tillin Suzanne Williams Andrew Wright Chloe Park |
| author_sort |
Lamia Al Saikhan |
| title |
Imaging Protocol, Feasibility, and Reproducibility of Cardiovascular Phenotyping in a Large Tri-Ethnic Population-Based Study of Older People: The Southall and Brent Revisited (SABRE) Study |
| title_short |
Imaging Protocol, Feasibility, and Reproducibility of Cardiovascular Phenotyping in a Large Tri-Ethnic Population-Based Study of Older People: The Southall and Brent Revisited (SABRE) Study |
| title_full |
Imaging Protocol, Feasibility, and Reproducibility of Cardiovascular Phenotyping in a Large Tri-Ethnic Population-Based Study of Older People: The Southall and Brent Revisited (SABRE) Study |
| title_fullStr |
Imaging Protocol, Feasibility, and Reproducibility of Cardiovascular Phenotyping in a Large Tri-Ethnic Population-Based Study of Older People: The Southall and Brent Revisited (SABRE) Study |
| title_full_unstemmed |
Imaging Protocol, Feasibility, and Reproducibility of Cardiovascular Phenotyping in a Large Tri-Ethnic Population-Based Study of Older People: The Southall and Brent Revisited (SABRE) Study |
| title_sort |
imaging protocol, feasibility, and reproducibility of cardiovascular phenotyping in a large tri-ethnic population-based study of older people: the southall and brent revisited (sabre) study |
| publisher |
Frontiers Media S.A. |
| publishDate |
2020 |
| url |
https://doaj.org/article/45ee274e872b47508455123024b5e8be |
| work_keys_str_mv |
AT lamiaalsaikhan imagingprotocolfeasibilityandreproducibilityofcardiovascularphenotypinginalargetriethnicpopulationbasedstudyofolderpeoplethesouthallandbrentrevisitedsabrestudy AT muathalobaida imagingprotocolfeasibilityandreproducibilityofcardiovascularphenotypinginalargetriethnicpopulationbasedstudyofolderpeoplethesouthallandbrentrevisitedsabrestudy AT muathalobaida imagingprotocolfeasibilityandreproducibilityofcardiovascularphenotypinginalargetriethnicpopulationbasedstudyofolderpeoplethesouthallandbrentrevisitedsabrestudy AT anishbhuva imagingprotocolfeasibilityandreproducibilityofcardiovascularphenotypinginalargetriethnicpopulationbasedstudyofolderpeoplethesouthallandbrentrevisitedsabrestudy AT nishchaturvedi imagingprotocolfeasibilityandreproducibilityofcardiovascularphenotypinginalargetriethnicpopulationbasedstudyofolderpeoplethesouthallandbrentrevisitedsabrestudy AT johnheasman imagingprotocolfeasibilityandreproducibilityofcardiovascularphenotypinginalargetriethnicpopulationbasedstudyofolderpeoplethesouthallandbrentrevisitedsabrestudy AT alundhughes imagingprotocolfeasibilityandreproducibilityofcardiovascularphenotypinginalargetriethnicpopulationbasedstudyofolderpeoplethesouthallandbrentrevisitedsabrestudy AT sianajones imagingprotocolfeasibilityandreproducibilityofcardiovascularphenotypinginalargetriethnicpopulationbasedstudyofolderpeoplethesouthallandbrentrevisitedsabrestudy AT sophieeastwood imagingprotocolfeasibilityandreproducibilityofcardiovascularphenotypinginalargetriethnicpopulationbasedstudyofolderpeoplethesouthallandbrentrevisitedsabrestudy AT charlottemanisty imagingprotocolfeasibilityandreproducibilityofcardiovascularphenotypinginalargetriethnicpopulationbasedstudyofolderpeoplethesouthallandbrentrevisitedsabrestudy AT katherinemarch imagingprotocolfeasibilityandreproducibilityofcardiovascularphenotypinginalargetriethnicpopulationbasedstudyofolderpeoplethesouthallandbrentrevisitedsabrestudy AT arjunkghosh imagingprotocolfeasibilityandreproducibilityofcardiovascularphenotypinginalargetriethnicpopulationbasedstudyofolderpeoplethesouthallandbrentrevisitedsabrestudy AT arjunkghosh imagingprotocolfeasibilityandreproducibilityofcardiovascularphenotypinginalargetriethnicpopulationbasedstudyofolderpeoplethesouthallandbrentrevisitedsabrestudy AT arjunkghosh imagingprotocolfeasibilityandreproducibilityofcardiovascularphenotypinginalargetriethnicpopulationbasedstudyofolderpeoplethesouthallandbrentrevisitedsabrestudy AT jamilmayet imagingprotocolfeasibilityandreproducibilityofcardiovascularphenotypinginalargetriethnicpopulationbasedstudyofolderpeoplethesouthallandbrentrevisitedsabrestudy AT ayodipupooguntade imagingprotocolfeasibilityandreproducibilityofcardiovascularphenotypinginalargetriethnicpopulationbasedstudyofolderpeoplethesouthallandbrentrevisitedsabrestudy AT theresetillin imagingprotocolfeasibilityandreproducibilityofcardiovascularphenotypinginalargetriethnicpopulationbasedstudyofolderpeoplethesouthallandbrentrevisitedsabrestudy AT suzannewilliams imagingprotocolfeasibilityandreproducibilityofcardiovascularphenotypinginalargetriethnicpopulationbasedstudyofolderpeoplethesouthallandbrentrevisitedsabrestudy AT andrewwright imagingprotocolfeasibilityandreproducibilityofcardiovascularphenotypinginalargetriethnicpopulationbasedstudyofolderpeoplethesouthallandbrentrevisitedsabrestudy AT chloepark imagingprotocolfeasibilityandreproducibilityofcardiovascularphenotypinginalargetriethnicpopulationbasedstudyofolderpeoplethesouthallandbrentrevisitedsabrestudy |
| _version_ |
1718444834670247936 |