Microtubules orchestrate local translation to enable cardiac growth

New contractile units are required during cardiac hypertrophy, though it remains unclear precisely where and how these new sarcomeres are added. Here the authors reveal that in the heart, microtubules spatiotemporally regulate mRNAs and ribosomes to build new sarcomeres, a role which is essential fo...

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Autores principales: Emily A. Scarborough, Keita Uchida, Maria Vogel, Noa Erlitzki, Meghana Iyer, Sai Aung Phyo, Alexey Bogush, Izhak Kehat, Benjamin L. Prosser
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/45f029fcfdd34855a349043120951555
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Sumario:New contractile units are required during cardiac hypertrophy, though it remains unclear precisely where and how these new sarcomeres are added. Here the authors reveal that in the heart, microtubules spatiotemporally regulate mRNAs and ribosomes to build new sarcomeres, a role which is essential for growth.