Microtubules orchestrate local translation to enable cardiac growth

New contractile units are required during cardiac hypertrophy, though it remains unclear precisely where and how these new sarcomeres are added. Here the authors reveal that in the heart, microtubules spatiotemporally regulate mRNAs and ribosomes to build new sarcomeres, a role which is essential fo...

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Autores principales:	Emily A. Scarborough, Keita Uchida, Maria Vogel, Noa Erlitzki, Meghana Iyer, Sai Aung Phyo, Alexey Bogush, Izhak Kehat, Benjamin L. Prosser
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/45f029fcfdd34855a349043120951555
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spelling	oai:doaj.org-article:45f029fcfdd34855a3490431209515552021-12-02T15:53:26ZMicrotubules orchestrate local translation to enable cardiac growth10.1038/s41467-021-21685-42041-1723https://doaj.org/article/45f029fcfdd34855a3490431209515552021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21685-4https://doaj.org/toc/2041-1723New contractile units are required during cardiac hypertrophy, though it remains unclear precisely where and how these new sarcomeres are added. Here the authors reveal that in the heart, microtubules spatiotemporally regulate mRNAs and ribosomes to build new sarcomeres, a role which is essential for growth.Emily A. ScarboroughKeita UchidaMaria VogelNoa ErlitzkiMeghana IyerSai Aung PhyoAlexey BogushIzhak KehatBenjamin L. ProsserNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Emily A. Scarborough Keita Uchida Maria Vogel Noa Erlitzki Meghana Iyer Sai Aung Phyo Alexey Bogush Izhak Kehat Benjamin L. Prosser Microtubules orchestrate local translation to enable cardiac growth
description	New contractile units are required during cardiac hypertrophy, though it remains unclear precisely where and how these new sarcomeres are added. Here the authors reveal that in the heart, microtubules spatiotemporally regulate mRNAs and ribosomes to build new sarcomeres, a role which is essential for growth.
format	article
author	Emily A. Scarborough Keita Uchida Maria Vogel Noa Erlitzki Meghana Iyer Sai Aung Phyo Alexey Bogush Izhak Kehat Benjamin L. Prosser
author_facet	Emily A. Scarborough Keita Uchida Maria Vogel Noa Erlitzki Meghana Iyer Sai Aung Phyo Alexey Bogush Izhak Kehat Benjamin L. Prosser
author_sort	Emily A. Scarborough
title	Microtubules orchestrate local translation to enable cardiac growth
title_short	Microtubules orchestrate local translation to enable cardiac growth
title_full	Microtubules orchestrate local translation to enable cardiac growth
title_fullStr	Microtubules orchestrate local translation to enable cardiac growth
title_full_unstemmed	Microtubules orchestrate local translation to enable cardiac growth
title_sort	microtubules orchestrate local translation to enable cardiac growth
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/45f029fcfdd34855a349043120951555
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Microtubules orchestrate local translation to enable cardiac growth

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