Tobamoviruses can be frequently present in the oropharynx and gut of infants during their first year of life
Abstract Plant viruses have been reported to be common in the gut of human adults, presumably as result of food ingestion. In this work, we report that plant viruses can also be found frequently in the gut and oropharynx of children during their first year of life, even when they are exclusively bre...
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2020
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oai:doaj.org-article:45f8b8eead0746a19898b7d622e0c5282021-12-02T16:43:42ZTobamoviruses can be frequently present in the oropharynx and gut of infants during their first year of life10.1038/s41598-020-70684-w2045-2322https://doaj.org/article/45f8b8eead0746a19898b7d622e0c5282020-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-70684-whttps://doaj.org/toc/2045-2322Abstract Plant viruses have been reported to be common in the gut of human adults, presumably as result of food ingestion. In this work, we report that plant viruses can also be found frequently in the gut and oropharynx of children during their first year of life, even when they are exclusively breast-fed. Fecal and oropharynx samples were collected monthly, from birth to 1 year of age, from three apparently healthy children in a semi-rural community and analyzed by next generation sequencing. In 100% of the fecal samples and 65% of the oropharynx samples at least one plant virus was identified. Tobamoviruses in the Virgaviridae family were by far the most frequently detected, with tropical soda apple mosaic virus, pepper mild mottle virus, and opuntia tobamovirus 2 being the most common species. Seventeen complete virus genomes could be assembled, and phylogenetic analyses showed a large diversity of virus strains circulating in the population. These results suggest that children are continuously exposed to an extensive and highly diverse collection of tobamoviruses. Whether the common presence of plant viruses at an early age influences the infant’s immune system, either directly or through interaction with other members of the microbiota, remains to be investigated.Yarenci Aguado-GarcíaBlanca TaboadaPatricia MoránXaira Rivera-GutiérrezAngélica Serrano-VázquezPavel IšaLiliana Rojas-VelázquezHoracio Pérez-JuárezSusana LópezJavier TorresCecilia XiménezCarlos F. AriasNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-11 (2020) |
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| topic |
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Medicine R Science Q Yarenci Aguado-García Blanca Taboada Patricia Morán Xaira Rivera-Gutiérrez Angélica Serrano-Vázquez Pavel Iša Liliana Rojas-Velázquez Horacio Pérez-Juárez Susana López Javier Torres Cecilia Ximénez Carlos F. Arias Tobamoviruses can be frequently present in the oropharynx and gut of infants during their first year of life |
| description |
Abstract Plant viruses have been reported to be common in the gut of human adults, presumably as result of food ingestion. In this work, we report that plant viruses can also be found frequently in the gut and oropharynx of children during their first year of life, even when they are exclusively breast-fed. Fecal and oropharynx samples were collected monthly, from birth to 1 year of age, from three apparently healthy children in a semi-rural community and analyzed by next generation sequencing. In 100% of the fecal samples and 65% of the oropharynx samples at least one plant virus was identified. Tobamoviruses in the Virgaviridae family were by far the most frequently detected, with tropical soda apple mosaic virus, pepper mild mottle virus, and opuntia tobamovirus 2 being the most common species. Seventeen complete virus genomes could be assembled, and phylogenetic analyses showed a large diversity of virus strains circulating in the population. These results suggest that children are continuously exposed to an extensive and highly diverse collection of tobamoviruses. Whether the common presence of plant viruses at an early age influences the infant’s immune system, either directly or through interaction with other members of the microbiota, remains to be investigated. |
| format |
article |
| author |
Yarenci Aguado-García Blanca Taboada Patricia Morán Xaira Rivera-Gutiérrez Angélica Serrano-Vázquez Pavel Iša Liliana Rojas-Velázquez Horacio Pérez-Juárez Susana López Javier Torres Cecilia Ximénez Carlos F. Arias |
| author_facet |
Yarenci Aguado-García Blanca Taboada Patricia Morán Xaira Rivera-Gutiérrez Angélica Serrano-Vázquez Pavel Iša Liliana Rojas-Velázquez Horacio Pérez-Juárez Susana López Javier Torres Cecilia Ximénez Carlos F. Arias |
| author_sort |
Yarenci Aguado-García |
| title |
Tobamoviruses can be frequently present in the oropharynx and gut of infants during their first year of life |
| title_short |
Tobamoviruses can be frequently present in the oropharynx and gut of infants during their first year of life |
| title_full |
Tobamoviruses can be frequently present in the oropharynx and gut of infants during their first year of life |
| title_fullStr |
Tobamoviruses can be frequently present in the oropharynx and gut of infants during their first year of life |
| title_full_unstemmed |
Tobamoviruses can be frequently present in the oropharynx and gut of infants during their first year of life |
| title_sort |
tobamoviruses can be frequently present in the oropharynx and gut of infants during their first year of life |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/45f8b8eead0746a19898b7d622e0c528 |
| work_keys_str_mv |
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| _version_ |
1718383511946133504 |