Increased neural habituation in the amygdala and orbitofrontal cortex in social anxiety disorder revealed by FMRI.

A characterizing symptom of social anxiety disorder (SAD) is increased emotional reactivity towards potential social threat in combination with impaired emotion and stress regulation. While several neuroimaging studies have linked SAD with hyperreactivity in limbic brain regions when exposed to emot...

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Autores principales:	Ronald Sladky, Anna Höflich, Jacqueline Atanelov, Christoph Kraus, Pia Baldinger, Ewald Moser, Rupert Lanzenberger, Christian Windischberger
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/45fd42d1d196432caa352f4ecf0419ab
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spelling	oai:doaj.org-article:45fd42d1d196432caa352f4ecf0419ab2021-11-18T08:07:08ZIncreased neural habituation in the amygdala and orbitofrontal cortex in social anxiety disorder revealed by FMRI.1932-620310.1371/journal.pone.0050050https://doaj.org/article/45fd42d1d196432caa352f4ecf0419ab2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23209643/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203A characterizing symptom of social anxiety disorder (SAD) is increased emotional reactivity towards potential social threat in combination with impaired emotion and stress regulation. While several neuroimaging studies have linked SAD with hyperreactivity in limbic brain regions when exposed to emotional faces, little is known about habituation in both the amygdala and neocortical regulation areas. 15 untreated SAD patients and 15 age- and gender-matched healthy controls underwent functional magnetic resonance imaging during repeated blocks of facial emotion ([Formula: see text]) and object discrimination tasks ([Formula: see text]). Emotion processing networks were defined by a task-related contrast ([Formula: see text]). Linear regression was employed for assessing habituation effects in these regions. In both groups, the employed paradigm robustly activated the emotion processing and regulation network, including the amygdalae and orbitofrontal cortex (OFC). Statistically significant habituation effects were found in the amygdalae, OFC, and pulvinar thalamus of SAD patients. No such habituation was found in healthy controls. Concurrent habituation in the medial OFC and the amygdalae of SAD patients as shown in this study suggests intact functional integrity and successful short-term down-regulation of neural activation in brain areas responsible for emotion processing. Initial hyperactivation may be explained by an insufficient habituation to new stimuli during the first seconds of exposure. In addition, our results highlight the relevance of the orbitofrontal cortex in social anxiety disorders.Ronald SladkyAnna HöflichJacqueline AtanelovChristoph KrausPia BaldingerEwald MoserRupert LanzenbergerChristian WindischbergerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e50050 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ronald Sladky Anna Höflich Jacqueline Atanelov Christoph Kraus Pia Baldinger Ewald Moser Rupert Lanzenberger Christian Windischberger Increased neural habituation in the amygdala and orbitofrontal cortex in social anxiety disorder revealed by FMRI.
description	A characterizing symptom of social anxiety disorder (SAD) is increased emotional reactivity towards potential social threat in combination with impaired emotion and stress regulation. While several neuroimaging studies have linked SAD with hyperreactivity in limbic brain regions when exposed to emotional faces, little is known about habituation in both the amygdala and neocortical regulation areas. 15 untreated SAD patients and 15 age- and gender-matched healthy controls underwent functional magnetic resonance imaging during repeated blocks of facial emotion ([Formula: see text]) and object discrimination tasks ([Formula: see text]). Emotion processing networks were defined by a task-related contrast ([Formula: see text]). Linear regression was employed for assessing habituation effects in these regions. In both groups, the employed paradigm robustly activated the emotion processing and regulation network, including the amygdalae and orbitofrontal cortex (OFC). Statistically significant habituation effects were found in the amygdalae, OFC, and pulvinar thalamus of SAD patients. No such habituation was found in healthy controls. Concurrent habituation in the medial OFC and the amygdalae of SAD patients as shown in this study suggests intact functional integrity and successful short-term down-regulation of neural activation in brain areas responsible for emotion processing. Initial hyperactivation may be explained by an insufficient habituation to new stimuli during the first seconds of exposure. In addition, our results highlight the relevance of the orbitofrontal cortex in social anxiety disorders.
format	article
author	Ronald Sladky Anna Höflich Jacqueline Atanelov Christoph Kraus Pia Baldinger Ewald Moser Rupert Lanzenberger Christian Windischberger
author_facet	Ronald Sladky Anna Höflich Jacqueline Atanelov Christoph Kraus Pia Baldinger Ewald Moser Rupert Lanzenberger Christian Windischberger
author_sort	Ronald Sladky
title	Increased neural habituation in the amygdala and orbitofrontal cortex in social anxiety disorder revealed by FMRI.
title_short	Increased neural habituation in the amygdala and orbitofrontal cortex in social anxiety disorder revealed by FMRI.
title_full	Increased neural habituation in the amygdala and orbitofrontal cortex in social anxiety disorder revealed by FMRI.
title_fullStr	Increased neural habituation in the amygdala and orbitofrontal cortex in social anxiety disorder revealed by FMRI.
title_full_unstemmed	Increased neural habituation in the amygdala and orbitofrontal cortex in social anxiety disorder revealed by FMRI.
title_sort	increased neural habituation in the amygdala and orbitofrontal cortex in social anxiety disorder revealed by fmri.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/45fd42d1d196432caa352f4ecf0419ab
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Increased neural habituation in the amygdala and orbitofrontal cortex in social anxiety disorder revealed by FMRI.

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