Monitoring and management of lung cancer patients following curative-intent treatment: clinical utility of 2-deoxy-2-[fluorine-18]fluoro-d-glucose positron emission tomography/computed tomography

Shigeki Sawada, Hiroshi Suehisa, Tsuyoshi Ueno, Ryujiro Sugimoto, Motohiro Yamashita Department of Thoracic Surgery, National Hospital Organization Shikoku Cancer Center, Matsuyama, Japan Abstract: A large number of studies have demonstrated that 2-deoxy-2-[fluorine-18]fluoro-d-glucose positron emi...

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Autores principales:	Sawada S, Suehisa H, Ueno T, Sugimoto R, Yamashita M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	lung cancer follow-up surveillance 2-deoxy-2-[fluorine-18]fluoro-D-glucose positron emission tomography (FDG-PET) positron emission tomography-computed tomography (PET/CT) Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
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spelling	oai:doaj.org-article:4600742be59040dbaf2c7177623437462021-12-02T05:13:40ZMonitoring and management of lung cancer patients following curative-intent treatment: clinical utility of 2-deoxy-2-[fluorine-18]fluoro-d-glucose positron emission tomography/computed tomography1179-2728https://doaj.org/article/4600742be59040dbaf2c7177623437462016-04-01T00:00:00Zhttps://www.dovepress.com/monitoring-and-management-of-lung-cancer-patients-following-curative-i-peer-reviewed-article-LCTThttps://doaj.org/toc/1179-2728Shigeki Sawada, Hiroshi Suehisa, Tsuyoshi Ueno, Ryujiro Sugimoto, Motohiro Yamashita Department of Thoracic Surgery, National Hospital Organization Shikoku Cancer Center, Matsuyama, Japan Abstract: A large number of studies have demonstrated that 2-deoxy-2-[fluorine-18]fluoro-d-glucose positron emission tomography/computed tomography (FDG-PET/CT) is superior to conventional modalities for the diagnosis of lung cancer and the evaluation of the extent of the disease. However, the efficacy of PET/CT in a follow-up surveillance setting following curative-intent treatments for lung cancer has not yet been established. We reviewed previous papers and evaluated the potential efficacy of PET-CT in the setting of follow-up surveillance. The following are our findings: 1) PET/CT is considered to be superior or equivalent to conventional modalities for the detection of local recurrence. However, inflammatory changes and fibrosis after treatments in local areas often result in false-positive findings; 2) the detection of asymptomatic distant metastasis is considered to be an advantage of PET/CT in a follow-up setting. However, it should be noted that detection of brain metastasis with PET/CT has some limitation, similar to its use in pretreatment staging; 3) additional radiation exposure and higher medical cost arising from the use of PET/CT should be taken into consideration, particularly in patients who might not have cancer after curative-intent treatment and are expected to have a long lifespan. The absence of any data regarding survival benefits and/or improvements in quality of life is another critical issue. In summary, PET/CT is considered to be more accurate and sensitive than conventional modalities for the detection of asymptomatic recurrence after curative-intent treatments. These advantages could modify subsequent management in patients with suspected recurrence and might contribute to the selection of appropriate treatments for recurrence. Therefore, PET/CT may be an alternative to conventional follow-up modalities. However, several important issues remain to be solved. PET/CT in a follow-up surveillance setting is generally not recommended in clinical practice at the moment. Keywords: lung cancer, follow-up surveillance, FDG-PET/CTSawada SSuehisa HUeno TSugimoto RYamashita MDove Medical Pressarticlelung cancerfollow-up surveillance2-deoxy-2-[fluorine-18]fluoro-D-glucose positron emission tomography (FDG-PET)positron emission tomography-computed tomography (PET/CT)Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENLung Cancer: Targets and Therapy, Vol 2016, Iss Issue 1, Pp 45-51 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	lung cancer follow-up surveillance 2-deoxy-2-[fluorine-18]fluoro-D-glucose positron emission tomography (FDG-PET) positron emission tomography-computed tomography (PET/CT) Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	lung cancer follow-up surveillance 2-deoxy-2-[fluorine-18]fluoro-D-glucose positron emission tomography (FDG-PET) positron emission tomography-computed tomography (PET/CT) Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Sawada S Suehisa H Ueno T Sugimoto R Yamashita M Monitoring and management of lung cancer patients following curative-intent treatment: clinical utility of 2-deoxy-2-[fluorine-18]fluoro-d-glucose positron emission tomography/computed tomography
description	Shigeki Sawada, Hiroshi Suehisa, Tsuyoshi Ueno, Ryujiro Sugimoto, Motohiro Yamashita Department of Thoracic Surgery, National Hospital Organization Shikoku Cancer Center, Matsuyama, Japan Abstract: A large number of studies have demonstrated that 2-deoxy-2-[fluorine-18]fluoro-d-glucose positron emission tomography/computed tomography (FDG-PET/CT) is superior to conventional modalities for the diagnosis of lung cancer and the evaluation of the extent of the disease. However, the efficacy of PET/CT in a follow-up surveillance setting following curative-intent treatments for lung cancer has not yet been established. We reviewed previous papers and evaluated the potential efficacy of PET-CT in the setting of follow-up surveillance. The following are our findings: 1) PET/CT is considered to be superior or equivalent to conventional modalities for the detection of local recurrence. However, inflammatory changes and fibrosis after treatments in local areas often result in false-positive findings; 2) the detection of asymptomatic distant metastasis is considered to be an advantage of PET/CT in a follow-up setting. However, it should be noted that detection of brain metastasis with PET/CT has some limitation, similar to its use in pretreatment staging; 3) additional radiation exposure and higher medical cost arising from the use of PET/CT should be taken into consideration, particularly in patients who might not have cancer after curative-intent treatment and are expected to have a long lifespan. The absence of any data regarding survival benefits and/or improvements in quality of life is another critical issue. In summary, PET/CT is considered to be more accurate and sensitive than conventional modalities for the detection of asymptomatic recurrence after curative-intent treatments. These advantages could modify subsequent management in patients with suspected recurrence and might contribute to the selection of appropriate treatments for recurrence. Therefore, PET/CT may be an alternative to conventional follow-up modalities. However, several important issues remain to be solved. PET/CT in a follow-up surveillance setting is generally not recommended in clinical practice at the moment. Keywords: lung cancer, follow-up surveillance, FDG-PET/CT
format	article
author	Sawada S Suehisa H Ueno T Sugimoto R Yamashita M
author_facet	Sawada S Suehisa H Ueno T Sugimoto R Yamashita M
author_sort	Sawada S
title	Monitoring and management of lung cancer patients following curative-intent treatment: clinical utility of 2-deoxy-2-[fluorine-18]fluoro-d-glucose positron emission tomography/computed tomography
title_short	Monitoring and management of lung cancer patients following curative-intent treatment: clinical utility of 2-deoxy-2-[fluorine-18]fluoro-d-glucose positron emission tomography/computed tomography
title_full	Monitoring and management of lung cancer patients following curative-intent treatment: clinical utility of 2-deoxy-2-[fluorine-18]fluoro-d-glucose positron emission tomography/computed tomography
title_fullStr	Monitoring and management of lung cancer patients following curative-intent treatment: clinical utility of 2-deoxy-2-[fluorine-18]fluoro-d-glucose positron emission tomography/computed tomography
title_full_unstemmed	Monitoring and management of lung cancer patients following curative-intent treatment: clinical utility of 2-deoxy-2-[fluorine-18]fluoro-d-glucose positron emission tomography/computed tomography
title_sort	monitoring and management of lung cancer patients following curative-intent treatment: clinical utility of 2-deoxy-2-[fluorine-18]fluoro-d-glucose positron emission tomography/computed tomography
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/4600742be59040dbaf2c717762343746
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Monitoring and management of lung cancer patients following curative-intent treatment: clinical utility of 2-deoxy-2-[fluorine-18]fluoro-d-glucose positron emission tomography/computed tomography

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