Genomic and molecular features distinguish young adult cancer from later-onset cancer

Summary: Young adult cancer has increased in incidence worldwide, but its molecular etiologies remain unclear. We systematically characterize genomic profiles of young adult tumors with ages of onset ≤50 years and compare them to later-onset tumors using over 6,000 cases across 14 cancer types. Whil...

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Autores principales:	William Lee, Zishan Wang, Miriam Saffern, Tomi Jun, Kuan-lin Huang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	young adult cancer early-onset cancer somatic mutation copy-number variation DNA methylation gene fusion Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/4600d91da5f646a389cc540603e6c427
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spelling	oai:doaj.org-article:4600d91da5f646a389cc540603e6c4272021-11-18T04:47:53ZGenomic and molecular features distinguish young adult cancer from later-onset cancer2211-124710.1016/j.celrep.2021.110005https://doaj.org/article/4600d91da5f646a389cc540603e6c4272021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2211124721014832https://doaj.org/toc/2211-1247Summary: Young adult cancer has increased in incidence worldwide, but its molecular etiologies remain unclear. We systematically characterize genomic profiles of young adult tumors with ages of onset ≤50 years and compare them to later-onset tumors using over 6,000 cases across 14 cancer types. While young adult tumors generally show lower mutation burdens and comparable copy-number variation rates compared to later-onset cases, they are enriched for multiple driver mutations and copy-number alterations in subtype-specific contexts. Characterization of tumor immune microenvironments reveals pan-cancer patterns of elevated TGF-β response/dendritic cells and lower IFN-γ response/macrophages relative to later-onset tumors, corresponding to age-related responses to immunotherapy in several cancer types. Finally, we identify prevalent clinically actionable events that disproportionally affect young adult or later-onset cases. The resulting catalog of age-related molecular drivers can guide precision diagnostics and treatments for young adult cancer.William LeeZishan WangMiriam SaffernTomi JunKuan-lin HuangElsevierarticleyoung adult cancerearly-onset cancersomatic mutationcopy-number variationDNA methylationgene fusionBiology (General)QH301-705.5ENCell Reports, Vol 37, Iss 7, Pp 110005- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	young adult cancer early-onset cancer somatic mutation copy-number variation DNA methylation gene fusion Biology (General) QH301-705.5
spellingShingle	young adult cancer early-onset cancer somatic mutation copy-number variation DNA methylation gene fusion Biology (General) QH301-705.5 William Lee Zishan Wang Miriam Saffern Tomi Jun Kuan-lin Huang Genomic and molecular features distinguish young adult cancer from later-onset cancer
description	Summary: Young adult cancer has increased in incidence worldwide, but its molecular etiologies remain unclear. We systematically characterize genomic profiles of young adult tumors with ages of onset ≤50 years and compare them to later-onset tumors using over 6,000 cases across 14 cancer types. While young adult tumors generally show lower mutation burdens and comparable copy-number variation rates compared to later-onset cases, they are enriched for multiple driver mutations and copy-number alterations in subtype-specific contexts. Characterization of tumor immune microenvironments reveals pan-cancer patterns of elevated TGF-β response/dendritic cells and lower IFN-γ response/macrophages relative to later-onset tumors, corresponding to age-related responses to immunotherapy in several cancer types. Finally, we identify prevalent clinically actionable events that disproportionally affect young adult or later-onset cases. The resulting catalog of age-related molecular drivers can guide precision diagnostics and treatments for young adult cancer.
format	article
author	William Lee Zishan Wang Miriam Saffern Tomi Jun Kuan-lin Huang
author_facet	William Lee Zishan Wang Miriam Saffern Tomi Jun Kuan-lin Huang
author_sort	William Lee
title	Genomic and molecular features distinguish young adult cancer from later-onset cancer
title_short	Genomic and molecular features distinguish young adult cancer from later-onset cancer
title_full	Genomic and molecular features distinguish young adult cancer from later-onset cancer
title_fullStr	Genomic and molecular features distinguish young adult cancer from later-onset cancer
title_full_unstemmed	Genomic and molecular features distinguish young adult cancer from later-onset cancer
title_sort	genomic and molecular features distinguish young adult cancer from later-onset cancer
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/4600d91da5f646a389cc540603e6c427
work_keys_str_mv	AT williamlee genomicandmolecularfeaturesdistinguishyoungadultcancerfromlateronsetcancer AT zishanwang genomicandmolecularfeaturesdistinguishyoungadultcancerfromlateronsetcancer AT miriamsaffern genomicandmolecularfeaturesdistinguishyoungadultcancerfromlateronsetcancer AT tomijun genomicandmolecularfeaturesdistinguishyoungadultcancerfromlateronsetcancer AT kuanlinhuang genomicandmolecularfeaturesdistinguishyoungadultcancerfromlateronsetcancer
_version_	1718425036559220736

Genomic and molecular features distinguish young adult cancer from later-onset cancer

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