Bioactive Compounds from Zingiber montanum and Their Pharmacological Activities with Focus on Zerumbone

The genus Zingiber consists of about 85 species and many of these species are used as food, spices, and medicines. One of the species, Zingiber montanum (J. Koenig) Link ex A. Dietr. is native to Southeast Asia and has been extensively used as traditional medici...

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Autores principales:	Hari Prasad Devkota, Keshav Raj Paudel, Md. Mahadi Hassan, Amina Ibrahim Dirar, Niranjan Das, Anjana Adhikari-Devkota, Javier Echeverría, Rajan Logesh, Niraj Kumar Jha, Sachin Kumar Singh, Philip M. Hansbro, Yinghan Chan, Dinesh Kumar Chellappan, Kamal Dua
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Zingiber montanum</i> <i>Zingiber cassumunar</i> zerumbone anticancer anti-inflammatory Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/46054e81c7204b49972e18c15ba6321f
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spelling	oai:doaj.org-article:46054e81c7204b49972e18c15ba6321f2021-11-11T15:15:38ZBioactive Compounds from <i>Zingiber montanum</i> and Their Pharmacological Activities with Focus on Zerumbone10.3390/app1121102052076-3417https://doaj.org/article/46054e81c7204b49972e18c15ba6321f2021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/21/10205https://doaj.org/toc/2076-3417The genus <i>Zingiber</i> consists of about 85 species and many of these species are used as food, spices, and medicines. One of the species, <i>Zingiber montanum</i> (J. Koenig) Link ex A. Dietr. is native to Southeast Asia and has been extensively used as traditional medicines and food. The aim of this review was to collect and critically analyze the scientific information about the bioactive compounds and pharmacological activities of <i>Z. montanum</i> with focus on one of the main components, zerumbone (ZER). Various studies have reported the analysis of volatile constituents of the essential oils from <i>Z. montanum</i>. Similarly, many phenylbutanoids, flavonoids and terpenes were also isolated from rhizomes. These essential oils, extracts and compounds showed potent antimicrobial, anti-inflammatory and antioxidant activities among others. Zerumbone has been studied widely for its anticancer, anti-inflammatory, and other pharmacological activities. Future studies should focus on the exploration of various pharmacological activities of other compounds including phenylbutanoids and flavonoids. Bioassay guided isolation may result in the separation of other active components from the extracts. <i>Z. montanum</i> could be a promising source for the development of pharmaceutical products and functional foods.Hari Prasad DevkotaKeshav Raj PaudelMd. Mahadi HassanAmina Ibrahim DirarNiranjan DasAnjana Adhikari-DevkotaJavier EcheverríaRajan LogeshNiraj Kumar JhaSachin Kumar SinghPhilip M. HansbroYinghan ChanDinesh Kumar ChellappanKamal DuaMDPI AGarticle<i>Zingiber montanum</i><i>Zingiber cassumunar</i>zerumboneanticanceranti-inflammatoryTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 10205, p 10205 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Zingiber montanum</i> <i>Zingiber cassumunar</i> zerumbone anticancer anti-inflammatory Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	<i>Zingiber montanum</i> <i>Zingiber cassumunar</i> zerumbone anticancer anti-inflammatory Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Hari Prasad Devkota Keshav Raj Paudel Md. Mahadi Hassan Amina Ibrahim Dirar Niranjan Das Anjana Adhikari-Devkota Javier Echeverría Rajan Logesh Niraj Kumar Jha Sachin Kumar Singh Philip M. Hansbro Yinghan Chan Dinesh Kumar Chellappan Kamal Dua Bioactive Compounds from <i>Zingiber montanum</i> and Their Pharmacological Activities with Focus on Zerumbone
description	The genus <i>Zingiber</i> consists of about 85 species and many of these species are used as food, spices, and medicines. One of the species, <i>Zingiber montanum</i> (J. Koenig) Link ex A. Dietr. is native to Southeast Asia and has been extensively used as traditional medicines and food. The aim of this review was to collect and critically analyze the scientific information about the bioactive compounds and pharmacological activities of <i>Z. montanum</i> with focus on one of the main components, zerumbone (ZER). Various studies have reported the analysis of volatile constituents of the essential oils from <i>Z. montanum</i>. Similarly, many phenylbutanoids, flavonoids and terpenes were also isolated from rhizomes. These essential oils, extracts and compounds showed potent antimicrobial, anti-inflammatory and antioxidant activities among others. Zerumbone has been studied widely for its anticancer, anti-inflammatory, and other pharmacological activities. Future studies should focus on the exploration of various pharmacological activities of other compounds including phenylbutanoids and flavonoids. Bioassay guided isolation may result in the separation of other active components from the extracts. <i>Z. montanum</i> could be a promising source for the development of pharmaceutical products and functional foods.
format	article
author	Hari Prasad Devkota Keshav Raj Paudel Md. Mahadi Hassan Amina Ibrahim Dirar Niranjan Das Anjana Adhikari-Devkota Javier Echeverría Rajan Logesh Niraj Kumar Jha Sachin Kumar Singh Philip M. Hansbro Yinghan Chan Dinesh Kumar Chellappan Kamal Dua
author_facet	Hari Prasad Devkota Keshav Raj Paudel Md. Mahadi Hassan Amina Ibrahim Dirar Niranjan Das Anjana Adhikari-Devkota Javier Echeverría Rajan Logesh Niraj Kumar Jha Sachin Kumar Singh Philip M. Hansbro Yinghan Chan Dinesh Kumar Chellappan Kamal Dua
author_sort	Hari Prasad Devkota
title	Bioactive Compounds from <i>Zingiber montanum</i> and Their Pharmacological Activities with Focus on Zerumbone
title_short	Bioactive Compounds from <i>Zingiber montanum</i> and Their Pharmacological Activities with Focus on Zerumbone
title_full	Bioactive Compounds from <i>Zingiber montanum</i> and Their Pharmacological Activities with Focus on Zerumbone
title_fullStr	Bioactive Compounds from <i>Zingiber montanum</i> and Their Pharmacological Activities with Focus on Zerumbone
title_full_unstemmed	Bioactive Compounds from <i>Zingiber montanum</i> and Their Pharmacological Activities with Focus on Zerumbone
title_sort	bioactive compounds from <i>zingiber montanum</i> and their pharmacological activities with focus on zerumbone
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/46054e81c7204b49972e18c15ba6321f
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Bioactive Compounds from <i>Zingiber montanum</i> and Their Pharmacological Activities with Focus on Zerumbone

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