Astrocytes monitor cerebral perfusion and control systemic circulation to maintain brain blood flow

The brain receives 20% of cardiac output, but in accord with the current knowledge lacks a specialized sensor of its own blood flow. Here, the authors show that brain astrocytes detect drops in perfusion and trigger compensatory increases in arterial pressure and heart rate to preserve brain blood f...

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Autores principales:	Nephtali Marina, Isabel N. Christie, Alla Korsak, Maxim Doronin, Alexey Brazhe, Patrick S. Hosford, Jack A. Wells, Shahriar Sheikhbahaei, Ibrahim Humoud, Julian F. R. Paton, Mark F. Lythgoe, Alexey Semyanov, Sergey Kasparov, Alexander V. Gourine
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/460633936e6841f2ab72308399796298
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spelling	oai:doaj.org-article:460633936e6841f2ab723083997962982021-12-02T14:40:52ZAstrocytes monitor cerebral perfusion and control systemic circulation to maintain brain blood flow10.1038/s41467-019-13956-y2041-1723https://doaj.org/article/460633936e6841f2ab723083997962982020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13956-yhttps://doaj.org/toc/2041-1723The brain receives 20% of cardiac output, but in accord with the current knowledge lacks a specialized sensor of its own blood flow. Here, the authors show that brain astrocytes detect drops in perfusion and trigger compensatory increases in arterial pressure and heart rate to preserve brain blood flow and oxygen delivery.Nephtali MarinaIsabel N. ChristieAlla KorsakMaxim DoroninAlexey BrazhePatrick S. HosfordJack A. WellsShahriar SheikhbahaeiIbrahim HumoudJulian F. R. PatonMark F. LythgoeAlexey SemyanovSergey KasparovAlexander V. GourineNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nephtali Marina Isabel N. Christie Alla Korsak Maxim Doronin Alexey Brazhe Patrick S. Hosford Jack A. Wells Shahriar Sheikhbahaei Ibrahim Humoud Julian F. R. Paton Mark F. Lythgoe Alexey Semyanov Sergey Kasparov Alexander V. Gourine Astrocytes monitor cerebral perfusion and control systemic circulation to maintain brain blood flow
description	The brain receives 20% of cardiac output, but in accord with the current knowledge lacks a specialized sensor of its own blood flow. Here, the authors show that brain astrocytes detect drops in perfusion and trigger compensatory increases in arterial pressure and heart rate to preserve brain blood flow and oxygen delivery.
format	article
author	Nephtali Marina Isabel N. Christie Alla Korsak Maxim Doronin Alexey Brazhe Patrick S. Hosford Jack A. Wells Shahriar Sheikhbahaei Ibrahim Humoud Julian F. R. Paton Mark F. Lythgoe Alexey Semyanov Sergey Kasparov Alexander V. Gourine
author_facet	Nephtali Marina Isabel N. Christie Alla Korsak Maxim Doronin Alexey Brazhe Patrick S. Hosford Jack A. Wells Shahriar Sheikhbahaei Ibrahim Humoud Julian F. R. Paton Mark F. Lythgoe Alexey Semyanov Sergey Kasparov Alexander V. Gourine
author_sort	Nephtali Marina
title	Astrocytes monitor cerebral perfusion and control systemic circulation to maintain brain blood flow
title_short	Astrocytes monitor cerebral perfusion and control systemic circulation to maintain brain blood flow
title_full	Astrocytes monitor cerebral perfusion and control systemic circulation to maintain brain blood flow
title_fullStr	Astrocytes monitor cerebral perfusion and control systemic circulation to maintain brain blood flow
title_full_unstemmed	Astrocytes monitor cerebral perfusion and control systemic circulation to maintain brain blood flow
title_sort	astrocytes monitor cerebral perfusion and control systemic circulation to maintain brain blood flow
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/460633936e6841f2ab72308399796298
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Astrocytes monitor cerebral perfusion and control systemic circulation to maintain brain blood flow

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