Role of L-asparaginase in acute lymphoblastic leukemia: focus on adult patients

Michael E RyttingDepartment of Pediatrics and Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USAAbstract: Asparaginase preparations deplete asparagine in acute lymphoblastic leukemia (ALL) blasts. Asparaginase in its various forms is an important component of treatment regimen...

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Autor principal:	Rytting ME
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/46080141dcf442d894e7520d5603e1b7
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spelling	oai:doaj.org-article:46080141dcf442d894e7520d5603e1b72021-12-02T00:39:13ZRole of L-asparaginase in acute lymphoblastic leukemia: focus on adult patients1179-9889https://doaj.org/article/46080141dcf442d894e7520d5603e1b72012-06-01T00:00:00Zhttp://www.dovepress.com/role-of-l-asparaginase-in-acute-lymphoblastic-leukemia-focus-on-adult--a10252https://doaj.org/toc/1179-9889Michael E RyttingDepartment of Pediatrics and Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USAAbstract: Asparaginase preparations deplete asparagine in acute lymphoblastic leukemia (ALL) blasts. Asparaginase in its various forms is an important component of treatment regimens for pediatric ALL. Recently, interest and use of asparaginase in adult patients with ALL has increased, particularly in young adults. There is much less information on asparaginase use and toxicity in adult compared with pediatric populations. This review surveys prior published studies of the three most commonly used asparagine preparations as used in adult patients, and discusses important toxicities encountered in adult patients who receive asparaginase preparations.Keywords: asparaginase, leukemia, adults, childrenRytting MEDove Medical PressarticleDiseases of the blood and blood-forming organsRC633-647.5ENBlood and Lymphatic Cancer: Targets and Therapy, Vol 2012, Iss default, Pp 117-124 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	Diseases of the blood and blood-forming organs RC633-647.5 Rytting ME Role of L-asparaginase in acute lymphoblastic leukemia: focus on adult patients
description	Michael E RyttingDepartment of Pediatrics and Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USAAbstract: Asparaginase preparations deplete asparagine in acute lymphoblastic leukemia (ALL) blasts. Asparaginase in its various forms is an important component of treatment regimens for pediatric ALL. Recently, interest and use of asparaginase in adult patients with ALL has increased, particularly in young adults. There is much less information on asparaginase use and toxicity in adult compared with pediatric populations. This review surveys prior published studies of the three most commonly used asparagine preparations as used in adult patients, and discusses important toxicities encountered in adult patients who receive asparaginase preparations.Keywords: asparaginase, leukemia, adults, children
format	article
author	Rytting ME
author_facet	Rytting ME
author_sort	Rytting ME
title	Role of L-asparaginase in acute lymphoblastic leukemia: focus on adult patients
title_short	Role of L-asparaginase in acute lymphoblastic leukemia: focus on adult patients
title_full	Role of L-asparaginase in acute lymphoblastic leukemia: focus on adult patients
title_fullStr	Role of L-asparaginase in acute lymphoblastic leukemia: focus on adult patients
title_full_unstemmed	Role of L-asparaginase in acute lymphoblastic leukemia: focus on adult patients
title_sort	role of l-asparaginase in acute lymphoblastic leukemia: focus on adult patients
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/46080141dcf442d894e7520d5603e1b7
work_keys_str_mv	AT ryttingme roleoflasparaginaseinacutelymphoblasticleukemiafocusonadultpatients
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Role of L-asparaginase in acute lymphoblastic leukemia: focus on adult patients

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