Antibacterial titanium plate deposited by silver nanoparticles exhibits cell compatibility

Juan Liao1, Mo Anchun1,2, Zhimin Zhu3, Yuan Quan11State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, PR China; 2Department of Dental Implant, 3Department of Prosthodontics; West China Stomatology Hospital, Sichuan University, Chengdu, PR ChinaAbstract: Microbial colonization and bio...

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Autores principales:	Juan Liao, Mo Anchun, Zhimin Zhu, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/460afb253cae4ef8adc8bad5d73760dc
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spelling	oai:doaj.org-article:460afb253cae4ef8adc8bad5d73760dc2021-12-02T08:20:22ZAntibacterial titanium plate deposited by silver nanoparticles exhibits cell compatibility1176-91141178-2013https://doaj.org/article/460afb253cae4ef8adc8bad5d73760dc2010-05-01T00:00:00Zhttp://www.dovepress.com/antibacterial-titanium-plate-deposited-by-silver-nanoparticles-exhibit-a4401https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Juan Liao1, Mo Anchun1,2, Zhimin Zhu3, Yuan Quan11State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, PR China; 2Department of Dental Implant, 3Department of Prosthodontics; West China Stomatology Hospital, Sichuan University, Chengdu, PR ChinaAbstract: Microbial colonization and biofilm formation on the surface of implant devices may cause peri-implantitis and lead to bone loss. The aim of this study was to develop a novel antibacterial titanium implant surface and to test its biological performance. In a previous study, we demonstrated that titanium plates deposited by nanosilver acquired antibacterial activity to Staphylococcus aureus and Escherichia coli. While antibacterial activity is important, biomaterial surfaces should be modified to achieve excellent cell compatibility as well. In the present study, using the MTT assay, fluorescence microscopy, and scanning electron microscopy, we assessed cell viability, cytoskeletal architecture and cell attachment, respectively, on our silver nanoparticle-modified titanium (Ti-nAg) plate. The results demonstrate that the Ti-nAg do not show any cytotoxicity to the human gingival fibroblasts. Our data indicate that Ti-nAg is a novel material with both good antibacterial properties and uncompromised cytocompatibility, which can be used as an implanted biomaterial.Keywords: nanosilver, titanium, antibacterial activity, cytocompatibility Juan LiaoMo AnchunZhimin Zhuet alDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2010, Iss default, Pp 337-342 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Juan Liao Mo Anchun Zhimin Zhu et al Antibacterial titanium plate deposited by silver nanoparticles exhibits cell compatibility
description	Juan Liao1, Mo Anchun1,2, Zhimin Zhu3, Yuan Quan11State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, PR China; 2Department of Dental Implant, 3Department of Prosthodontics; West China Stomatology Hospital, Sichuan University, Chengdu, PR ChinaAbstract: Microbial colonization and biofilm formation on the surface of implant devices may cause peri-implantitis and lead to bone loss. The aim of this study was to develop a novel antibacterial titanium implant surface and to test its biological performance. In a previous study, we demonstrated that titanium plates deposited by nanosilver acquired antibacterial activity to Staphylococcus aureus and Escherichia coli. While antibacterial activity is important, biomaterial surfaces should be modified to achieve excellent cell compatibility as well. In the present study, using the MTT assay, fluorescence microscopy, and scanning electron microscopy, we assessed cell viability, cytoskeletal architecture and cell attachment, respectively, on our silver nanoparticle-modified titanium (Ti-nAg) plate. The results demonstrate that the Ti-nAg do not show any cytotoxicity to the human gingival fibroblasts. Our data indicate that Ti-nAg is a novel material with both good antibacterial properties and uncompromised cytocompatibility, which can be used as an implanted biomaterial.Keywords: nanosilver, titanium, antibacterial activity, cytocompatibility
format	article
author	Juan Liao Mo Anchun Zhimin Zhu et al
author_facet	Juan Liao Mo Anchun Zhimin Zhu et al
author_sort	Juan Liao
title	Antibacterial titanium plate deposited by silver nanoparticles exhibits cell compatibility
title_short	Antibacterial titanium plate deposited by silver nanoparticles exhibits cell compatibility
title_full	Antibacterial titanium plate deposited by silver nanoparticles exhibits cell compatibility
title_fullStr	Antibacterial titanium plate deposited by silver nanoparticles exhibits cell compatibility
title_full_unstemmed	Antibacterial titanium plate deposited by silver nanoparticles exhibits cell compatibility
title_sort	antibacterial titanium plate deposited by silver nanoparticles exhibits cell compatibility
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/460afb253cae4ef8adc8bad5d73760dc
work_keys_str_mv	AT juanliao antibacterialtitaniumplatedepositedbysilvernanoparticlesexhibitscellcompatibility AT moanchun antibacterialtitaniumplatedepositedbysilvernanoparticlesexhibitscellcompatibility AT zhiminzhu antibacterialtitaniumplatedepositedbysilvernanoparticlesexhibitscellcompatibility AT etal antibacterialtitaniumplatedepositedbysilvernanoparticlesexhibitscellcompatibility
_version_	1718398540055576576

Antibacterial titanium plate deposited by silver nanoparticles exhibits cell compatibility

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