Combination of preoperative tumour markers and lymphovascular invasion with TNM staging as a cost and labour efficient subtyping of colorectal cancer

Abstract Tumour-Node-Metastasis (TNM) staging of colorectal cancer (CRC) needs further classification for better treatment because of disease heterogeneity. Although molecular classifications which are expensive and laborious are under study, cost and labour efficient subtyping is desirable. We asse...

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Autores principales:	Tomoki Yamano, Shinichi Yamauchi, Masataka Igeta, Yuya Takenaka, Jihyung Song, Kei Kimura, Michiko Yasuhara, Akihito Babaya, Kozo Kataoka, Naohito Beppu, Masataka Ikeda, Naohiro Tomita, Kenichi Sugihara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/460b0b5e75cd4a79bae937b13b304d9d
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spelling	oai:doaj.org-article:460b0b5e75cd4a79bae937b13b304d9d2021-12-02T17:45:03ZCombination of preoperative tumour markers and lymphovascular invasion with TNM staging as a cost and labour efficient subtyping of colorectal cancer10.1038/s41598-020-66652-z2045-2322https://doaj.org/article/460b0b5e75cd4a79bae937b13b304d9d2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-66652-zhttps://doaj.org/toc/2045-2322Abstract Tumour-Node-Metastasis (TNM) staging of colorectal cancer (CRC) needs further classification for better treatment because of disease heterogeneity. Although molecular classifications which are expensive and laborious are under study, cost and labour efficient subtyping is desirable. We assessed the combinations of preoperative tumour marker (TM) elevation and tumour lymphovascular invasion (LVI) as a solution. We used the pooled data of 7151 colon cancer (CC) patients and 4620 rectal cancer (RC) patients who received curative surgery between 2004 and 2008 in Japan. The best-matched subtyping for predicting relapse-free survival (RFS) was statistically selected using the c-index and Akaike’s information criterion. This subtyping (TM-LVI), which consisted of three categories by TM elevation status and severity of LVI status, was an independent prognostic factor for RFS of CC (stage IIa, IIIb, and IIIc) and RC (stage I, IIa, IIb, IIIa, and IIIb) and also for disease specific survival of CC (stage IIa, IIb, IIIb, and IIIc) and RC (all stage except for IIc). Although TM-LVI classified CRC patients into low and high recurrence risk groups, the application of adjuvant therapy was not accordance with the TM-LVI status. TM-LVI may be a cost and labour efficient subtyping of colorectal cancer for better treatment strategy.Tomoki YamanoShinichi YamauchiMasataka IgetaYuya TakenakaJihyung SongKei KimuraMichiko YasuharaAkihito BabayaKozo KataokaNaohito BeppuMasataka IkedaNaohiro TomitaKenichi SugiharaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tomoki Yamano Shinichi Yamauchi Masataka Igeta Yuya Takenaka Jihyung Song Kei Kimura Michiko Yasuhara Akihito Babaya Kozo Kataoka Naohito Beppu Masataka Ikeda Naohiro Tomita Kenichi Sugihara Combination of preoperative tumour markers and lymphovascular invasion with TNM staging as a cost and labour efficient subtyping of colorectal cancer
description	Abstract Tumour-Node-Metastasis (TNM) staging of colorectal cancer (CRC) needs further classification for better treatment because of disease heterogeneity. Although molecular classifications which are expensive and laborious are under study, cost and labour efficient subtyping is desirable. We assessed the combinations of preoperative tumour marker (TM) elevation and tumour lymphovascular invasion (LVI) as a solution. We used the pooled data of 7151 colon cancer (CC) patients and 4620 rectal cancer (RC) patients who received curative surgery between 2004 and 2008 in Japan. The best-matched subtyping for predicting relapse-free survival (RFS) was statistically selected using the c-index and Akaike’s information criterion. This subtyping (TM-LVI), which consisted of three categories by TM elevation status and severity of LVI status, was an independent prognostic factor for RFS of CC (stage IIa, IIIb, and IIIc) and RC (stage I, IIa, IIb, IIIa, and IIIb) and also for disease specific survival of CC (stage IIa, IIb, IIIb, and IIIc) and RC (all stage except for IIc). Although TM-LVI classified CRC patients into low and high recurrence risk groups, the application of adjuvant therapy was not accordance with the TM-LVI status. TM-LVI may be a cost and labour efficient subtyping of colorectal cancer for better treatment strategy.
format	article
author	Tomoki Yamano Shinichi Yamauchi Masataka Igeta Yuya Takenaka Jihyung Song Kei Kimura Michiko Yasuhara Akihito Babaya Kozo Kataoka Naohito Beppu Masataka Ikeda Naohiro Tomita Kenichi Sugihara
author_facet	Tomoki Yamano Shinichi Yamauchi Masataka Igeta Yuya Takenaka Jihyung Song Kei Kimura Michiko Yasuhara Akihito Babaya Kozo Kataoka Naohito Beppu Masataka Ikeda Naohiro Tomita Kenichi Sugihara
author_sort	Tomoki Yamano
title	Combination of preoperative tumour markers and lymphovascular invasion with TNM staging as a cost and labour efficient subtyping of colorectal cancer
title_short	Combination of preoperative tumour markers and lymphovascular invasion with TNM staging as a cost and labour efficient subtyping of colorectal cancer
title_full	Combination of preoperative tumour markers and lymphovascular invasion with TNM staging as a cost and labour efficient subtyping of colorectal cancer
title_fullStr	Combination of preoperative tumour markers and lymphovascular invasion with TNM staging as a cost and labour efficient subtyping of colorectal cancer
title_full_unstemmed	Combination of preoperative tumour markers and lymphovascular invasion with TNM staging as a cost and labour efficient subtyping of colorectal cancer
title_sort	combination of preoperative tumour markers and lymphovascular invasion with tnm staging as a cost and labour efficient subtyping of colorectal cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/460b0b5e75cd4a79bae937b13b304d9d
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Combination of preoperative tumour markers and lymphovascular invasion with TNM staging as a cost and labour efficient subtyping of colorectal cancer

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