The Role of the Tumor Microenvironment and Treatment Strategies in Colorectal Cancer

Colorectal cancer (CRC) has the second highest mortality rate among all cancers worldwide. Surgery, chemotherapy, radiotherapy, molecular targeting and other treatment methods have significantly prolonged the survival of patients with CRC. Recently, the emergence of tumor immunotherapy represented b...

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Autores principales:	Yaping Chen, Xiao Zheng, Changping Wu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	immunotherapy immune microenvironment bevacizumab PD-1 colorectal cancer Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/460b6faf0ce948ea926fabcdc233ee9f
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id	oai:doaj.org-article:460b6faf0ce948ea926fabcdc233ee9f
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spelling	oai:doaj.org-article:460b6faf0ce948ea926fabcdc233ee9f2021-12-02T09:45:28ZThe Role of the Tumor Microenvironment and Treatment Strategies in Colorectal Cancer1664-322410.3389/fimmu.2021.792691https://doaj.org/article/460b6faf0ce948ea926fabcdc233ee9f2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.792691/fullhttps://doaj.org/toc/1664-3224Colorectal cancer (CRC) has the second highest mortality rate among all cancers worldwide. Surgery, chemotherapy, radiotherapy, molecular targeting and other treatment methods have significantly prolonged the survival of patients with CRC. Recently, the emergence of tumor immunotherapy represented by immune checkpoint inhibitors (ICIs) has brought new immunotherapy options for the treatment of advanced CRC. As the efficacy of ICIs is closely related to the tumor immune microenvironment (TME), it is necessary to clarify the relationship between the immune microenvironment of CRC and the efficacy of immunotherapy to ensure that the appropriate drugs are selected. We herein review the latest research progress in the immune microenvironment and strategies related to immunotherapy for CRC. We hope that this review helps in the selection of appropriate treatment strategies for CRC patients.Yaping ChenXiao ZhengChangping WuChangping WuFrontiers Media S.A.articleimmunotherapyimmune microenvironmentbevacizumabPD-1colorectal cancerImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	immunotherapy immune microenvironment bevacizumab PD-1 colorectal cancer Immunologic diseases. Allergy RC581-607
spellingShingle	immunotherapy immune microenvironment bevacizumab PD-1 colorectal cancer Immunologic diseases. Allergy RC581-607 Yaping Chen Xiao Zheng Changping Wu Changping Wu The Role of the Tumor Microenvironment and Treatment Strategies in Colorectal Cancer
description	Colorectal cancer (CRC) has the second highest mortality rate among all cancers worldwide. Surgery, chemotherapy, radiotherapy, molecular targeting and other treatment methods have significantly prolonged the survival of patients with CRC. Recently, the emergence of tumor immunotherapy represented by immune checkpoint inhibitors (ICIs) has brought new immunotherapy options for the treatment of advanced CRC. As the efficacy of ICIs is closely related to the tumor immune microenvironment (TME), it is necessary to clarify the relationship between the immune microenvironment of CRC and the efficacy of immunotherapy to ensure that the appropriate drugs are selected. We herein review the latest research progress in the immune microenvironment and strategies related to immunotherapy for CRC. We hope that this review helps in the selection of appropriate treatment strategies for CRC patients.
format	article
author	Yaping Chen Xiao Zheng Changping Wu Changping Wu
author_facet	Yaping Chen Xiao Zheng Changping Wu Changping Wu
author_sort	Yaping Chen
title	The Role of the Tumor Microenvironment and Treatment Strategies in Colorectal Cancer
title_short	The Role of the Tumor Microenvironment and Treatment Strategies in Colorectal Cancer
title_full	The Role of the Tumor Microenvironment and Treatment Strategies in Colorectal Cancer
title_fullStr	The Role of the Tumor Microenvironment and Treatment Strategies in Colorectal Cancer
title_full_unstemmed	The Role of the Tumor Microenvironment and Treatment Strategies in Colorectal Cancer
title_sort	role of the tumor microenvironment and treatment strategies in colorectal cancer
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/460b6faf0ce948ea926fabcdc233ee9f
work_keys_str_mv	AT yapingchen theroleofthetumormicroenvironmentandtreatmentstrategiesincolorectalcancer AT xiaozheng theroleofthetumormicroenvironmentandtreatmentstrategiesincolorectalcancer AT changpingwu theroleofthetumormicroenvironmentandtreatmentstrategiesincolorectalcancer AT changpingwu theroleofthetumormicroenvironmentandtreatmentstrategiesincolorectalcancer AT yapingchen roleofthetumormicroenvironmentandtreatmentstrategiesincolorectalcancer AT xiaozheng roleofthetumormicroenvironmentandtreatmentstrategiesincolorectalcancer AT changpingwu roleofthetumormicroenvironmentandtreatmentstrategiesincolorectalcancer AT changpingwu roleofthetumormicroenvironmentandtreatmentstrategiesincolorectalcancer
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The Role of the Tumor Microenvironment and Treatment Strategies in Colorectal Cancer

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